Ambreen Ilyas
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View article: Next-Generation Protein Sequencing: Nanopore and AI-Assisted Decoding of Posttranslational Modifications—A Narrative Review
Next-Generation Protein Sequencing: Nanopore and AI-Assisted Decoding of Posttranslational Modifications—A Narrative Review Open
BACKGROUND Proteins are versatile biomolecules whose functionality is intrinsically linked to their structural hierarchy—primary, secondary, and tertiary organization. Advances in structural genomics and integrative structural biology have…
View article: Decoding the Role of NF-κB Signaling in COVID-19 Severity and Inflammation
Decoding the Role of NF-κB Signaling in COVID-19 Severity and Inflammation Open
BACKGROUND Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with an overactive immune response, contributing to disease severity. The nuclear factor kappa-…
View article: Lipid-Protein Interplay: How the Plant Plasma Membrane H-ATPase Dynamically Interacts with Its Lipid Environment: A Review
Lipid-Protein Interplay: How the Plant Plasma Membrane H-ATPase Dynamically Interacts with Its Lipid Environment: A Review Open
The plasma membrane (PM) H+-ATPase is the primary electrogenic proton pump in plants, energising secondary transport systems by generating a proton motive force essential for nutrient uptake, cell expansion, and stress responses. This revi…
View article: Climate Variability, Biodiversity, and Human Dynamics in the Himalayas: A 2000-Year Historical and Predictive Study
Climate Variability, Biodiversity, and Human Dynamics in the Himalayas: A 2000-Year Historical and Predictive Study Open
BACKGROUND The Himalayan region, renowned for its unique biogeography and pivotal role in shaping South Asia’s climate, is one of the world’s most ecologically sensitive areas. Over the past 2000 years, it has experienced significant clima…
View article: Biocompatibility Assessment of Chitosan/Guar-Gum-Based Hydrogels Enriched with Ratan Jot Extract in a Murine Wound-Healing Model: Insights into Hepatotoxicity and Liver Health
Biocompatibility Assessment of Chitosan/Guar-Gum-Based Hydrogels Enriched with Ratan Jot Extract in a Murine Wound-Healing Model: Insights into Hepatotoxicity and Liver Health Open
Hydrogels are widely employed in wound care owing to their moisture-retentive, biocompatible, and tissue-repair properties. Incorporating natural plant extracts, such as Onosma echioides (commonly known as ratan jot), may enhance their the…
View article: Innovative Enzymatic and Microbial Approaches for Wastewater Bioremediation: Advances in Enzyme Engineering, Biotechnology, and Nanotechnology for Sustainable Water Management—A Comprehensive Review
Innovative Enzymatic and Microbial Approaches for Wastewater Bioremediation: Advances in Enzyme Engineering, Biotechnology, and Nanotechnology for Sustainable Water Management—A Comprehensive Review Open
The increasing global population and escalating levels of industrial and domestic effluents underscore the urgent need for innovative and sustainable wastewater-treatment technologies. Conventional wastewater-treatment methods—including ph…
View article: Exploring the Novel Potential of Newly Discovered Thermophile Metallosphaera Sedula: Insights into DNA Polymerase IV and Adenylyl Cyclase; Breakthroughs in Biotechnology and Industrial Innovation
Exploring the Novel Potential of Newly Discovered Thermophile Metallosphaera Sedula: Insights into DNA Polymerase IV and Adenylyl Cyclase; Breakthroughs in Biotechnology and Industrial Innovation Open
Background In this study, we conducted comprehensive genomic and proteomic analyses to elucidate the molecular mechanisms underlying the observed physiological responses, employing advanced sequencing and bioinformatics tools. Thermophilic…
View article: Exploring the Novel Potential of Newly Discovered Thermophile Metallosphaera sedula: Insights into DNA Polymerase IV and Adenylyl Cyclase; Breakthroughs in Biotechnology and Industrial Innovation
Exploring the Novel Potential of Newly Discovered Thermophile Metallosphaera sedula: Insights into DNA Polymerase IV and Adenylyl Cyclase; Breakthroughs in Biotechnology and Industrial Innovation Open
Background: In this study, we conducted comprehensive genomic and proteomic analyses to elucidate the molecular mechanisms underlying the observed physiological responses, employing advanced sequencing and bioinformatics tools. Thermophili…
View article: The Role of Vitamin B12 Deficiency in Alzheimer’s Disease: A Geographical Case-Control Study on Hematological Parameters
The Role of Vitamin B12 Deficiency in Alzheimer’s Disease: A Geographical Case-Control Study on Hematological Parameters Open
Background: Alzheimer’s disease (AD) is a common condition among the senior population. It has been proposed that certain dietary deficiencies, including low levels of vitamin B12, are causes for disease progression. Objectives: The purpos…
View article: CRISPR/Cas9-Mediated Modulation of mTOR Signaling: A Multi-Dimensional Approach for Muscle Disease Intervention, Metabolic Regulation, and Mechanical Stress
CRISPR/Cas9-Mediated Modulation of mTOR Signaling: A Multi-Dimensional Approach for Muscle Disease Intervention, Metabolic Regulation, and Mechanical Stress Open
Background: Myoblasts (satellite cells) possess the characteristics to distinguish between skeletal muscles and play crucial roles in the proliferation, differentiation, and growth of skeletal muscles. The mammalian target of rapamycin (mT…
View article: The Influence of Environmental Factors on Cardiovascular Disease Risk: A Comprehensive Review
The Influence of Environmental Factors on Cardiovascular Disease Risk: A Comprehensive Review Open
Cardiovascular disease is a leading risk factor globally and has been proven to be fatal, with nearly 18 million deaths worldwide each year, accounting for one-third of the morbidity and mortality from all other causes. Cardiovascular dise…
View article: Nutritional and therapeutic potential of nutmeg ( <i>Myristica fragrans</i> ): A concurrent review
Nutritional and therapeutic potential of nutmeg ( <i>Myristica fragrans</i> ): A concurrent review Open
The global health sector is changing with more consensus towards the consumption of natural products to improve the health of mankind. As a result, the nutrition market diversified with the inclusion of new herbal products with each passin…