Arolyn Conwill
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View article: High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV
High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV Open
Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutations. While many tools have been develop…
View article: Intraspecies dynamics underlie the apparent stability of two important skin microbiome species
Intraspecies dynamics underlie the apparent stability of two important skin microbiome species Open
Adult human facial skin microbiomes are remarkably similar at the species level, dominated by Cutibacterium acnes and Staphylococcus epidermidis, yet each person harbors a unique community of strains. Understanding how person-specific comm…
View article: Previously hidden intraspecies dynamics underlie the apparent stability of two important skin microbiome species
Previously hidden intraspecies dynamics underlie the apparent stability of two important skin microbiome species Open
Adult human facial skin microbiomes are remarkably similar at the species-level, dominated by Cutibacterium acnes and Staphylococcus epidermidis, yet each person harbors a unique community of strains. Understanding how person-specific comm…
View article: 254. Genomic diversity of Gram-negative Bacilli from Bloodstream Infections in Hospitalized Children
254. Genomic diversity of Gram-negative Bacilli from Bloodstream Infections in Hospitalized Children Open
Background Gram-negative bloodstream infection (BSI) in hospitalized children is associated with significant morbidity and mortality. It is unclear whether bacterial clonality of isolates during BSI in a unique patient is associated with c…
View article: 966. Large-Scale Evaluation of AST Prediction using Resistance Marker Presence/Absence vs. Machine Learning on WGS Data
966. Large-Scale Evaluation of AST Prediction using Resistance Marker Presence/Absence vs. Machine Learning on WGS Data Open
Background Whole genome sequencing (WGS) of bacterial pathogens directly from clinical samples or cultured isolates is a promising technique for diagnosing infections, yet challenges remain in using WGS to guide antimicrobial therapy. The …
View article: Anatomy promotes neutral coexistence of strains in the human skin microbiome
Anatomy promotes neutral coexistence of strains in the human skin microbiome Open
What enables strains of the same species to coexist in a microbiome? Here, we investigate if host anatomy can explain strain co-residence of Cutibacterium acnes , the most abundant species on human skin. We reconstruct on-person evolution …
View article: Rapid, inexpensive measurement of synthetic bacterial community composition by Sanger sequencing
Rapid, inexpensive measurement of synthetic bacterial community composition by Sanger sequencing Open
Simple synthetic bacterial communities are powerful tools for studying microbial ecology and evolution, as they enable rapid iteration between controlled laboratory experiments and theoretical modeling. However, their utility is hampered b…
View article: Migration alters oscillatory dynamics and promotes survival in connected bacterial populations
Migration alters oscillatory dynamics and promotes survival in connected bacterial populations Open
Migration influences population dynamics on networks, thereby playing a vital role in scenarios ranging from species extinction to epidemic propagation. While low migration rates prevent local populations from becoming extinct, high migrat…
View article: Oscillatory dynamics in a bacterial cross-protection mutualism
Oscillatory dynamics in a bacterial cross-protection mutualism Open
Significance Enzymatic deactivation of antibiotics is a cooperative behavior that can allow resistant cells to protect sensitive cells from antibiotics. The prevalence of this mechanism of antibiotic resistance in clinical isolates and in …