Arthur Goron
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View article: Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis
Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis Open
Background Animal studies and clinical data support the interest of citrulline as a promising therapeutic for sarcopenia. Citrulline is known to stimulate muscle protein synthesis, but how it affects energy metabolism to support the highly…
View article: Propriétés nutritionnelles de la citrulline : un nouvel acteur dans la régulation du métabolisme protéino-énergétique
Propriétés nutritionnelles de la citrulline : un nouvel acteur dans la régulation du métabolisme protéino-énergétique Open
Besides his role in the metabolism of the urea cycle, citrulline has many properties including the ability to stimulate muscle protein synthesis. However, protein synthesis is an important item of cell energy expenditure. Our work has expl…
View article: Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies
Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies Open
Citrulline (CIT) is an endogenous amino acid produced by the intestine. Recent literature has consistently shown CIT to be an activator of muscle protein synthesis (MPS). However, the underlying mechanism is still unknown. Our working hypo…