Explanipedia

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors Open

Divyanshu Tiwari, K. Sawada, Annu Dalal, Sudha Mishra, Xaria X. Li , et al. · 2025

The conceptual framework of biased signaling has revolutionized our understanding of GPCR signaling and regulatory paradigms, and greatly impacted the efforts focused on the discovery of GPCR-targeted therapeutics. However, the mechanistic…

Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor Open

Nilanjana Banerjee, Manisankar Ganguly, A. Reyaz, Sudha Mishra, Annu Dalal , et al. · 2025

CXCR7, also known as atypical chemokine receptor 3 (ACKR3), is a naturally-biased, β-arrestin-coupled seven transmembrane receptor (7TMR) that lacks productive coupling with heterotrimeric G-proteins. Despite a critical involvement in canc…

Complement peptide receptors in GtoPdb v.2025.3 Open

Antonia Cianciulli, Arun K. Shukla, Maria Antonietta Panaro, Peter N. Monk, Vincenzo Mitolo , et al. · 2025

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [116]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a and C5a, generated upon stimulation of …

A conserved molecular mechanism orchestrates diverse ligand recognition at the complement anaphylatoxin receptor C3aR Open

Sudha Mishra, Annu Dalal, Manish K. Yadav, Ravi Yadav, Manisankar Ganguly , et al. · 2025

Molecular basis of naturally-encoded signaling-bias at the complement anaphylatoxin receptor, C5aR1 Open

Annu Dalal, Sudha Mishra, Manish K. Yadav, Ravi Yadav, Tomasz Maciej Stępniewski , et al. · 2025

Molecular fingerprints of a convergent mechanism orchestrating diverse ligand recognition and species-specific pharmacology at the complement anaphylatoxin receptors Open

Sudha Mishra, Manish K. Yadav, Annu Dalal, Manisankar Ganguly, Ravi Yadav , et al. · 2025

Complement anaphylatoxin receptors (C3aR and C5aR1) are prototypical G protein-coupled receptors (GPCRs) playing crucial physiological roles in innate immunity by combating pathogenic infections and orchestrating inflammatory responses. Th…

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system Open

Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Annu Dalal , et al. · 2025

Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2 Open

Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Sudha Mishra , et al. · 2025

Analyzing the Contribution of Moringa oleifera (Lam.) to the CO\(_2\) Stock and Other Advantages for Urban Residents Open

K. K. Chandra, Rajesh Kumar, Bhavana Dixit, Pusala Praveen Nayak, Atul Kumar Bhardwaj , et al. · 2024

Moringa oleifera Lam. is a tree with high nutritive values with essential nutrients, minerals, and vitamins. It makes the tree best for the urban residents in South Asian countries. The Moringa trees in Bilaspur city of Chhattisgarh, India…

Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor Open

Shirsha Saha, Basavraj Khanppnavar, Jagannath Maharana, H.R. Kim, Carlo Marion C. Carino , et al. · 2024

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution Open

Manish K. Yadav, Parishmita Sarma, Jagannath Maharana, Manisankar Ganguly, Sudha Mishra , et al. · 2024

A genetically-encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors Open

Parishmita Sarma, Vendula Marková, Nashrah Zaidi, Annu Dalal, Sudha Mishra , et al. · 2024

Agonist-induced interaction of G protein-coupled receptors (GPCRs) with β-arrestins (βarrs) is a critical mechanism that regulates the spatio-temporal pattern of receptor localization and downstream signaling. While the underlying mechanis…

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors Open

Shirsha Saha, Fumiya K. Sano, Saloni Sharma, Manisankar Ganguly, Sayantan Saha , et al. · 2024

Selectivity of natural agonists for their cognate receptors is one of the hallmarks of the members of GPCR family, and it is crucial for the specificity of downstream signal-transduction. However, this selectivity often breaks down in the …

Cryo-EM research in India Open

Arun K. Shukla, Manidipa Banerjee, Appu K. Singh, Aravind Penmatsa, Somnath Dutta , et al. · 2024

Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors Open

Jagannath Maharana, Fumiya K. Sano, Parishmita Sarma, Manish K. Yadav, Longhan Duan , et al. · 2024

β-arrestins (βarrs) are multifunctional proteins involved in signaling and regulation of seven transmembrane receptors (7TMRs), and their interaction is driven primarily by agonist-induced receptor activation and phosphorylation. Here, we …

The expanding footprint of basic biology research in India Open

Arun K. Shukla · 2024

Basic biology research in India has expanded in recent years, and addressing key challenges should enable this momentum to continue.

Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors Open

Manish K. Yadav, Jagannath Maharana, Ravi Yadav, Shirsha Saha, Parishmita Sarma , et al. · 2023

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system Open

Parishmita Sarma, Carlo Marion C. Carino, Deeksha Seetharama, Shubhi Pandey, Hemlata Dwivedi‐Agnihotri , et al. · 2023

Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms. Ligand promiscuity among these receptors makes them an interesti…

Structure of the human Duffy antigen receptor Open

Shirsha Saha, Basavraj Khanppnavar, Jagannath Maharana, H.R. Kim, Carlo Marion C. Carino , et al. · 2023

The Duffy antigen receptor, also known as FY glycoprotein or CD234, is a seven transmembrane protein expressed primarily at the surface of red blood cells, which displays promiscuous binding to multiple chemokines. Not only does it serve a…

Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors Open

Jagannath Maharana, Fumiya K. Sano, Parishmita Sarma, Manish K. Yadav, Longhan Duan , et al. · 2023

β-arrestins are multifunctional proteins that are critically involved in regulating spatio-temporal aspects of GPCR signaling. The interaction of β-arrestins with GPCRs is typically conceptualized in terms of receptor activation and phosph…

Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution Open

Manish K. Yadav, Parishmita Sarma, Manisankar Ganguly, Sudha Mishra, Jagannath Maharana , et al. · 2023

The Hydroxycarboxylic acid receptor 2 (HCA2), also known as the niacin receptor or GPR109A, is a prototypical G protein-coupled receptor that plays a central role in the inhibition of lipolytic and atherogenic activities in our body. Inter…

Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation Open

Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Kumar Singh , et al. · 2023

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation Open

Jak Grimes, Zsombor Kőszegi, Yann Lanoiselée, Tamara Miljuš, Shannon O’Brien , et al. · 2023

Structural insights into agonist-binding and activation of the human complement C3a receptor Open

Manish K. Yadav, Ravi Yadav, Parishmita Sarma, Jagannath Maharana, Chahat Soni , et al. · 2023

The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body’s innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of mul…

Structural insights into ligand-recognition, activation, and signaling-bias at the complement C5a receptor, C5aR1 Open

Shirsha Saha, Jagannath Maharana, Manish K. Yadav, Parishmita Sarma, Vinay Kumar Singh , et al. · 2023

Activation of the complement cascade is a critical part of our innate immune response against invading pathogens, and it operates in a concerted fashion with the antibodies and phagocytic cells towards the clearance of pathogens. The compl…

Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system Open

Arun K. Shukla · 2023

Supporting data

Single-molecule analysis of receptor-β-arrestin interactions in living cells Open

Jak Grimes, Zsombor Kőszegi, Yann Lanoiselée, Tamara Miljuš, Shannon O’Brien , et al. · 2022

SUMMARY β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and desensitization. Despite recent structural advances, the mechanisms that govern receptor–β-arrestin interactions at the plasma membrane of living cells …

A key GPCR phosphorylation motif discovered in arrestin2•CCR5 phosphopeptide complexes Open

Polina Isaikina, Ivana Petrović, Roman P. Jakob, Parishmita Sarma, Ashutosh Ranjan , et al. · 2022

Summary The two non-visual arrestin isoforms, arrestin2 and arrestin3 recognize and bind hundreds of G protein-coupled receptors (GPCRs) with different phosphorylation patterns leading to distinct functional outcomes. The impact of phospho…

Structural snapshots uncover a lock-and-key type conserved activation mechanism of β-arrestins by GPCRs Open

Jagannath Maharana, Parishmita Sarma, Manish K. Yadav, Sayantan Saha, Vinay Kumar Singh , et al. · 2022

Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a key determinant for the binding and activation of multifunctional regulatory proteins known as β-arrestins (βarrs). Although the primary sequence and phosphorylati…

Resonating with the signaling bias of CXCR7 Open

Parishmita Sarma, Arun K. Shukla · 2022

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