Arthur Paquis
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View article: Gut microbiome signatures in iNPH: Insights from a shotgun metagenomics study
Gut microbiome signatures in iNPH: Insights from a shotgun metagenomics study Open
Idiopathic normal pressure hydrocephalus (iNPH), a leading cause of reversible dementia in older adults, is marked by ventriculomegaly, gait disturbances, cognitive decline, and urinary incontinence. Emerging evidence suggests that gut dys…
View article: Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model
Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model Open
Background The mechanisms underlying the protective effect of the e2 variant of the APOE gene (APOEe2) against Alzheimer’s disease (AD) have not been elucidated. We altered the microbiota of 3xTgAD mice by fecal microbiota transplantation …
View article: Fecal Microbiota Transplantation (<scp>FMT</scp>) From a Human at Low Risk for Alzheimer's Disease Improves Short‐Term Recognition Memory and Increases Neuroinflammation in a <scp>3xTg AD</scp> Mouse Model
Fecal Microbiota Transplantation (<span>FMT</span>) From a Human at Low Risk for Alzheimer's Disease Improves Short‐Term Recognition Memory and Increases Neuroinflammation in a <span>3xTg AD</span> Mouse Model Open
Human microbiota‐associated murine models, using fecal microbiota transplantation (FMT) from human donors, help explore the microbiome's role in diseases like Alzheimer's disease (AD). This study examines how gut bacteria from donors with …
View article: Stool bacteria from a human donor with Apolipoprotein E2-variant protect against Alzheimer's disease pathology in transgenic Alzheimer's disease mouse model
Stool bacteria from a human donor with Apolipoprotein E2-variant protect against Alzheimer's disease pathology in transgenic Alzheimer's disease mouse model Open
View article: Association of AD risk factors with plasma GFAP levels in a memory clinic population
Association of AD risk factors with plasma GFAP levels in a memory clinic population Open
Background Plasma glial fibrillary acidic protein (GFAP) is an emerging AD biomarker. We aimed to study how plasma GFAP correlated with age, clinical stage, sex, and the APOE4 status and whether amyloid pathology may mediate these associat…