Peter A. Suci
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View article: <i>Aggregatibacter actinomycetemcomitans</i>biofilm killing by a targeted ciprofloxacin prodrug
<i>Aggregatibacter actinomycetemcomitans</i>biofilm killing by a targeted ciprofloxacin prodrug Open
A pH-sensitive ciprofloxacin prodrug was synthesized and targeted against biofilms of the periodontal pathogen Aggregatibacter actinomycetemcomitans (Aa). The dose required to reduce the viability of a mature biofilm of Aa by ∼80% was in t…
View article: Targeted Delivery of a Photosensitizer to <i>Aggregatibacter actinomycetemcomitans</i> Biofilm
Targeted Delivery of a Photosensitizer to <i>Aggregatibacter actinomycetemcomitans</i> Biofilm Open
The ability to selectively target specific biofilm species with antimicrobials would enable control over biofilm consortium composition, with medical applications in treatment of infections on mucosal surfaces that are colonized by a mixtu…
View article: Particle Assembly and Ultrastructural Features Associated with Replication of the Lytic Archaeal Virus <i>Sulfolobus</i> Turreted Icosahedral Virus
Particle Assembly and Ultrastructural Features Associated with Replication of the Lytic Archaeal Virus <i>Sulfolobus</i> Turreted Icosahedral Virus Open
Little is known about the replication cycle of archaeal viruses. We have investigated the ultrastructural changes of Sulfolobus solfataricus P2 associated with infection by Sulfolobus t urreted i cosahedral v irus (STIV). A time course of …
View article: Synthesis of a Cross-Linked Branched Polymer Network in the Interior of a Protein Cage
Synthesis of a Cross-Linked Branched Polymer Network in the Interior of a Protein Cage Open
A goal of biomimetic chemistry is to use the hierarchical architecture inherent in biological systems to guide the synthesis of functional three-dimensional structures. Viruses and other highly symmetrical protein cage architectures provid…
View article: Correct charge state assignment of native electrospray spectra of protein complexes
Correct charge state assignment of native electrospray spectra of protein complexes Open
Correct charge state assignment is crucial to assigning an accurate mass to supramolecular complexes analyzed by electrospray mass spectrometry. Conventional charge state assignment techniques fall short of reliably and unambiguously predi…
View article: A Small Subpopulation of Blastospores in <i>Candida albicans</i> Biofilms Exhibit Resistance to Amphotericin B Associated with Differential Regulation of Ergosterol and <i>β</i> -1,6-Glucan Pathway Genes
A Small Subpopulation of Blastospores in <i>Candida albicans</i> Biofilms Exhibit Resistance to Amphotericin B Associated with Differential Regulation of Ergosterol and <i>β</i> -1,6-Glucan Pathway Genes Open
The resistance of Candida albicans biofilms to a broad spectrum of antimicrobial agents has been well documented. Biofilms are known to be heterogeneous, consisting of microenvironments that may induce formation of resistant subpopulations…
View article: Action of Chlorhexidine Digluconate against Yeast and Filamentous Forms in an Early-Stage<i>Candida albicans</i>Biofilm
Action of Chlorhexidine Digluconate against Yeast and Filamentous Forms in an Early-Stage<i>Candida albicans</i>Biofilm Open
An in situ method for sensitive detection of differences in the action of chlorhexidine against subpopulations of cells in Candida albicans biofilms is described. Detection relies on monitoring the kinetics of propidium iodide (PI) penetra…
View article: Combined light microscopy and attenuated total reflection fourier transform infrared spectroscopy for integration of biofilm structure, distribution, and chemistry at solid-liquid interfaces
Combined light microscopy and attenuated total reflection fourier transform infrared spectroscopy for integration of biofilm structure, distribution, and chemistry at solid-liquid interfaces Open
Reflected differential interference contrast microscopy and attenuated total reflection Fourier transform infrared spectroscopy were used to obtain complementary data on the structural and chemical properties of a biofilm. This information…
View article: Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics
Comparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics Open
Attenuated total reflection Fourier transform infrared spectroscopy was used to measure transport of the fluoroquinolones (FQs) ciprofloxacin and levofloxacin into Pseudomonas aeruginosa biofilms. Biofilms were exposed to each FQ at dose l…
View article: Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms
Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms Open
Bacterial infections associated with indwelling medical devices often demonstrate an intrinsic resistance to antimicrobial therapies. In order to explore the possibility of transport limitation to biofilm bacteria as a contributing factor,…