Arshad Rizvi
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View article: Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains
Secondary Metabolites from a New Antibiotic-Producing Endophytic Streptomyces Isolate Inhibited Pathogenic and Multidrug-Resistant Mycobacterium tuberculosis Strains Open
The long regimen of drug therapy, the emergence of drug-resistance (DR), and infections with non-tuberculous mycobacteria (NTMs) are alarming challenges in controlling tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (M.tb…
View article: KipOTIA detoxifies 5-oxoproline and promotes the growth of<i>Clostridioides difficile</i>
KipOTIA detoxifies 5-oxoproline and promotes the growth of<i>Clostridioides difficile</i> Open
Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore fo…
View article: Glycine fermentation by <i>C. difficile</i> promotes virulence and spore formation, and is induced by host cathelicidin
Glycine fermentation by <i>C. difficile</i> promotes virulence and spore formation, and is induced by host cathelicidin Open
Clostridioides difficile is a leading cause of antibiotic-associated diarrheal disease. C. difficile colonization, growth, and toxin production in the intestine is strongly associated with its ability to use amino acids to generate energy,…
View article: The predicted acetoin dehydrogenase pathway represses sporulation of<i>Clostridioides difficile</i>
The predicted acetoin dehydrogenase pathway represses sporulation of<i>Clostridioides difficile</i> Open
Clostridioides difficile is a major gastrointestinal pathogen that is transmitted as a dormant spore. As an intestinal pathogen, C. difficile must contend with variable environmental conditions, including fluctuations in pH and nutrient av…
View article: Glycine fermentation by<i>C. difficile</i>promotes virulence, spore formation, and is induced by host cathelicidin
Glycine fermentation by<i>C. difficile</i>promotes virulence, spore formation, and is induced by host cathelicidin Open
SUMMARY The amino acid glycine is enriched in the dysbiotic gut and is suspected to contribute to Clostridioides difficile infection. We hypothesized that the use of glycine as an energy source contributes to colonization of the intestine …
View article: Host manipulation by bacterial type <scp>III</scp> and type <scp>IV</scp> secretion system effector proteases
Host manipulation by bacterial type <span>III</span> and type <span>IV</span> secretion system effector proteases Open
Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to irreversible fragmentation or degradation of their substrates. Therefore they control many critical cell fate decisions in eukaryotes. Bacterial pathog…
View article: Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers
Active and prospective latent tuberculosis are associated with different metabolomic profiles: clinical potential for the identification of rapid and non-invasive biomarkers Open
Although 23% of world population is infected with Mycobacterium tuberculosis (M. tb), only 5-10% manifest the disease. Individuals surely exposed to M. tb that remain asymptomatic are considered potential latent TB (LTB) cases. Such asympt…
View article: Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses
Rewiring of Metabolic Network in Mycobacterium tuberculosis During Adaptation to Different Stresses Open
Metabolic adaptation of Mycobacterium tuberculosis (M. tuberculosis) to microbicidal intracellular environment of host macrophages is fundamental to its pathogenicity. However, an in-depth understanding of metabolic adjustments through key…
View article: Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis
Metabolomics Studies To Decipher Stress Responses in Mycobacterium smegmatis Point to a Putative Pathway of Methylated Amine Biosynthesis Open
Alterations in metabolite levels provide fast and direct means to regulate enzymatic reactions and, therefore, metabolic pathways. This study documents, for the first time, the metabolic changes that occur in Mycobacterium smegmatis as a r…
View article: Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of <i>Mycobacterium tuberculosis</i>
Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of <i>Mycobacterium tuberculosis</i> Open
The transcription factor Rv0081 of Mycobacterium tuberculosis controls hypoxic gene expression and acts as a regulatory hub in the latent phase of tuberculosis (TB) infection. We report here the crystal structure of Rv0081 at 2.9 Å resolut…
View article: Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of<i>Mycobacterium tuberculosis</i>
Structural basis of hypoxic gene regulation by the Rv0081 transcription factor of<i>Mycobacterium tuberculosis</i> Open
The transcription factor Rv0081 of M. tuberculosis controls the hypoxic gene expression and acts as a regulatory hub in the latent phase of tuberculosis infection. We report here the crystal structure of Rv0081 at 3.3 Å resolution revealin…
View article: Understanding HIV-Mycobacteria synergism through comparative proteomics of intra-phagosomal mycobacteria during mono- and HIV co-infection
Understanding HIV-Mycobacteria synergism through comparative proteomics of intra-phagosomal mycobacteria during mono- and HIV co-infection Open
Mycobacterium tuberculosis ( Mtb ) is the most common co-infection in HIV patients and a serious co-epidemic. Apart from increasing the risk of reactivation of latent tuberculosis (TB), HIV infection also permits opportunistic infection of…
View article: Proteomics approach to understand reduced clearance of mycobacteria and high viral titers during HIV–mycobacteria co‐infection
Proteomics approach to understand reduced clearance of mycobacteria and high viral titers during HIV–mycobacteria co‐infection Open
Environmental mycobacteria, highly prevalent in natural and artificial (including chlorinated municipal water) niches, are emerging as new threat to human health, especially to HIV-infected population. These seemingly harmless non-pathogen…