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View article: Efflux and uptake of androgen sulfates using transporter-overexpressing HEK293 cells and membrane vesicles
Efflux and uptake of androgen sulfates using transporter-overexpressing HEK293 cells and membrane vesicles Open
Hydrophilic steroid conjugates require active and facilitated transport mechanisms for their distribution into tissues and excretion from the body. The ATP-binding cassette (ABC) and solute carrier organic anion (SLCO) transporters involve…
View article: Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides
Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides Open
Raloxifene has low bioavailability due to extensive glucuronidation in the intestine and the liver, and its pharmacokinetics is associated with high intra‐ and interindividual variability. Some of this variability could be explained by the…
View article: A personalized anti-cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella
A personalized anti-cancer vaccine for melanoma based on an approved vaccine against measles, mumps, and rubella Open
Common vaccines for infectious diseases have been repurposed as cancer immunotherapies. Intratumoural administration of these repurposed vaccines can induce immune cell infiltration into the treated tumour. Here, we have used an approved t…