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View article: Lignin Conversion to Low-Molecular-Weight Aromatics via an Aerobic Oxidation-Hydrolysis Sequence: Comparison of Different Lignin Sources
Lignin Conversion to Low-Molecular-Weight Aromatics via an Aerobic Oxidation-Hydrolysis Sequence: Comparison of Different Lignin Sources Open
Diverse lignin samples have been subjected to a catalytic aerobic oxidation process, followed by formic-acid-induced hydrolytic depolymerization. The yield of monomeric aromatic compounds varies depending on the lignin plant source and pre…
View article: Multi-omic mitoprotease profiling defines a role for Oct1p in coenzyme Q production
Multi-omic mitoprotease profiling defines a role for Oct1p in coenzyme Q production Open
SUMMARY Mitoproteases are becoming recognized as key regulators of diverse mitochondrial functions, although their direct substrates are often difficult to discern. Through multi-omic profiling of diverse Saccharomyces cerevisiae mitoprote…
View article: Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity
Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity Open
The UbiB protein kinase-like (PKL) family is widespread, comprising one-quarter of microbial PKLs and five human homologs, yet its biochemical activities remain obscure. COQ8A (ADCK3) is a mammalian UbiB protein associated with ubiquinone …
View article: High-Resolution Filtering for Improved Small Molecule Identification via GC/MS
High-Resolution Filtering for Improved Small Molecule Identification via GC/MS Open
Gas chromatography/mass spectrometry (GC/MS) has long been considered one of the premiere analytical tools for small molecule analysis. Recently, a number of GC/MS systems equipped with high-resolution mass analyzers have been introduced. …
View article: Metabolism of Multiple Aromatic Compounds in Corn Stover Hydrolysate by <i>Rhodopseudomonas palustris</i>
Metabolism of Multiple Aromatic Compounds in Corn Stover Hydrolysate by <i>Rhodopseudomonas palustris</i> Open
Lignocellulosic biomass hydrolysates hold great potential as a feedstock for microbial biofuel production, due to their high concentration of fermentable sugars. Present at lower concentrations are a suite of aromatic compounds that can in…
View article: Plant-derived antifungal agent poacic acid targets β-1,3-glucan
Plant-derived antifungal agent poacic acid targets β-1,3-glucan Open
Significance The search for new antifungal compounds is struggling to keep pace with emerging fungicide resistance. Through chemoprospecting of an untapped reservoir of inhibitory compounds, lignocellulosic hydrolysates, we have identified…