Arryn Craney
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View article: P-1339. Navigating Antibiotic Susceptibility Testing: The Antibiotic Breakpoint Explorer (ABE 1.0)
P-1339. Navigating Antibiotic Susceptibility Testing: The Antibiotic Breakpoint Explorer (ABE 1.0) Open
Background The landscape of antibiotic susceptibility testing has evolved significantly, with constant revisions to antibiotic breakpoint definitions by key standard-setting bodies: the Clinical and Laboratory Standards Institute (CLSI), t…
View article: P-2142. Cross-Reactivity of Fungal Enzyme Immunoassays (EIA): Implications for Clinical Diagnosis in Patients with Autoimmune Disease
P-2142. Cross-Reactivity of Fungal Enzyme Immunoassays (EIA): Implications for Clinical Diagnosis in Patients with Autoimmune Disease Open
Background The immune system exhibits remarkable discriminatory power, distinguishing between self and non-self to mount protective responses against infections. In clinical diagnostics targeting dimorphic fungi, this immunological discrim…
View article: Analytical and clinical validation of direct detection of antimicrobial resistance markers by plasma microbial cell-free DNA sequencing
Analytical and clinical validation of direct detection of antimicrobial resistance markers by plasma microbial cell-free DNA sequencing Open
Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance as a valuable adjunct to standard-of-care testing for diagnosis of infections throughout the body. Here, we report the analytical and clinical validation…
View article: Analytical and Clinical Validation of Direct Detection of Antimicrobial Resistance Markers by Plasma Microbial Cell-free DNA Sequencing
Analytical and Clinical Validation of Direct Detection of Antimicrobial Resistance Markers by Plasma Microbial Cell-free DNA Sequencing Open
Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance as a valuable adjunct to standard-of-care testing for diagnosis of infections throughout the body. Here we report the analytical and clinical validation …
View article: Editorial: Women and clinical microbiology 2021
Editorial: Women and clinical microbiology 2021 Open
EDITORIAL article Front. Cell. Infect. Microbiol., 21 October 2022Sec. Clinical Microbiology Volume 12 - 2022 | https://doi.org/10.3389/fcimb.2022.999967
View article: Temporal Dynamics of Nasopharyngeal and Tracheal Severe Acute Respiratory Syndrome Coronavirus 2 Cycle Thresholds in Coronavirus Disease 2019 Patients With Tracheostomy
Temporal Dynamics of Nasopharyngeal and Tracheal Severe Acute Respiratory Syndrome Coronavirus 2 Cycle Thresholds in Coronavirus Disease 2019 Patients With Tracheostomy Open
In this study of 45 patients with COVID-19 undergoing tracheostomy, nasopharyngeal and tracheal cycle threshold (Ct) values were analyzed. Ct values rose to 37.9 by the time of tracheostomy and remained >35 postoperatively, demonstratin…
View article: System-wide transcriptome damage and tissue identity loss in COVID-19 patients
System-wide transcriptome damage and tissue identity loss in COVID-19 patients Open
The molecular mechanisms underlying the clinical manifestations of coronavirus disease 2019 (COVID-19), and what distinguishes them from common seasonal influenza virus and other lung injury states such as acute respiratory distress syndro…
View article: System-wide transcriptome damage and tissue identity loss in COVID-19 patients
System-wide transcriptome damage and tissue identity loss in COVID-19 patients Open
View article: Performance Evaluation of the MatMaCorp COVID-19 2SF Assay for the Detection of SARS-CoV-2 from Nasopharyngeal Swabs
Performance Evaluation of the MatMaCorp COVID-19 2SF Assay for the Detection of SARS-CoV-2 from Nasopharyngeal Swabs Open
The demand for molecular testing for COVID-19 remains to be met. This study of the MatMaCorp Solas 8 device and COVID-19 test provides the first evaluation of this platform.
View article: A Machine Learning Model Incorporating Laboratory Blood Tests Discriminates Between SARS-CoV-2 and Influenza Infections at Emergency Department Visit
A Machine Learning Model Incorporating Laboratory Blood Tests Discriminates Between SARS-CoV-2 and Influenza Infections at Emergency Department Visit Open
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza virus are contagious respiratory pathogens with similar symptoms but require different treatment and management strategies. This study investigated whe…
View article: Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States
Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States Open
View article: Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions Open
View article: Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps
Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps Open
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has infected over 115 million people and caused over 2.5 million deaths worldwide. Yet, the molecular mechanisms underlying the clinical manifestations of COVID-19, as …
View article: Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States
Early introductions and community transmission of SARS-CoV-2 variant B.1.1.7 in the United States Open
Summary The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because of its increased transmissibility. Over 2500 COVID-19 cases associated with this varian…
View article: Rapid Implementation of Severe Acute Respiratory Syndrome Coronavirus 2 Emergency Use Authorization RT-PCR Testing and Experience at an Academic Medical Institution
Rapid Implementation of Severe Acute Respiratory Syndrome Coronavirus 2 Emergency Use Authorization RT-PCR Testing and Experience at an Academic Medical Institution Open
View article: Clinical Performance of SARS-CoV-2 Molecular Tests
Clinical Performance of SARS-CoV-2 Molecular Tests Open
Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical performance of these tests is still poorly understood, particula…
View article: Rapid implementation of SARS-CoV-2 emergency use authorization RT-PCR testing and experience at an academic medical institution
Rapid implementation of SARS-CoV-2 emergency use authorization RT-PCR testing and experience at an academic medical institution Open
An epidemic caused by an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in December 2019 has since rapidly spread internationally, requiring urgent response from the clinical diagnostics community. We pre…
View article: Clinical Performance of SARS-CoV-2 Molecular Testing
Clinical Performance of SARS-CoV-2 Molecular Testing Open
Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the test clinical performance is poorly understood. From 3/10/2020-5/1/2020 N…
View article: Comparison of Two High-Throughput Reverse Transcription-PCR Systems for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2
Comparison of Two High-Throughput Reverse Transcription-PCR Systems for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the cause of a worldwide pandemic. Many commercial SARS-CoV-2 reverse transcription-PCR (RT-PCR) assays have received Emergency Use Authorization from the U.S. Foo…
View article: Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions
Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions Open
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused thousands of deaths worldwide, including >18,000 in New York City (NYC) alone. The sudden emergence of this pandemic has highlighted a pressing clinical need for r…
View article: Inhibition of Protein Secretion in <i>Escherichia coli</i> and Sub-MIC Effects of Arylomycin Antibiotics
Inhibition of Protein Secretion in <i>Escherichia coli</i> and Sub-MIC Effects of Arylomycin Antibiotics Open
At sufficient concentrations, antibiotics effectively eradicate many bacterial infections. However, during therapy, bacteria are unavoidably exposed to lower antibiotic concentrations, and sub-MIC exposure can result in a wide variety of o…
View article: 2290. Identification of Pathogens in Synovial Fluid Samples With an Automated Multiplexed Molecular Detection System
2290. Identification of Pathogens in Synovial Fluid Samples With an Automated Multiplexed Molecular Detection System Open
BACKGROUND: Bone and Joint Infections (BJI) have high morbidity and are difficult to treat infections. Culture-based diagnosis is limited in its ability to recover fastidious bacteria and because several organisms can be involved; culture …
View article: <i>Notes from the Field:</i> Toxigenic <i>Vibrio cholerae</i> O141 in a Traveler to Florida — Nebraska, 2017
<i>Notes from the Field:</i> Toxigenic <i>Vibrio cholerae</i> O141 in a Traveler to Florida — Nebraska, 2017 Open
View article: Stable Signal Peptides and the Response to Secretion Stress in <i>Staphylococcus aureus</i>
Stable Signal Peptides and the Response to Secretion Stress in <i>Staphylococcus aureus</i> Open
Protein secretion is essential, but how it is managed is poorly understood. In bacteria, most secreted proteins require release from the outer surface of the cytoplasmic membrane by type I signal peptidase (SPase), which cleaves the mature…
View article: Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence
Not just an antibiotic target: Exploring the role of type I signal peptidase in bacterial virulence Open
View article: An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus
An Alternative Terminal Step of the General Secretory Pathway in Staphylococcus aureus Open
Type I signal peptidase (SPase) is essential for viability in wild-type bacteria because the terminal step of the bacterial general secretory pathway requires its proteolytic activity to release proteins from their membrane-bound N-termina…
View article: A Putative Cro-Like Repressor Contributes to Arylomycin Resistance in Staphylococcus aureus
A Putative Cro-Like Repressor Contributes to Arylomycin Resistance in Staphylococcus aureus Open
Antibiotic-resistant bacteria are a significant public health concern and motivate efforts to develop new classes of antibiotics. One such class of antibiotics is the arylomycins, which target type I signal peptidase (SPase), the enzyme re…