Arthur Kmit
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View article: Identification of novel F508del-CFTR traffic correctors among triazole derivatives
Identification of novel F508del-CFTR traffic correctors among triazole derivatives Open
The most prevalent cystic fibrosis (CF)-causing mutation - F508del - impairs the folding of CFTR protein, resulting in its defective trafficking and premature degradation. Small molecules termed correctors may rescue F508del-CFTR and there…
View article: Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target
Cross-talk of inflammatory mediators and airway epithelium reveals the cystic fibrosis transmembrane conductance regulator as a major target Open
Airway inflammation, mucus hyperproduction and epithelial remodelling are hallmarks of many chronic airway diseases, including asthma, COPD and cystic fibrosis. While several cytokines are dysregulated in these diseases, most studies focus…
View article: TMEM16A chloride channel does not drive mucus production
TMEM16A chloride channel does not drive mucus production Open
Airway mucus obstruction is the main cause of morbidity in cystic fibrosis, a disease caused by mutations in the CFTR Cl − channel. Activation of non-CFTR Cl − channels such as TMEM16A can likely compensate for defective CFTR. However, TME…
View article: Avaliação dos fármacos VX-809 E VX-770 na função da CFTR e a função de canais alternativos de cloreto em células primárias epiteliais das vias aéreas de pacientes com fibrose cística
Avaliação dos fármacos VX-809 E VX-770 na função da CFTR e a função de canais alternativos de cloreto em células primárias epiteliais das vias aéreas de pacientes com fibrose cística Open
View article: Extent of Rescue of F508del-CFTR Function by VX-809 and VX-770 in Human Nasal Epithelial Cells Correlates with SNP rs7512462 in SLC26A9 Gene in F508del/F508del Cystic Fibrosis Patients
Extent of Rescue of F508del-CFTR Function by VX-809 and VX-770 in Human Nasal Epithelial Cells Correlates with SNP rs7512462 in SLC26A9 Gene in F508del/F508del Cystic Fibrosis Patients Open
View article: WS18.4 SNP (rs7512462) in SLC26A9 chloride channel enhances CFTR function in human nasal epithelial cells from F508del/F508del patients
WS18.4 SNP (rs7512462) in SLC26A9 chloride channel enhances CFTR function in human nasal epithelial cells from F508del/F508del patients Open
View article: Associação dos parâmetros de crescimento e nutricionais com função pulmonar na fibrose cística: revisão da literatura
Associação dos parâmetros de crescimento e nutricionais com função pulmonar na fibrose cística: revisão da literatura Open
Made available in DSpace on 2017-08-17T19:17:47Z (GMT). No. of bitstreams: 1\n2-s2.0-84966478620.pdf: 616851 bytes, checksum: 0f4411c233428cbb422dc7f136b62ca0 (MD5)\n Previous issue date: 2016
View article: Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review
Association of growth and nutritional parameters with pulmonary function in cystic fibrosis: a literature review Open
View article: Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages Open
Purinergic P2X7 receptors (P2X7R) are fundamental to innate immune response. In macrophages, transient stimulation of P2X7R activates several transport mechanisms and induces the scrambling of phospholipids with subsequent membrane blebbin…
View article: Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity
Pharmacological evaluation of hybrid thiazolidin-4-one-1,3,5-triazines for NF-κB, biofilm and CFTR activity Open
A series of hybrid thiazolidin-4-one-1,3,5-triazines was evaluated for NF-κB, biofilm and CFTR activity.