Artem Chayka
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View article: Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea
Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea Open
The COVID‐19 pandemic, caused by the highly transmissible SARS‐CoV‐2 virus, has highlighted the urgent need for effective small‐molecule antivirals. To date, only a few such agents, including molnupiravir and remdesivir, have been approved…
View article: Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea
Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Based on <i>N</i> , <i>N′</i> ‐Diphenylurea Open
The COVID‐19 pandemic, caused by the highly transmissible SARS‐CoV‐2 virus, has highlighted the urgent need for effective small‐molecule antivirals. To date, only a few such agents, including molnupiravir and remdesivir, have been approved…
View article: Developing Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase
Developing Allosteric Inhibitors of SARS‐CoV‐2 RNA‐Dependent RNA Polymerase Open
The use of Fpocket and virtual screening techniques enabled us to identify potential allosteric druggable pockets within the SARS‐CoV‐2 RNA‐dependent RNA polymerase (RdRp). Of the compounds screened, compound 1 was identified as a promisin…
View article: Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine
Structure-Based Drug Design of ADRA2A Antagonists Derived from Yohimbine Open
Yohimbine, a natural indole alkaloid and a nonselective adrenoceptor antagonist, possesses potential benefits in treating inflammatory disorders and sepsis. Nevertheless, its broader clinical use faces challenges due to its low receptor se…