Arun Sett
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View article: Diaphragm Position on Chest Radiograph to Estimate Lung Volume in Neonates
Diaphragm Position on Chest Radiograph to Estimate Lung Volume in Neonates Open
Importance Using chest radiographs to guide lung aeration during respiratory support in infants is common practice and recommended in neonatal intensive care unit (NICU) guidelines, but this practice has never been validated. Objective To …
View article: Are we ready for volume targeting during high-frequency oscillatory ventilation in neonates?
Are we ready for volume targeting during high-frequency oscillatory ventilation in neonates? Open
View article: Speed of lung inflation at birth influences the initiation of lung injury in preterm lambs
Speed of lung inflation at birth influences the initiation of lung injury in preterm lambs Open
Gas flow is fundamental for driving tidal ventilation and, thus, the speed of lung motion, but current bias flow settings to support the preterm lung after birth do not have an evidence base. We aimed to determine the role of gas bias flow…
View article: Mechanical power made simple: validating a simplified calculation of mechanical power in preterm lungs
Mechanical power made simple: validating a simplified calculation of mechanical power in preterm lungs Open
Background The incidence of chronic lung disease is increasing, suggesting a need to explore novel ways to understand ventilator induced lung injury (VILI) in preterm infants. Mechanical power (MP) is a unifying measure of energy transferr…
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Author Index Open
View article: Surfactant as a drug carrier
Surfactant as a drug carrier Open
Drug delivery using a surfactant vehicle has the potential to prevent systemic side effects by delivering therapeutic agents directly to the respiratory system. The inherent chemical properties of surfactant allows it to readily distribute…
View article: Factors that determine first intubation attempt success in high-risk neonates
Factors that determine first intubation attempt success in high-risk neonates Open
Background Approximately 50% of all neonatal endotracheal intubation attempts are unsuccessful and associated with airway injury and cardiorespiratory instability. The aim of this study was to describe intubation practice at a high-risk Ne…
View article: Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby
Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby Open
We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including b…
View article: Lung ultrasound detects regional aeration inhomogeneity in ventilated preterm lambs
Lung ultrasound detects regional aeration inhomogeneity in ventilated preterm lambs Open
Background Inhomogeneous lung aeration is a significant contributor to preterm lung injury. EIT detects inhomogeneous aeration in the research setting. Whether LUS detects inhomogeneous aeration is unknown. The aim was to determine whether…
View article: Functional lung morphometry: another piece in the BPD prediction puzzle?
Functional lung morphometry: another piece in the BPD prediction puzzle? Open
View article: Quantitative lung ultrasound detects dynamic changes in lung recruitment in the preterm lamb
Quantitative lung ultrasound detects dynamic changes in lung recruitment in the preterm lamb Open
Background Lung ultrasound (LUS) may not detect small, dynamic changes in lung volume. Mean greyscale measurement using computer-assisted image analysis (Q-LUS MGV ) may improve the precision of these measurements. Methods Preterm lambs ( …
View article: Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb
Lung ultrasound of the dependent lung detects real-time changes in lung volume in the preterm lamb Open
Background Effective lung protective ventilation requires reliable, real-time estimation of lung volume at the bedside. Neonatal clinicians lack a readily available imaging tool for this purpose. Objective To determine the ability of lung …
View article: Lung Ultrasound in Early Preterm Life: A Window into the Future?
Lung Ultrasound in Early Preterm Life: A Window into the Future? Open