Aron Judd P. Mendiola
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View article: O-GlcNAcylation of nuclear proteins in the mouse liver exhibit daily oscillations that are influenced by meal timing
O-GlcNAcylation of nuclear proteins in the mouse liver exhibit daily oscillations that are influenced by meal timing Open
The liver circadian clock and hepatic transcriptome are highly responsive to metabolic signals generated from feeding–fasting rhythm. Previous studies have identified a number of nutrient-sensitive signaling pathways that could interpret m…
View article: Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment
Light and sex modify <i>Snord116</i> genotype effects on metabolism, behavior, and imprinted gene networks following circadian entrainment Open
Summary Mammals utilize imprinted and X-linked epigenetic mechanisms in development, metabolism, and behavior. Imprinted genes, including Prader-Willi syndrome Snord116 noncoding RNAs, are implicated in the regulation of sleep and circadia…
View article: Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons
Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons Open
Human cell line models, including the neuronal precursor line LUHMES, are important for investigating developmental transcriptional dynamics within imprinted regions, particularly the 15q11-q13 Angelman (AS) and Prader-Willi (PWS) syndrome…
View article: Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression
Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression Open
The liver circadian clock and hepatic transcriptome are highly responsive to metabolic signals generated from feeding-fasting rhythm. Previous studies have identified a number of nutrient-sensitive signaling pathways that could interpret m…
View article: Integration of CTCF Loops, Methylome, and Transcriptome in Differentiating LUHMES as a Model for Imprinting Dynamics of the 15q11-q13 Locus in Human Neurons
Integration of CTCF Loops, Methylome, and Transcriptome in Differentiating LUHMES as a Model for Imprinting Dynamics of the 15q11-q13 Locus in Human Neurons Open
Human cell line models, including the neuronal precursor line LUHMES, are important for investigating developmental transcriptional dynamics within imprinted regions, particularly the 15q11-q13 Angelman (AS) and Prader-Willi (PWS) syndrome…
View article: Epigenetics in Prader-Willi Syndrome
Epigenetics in Prader-Willi Syndrome Open
Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder that affects approximately 1 in 20,000 individuals worldwide. Symptom progression in PWS is classically characterized by two nutritional stages. Stage 1 is hypotonia charact…
View article: Phosphoserine inhibits neighboring arginine methylation in the RKS motif of histone H3
Phosphoserine inhibits neighboring arginine methylation in the RKS motif of histone H3 Open