Arturo Álvarez-Arenas
YOU?
Author Swipe
View article: A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma
A Simple 3D Cell Culture Method for Studying the Interactions between Human Mesenchymal Stromal/Stem Cells and Patients Derived Glioblastoma Open
We have developed a 3D biosphere model using patient-derived cells (PDCs) from glioblastoma (GBM), the major form of primary brain tumors in adult, plus cancer-activated fibroblasts (CAFs), obtained by culturing mesenchymal stem cells with…
View article: Practical identifiability analysis of a mechanistic model for the time to distant metastatic relapse and its application to renal cell carcinoma
Practical identifiability analysis of a mechanistic model for the time to distant metastatic relapse and its application to renal cell carcinoma Open
Distant metastasis-free survival (DMFS) curves are widely used in oncology. They are classically analyzed using the Kaplan-Meier estimator or agnostic statistical models from survival analysis. Here we report on a method to extract more in…
View article: Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression Open
Background Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological processes occurrin…
View article: Additional file 11 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Additional file 11 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression Open
Additional file 11: Supplementary Table S1.
View article: Additional file 13 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Additional file 13 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression Open
Additional file 13: Supplementary Table S3.
View article: Additional file 12 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression
Additional file 12 of Experimental and computational modeling for signature and biomarker discovery of renal cell carcinoma progression Open
Additional file 12: Supplementary Table S2.
View article: Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma Open
View article: Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models
Radiation protraction schedules for low-grade gliomas: a comparison between different mathematical models Open
We optimize radiotherapy (RT) administration strategies for treating low-grade gliomas. Specifically, we consider different tumour growth laws, both with and without spatial effects. In each scenario, we find the optimal treatment in the s…
View article: Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer
Interplay of Darwinian Selection, Lamarckian Induction and Microvesicle Transfer on Drug Resistance in Cancer Open
View article: Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy
Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy Open
In this paper, a non-trivial generalization of a mathematical model put forward in [35] to account for the development of resistance by tumors to chemotherapy is presented. A study of the existence and local stability of the solutions, as …
View article: Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem
Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem Open
Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing…
View article: Nonlinear waves in a simple model of high-grade glioma
Nonlinear waves in a simple model of high-grade glioma Open
We present an analysis of a mathematical model describing the key features of the most frequent and aggressive type of primary brain tumor: glioblastoma. The model captures the salient physiopathological characteristics of this type of tum…