Arun Upadhyay
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View article: Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models
Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer’s disease models Open
In Alzheimer’s disease (AD), amyloid-beta (Aβ) peptides are produced by proteolytic cleavage of the amyloid precursor protein (APP), which can occur during synaptic vesicle (SV) cycling at presynapses. Precisely how amyloidogenic APP proce…
View article: Role of T Lymphocytes in Glioma Immune Microenvironment: Two Sides of a Coin
Role of T Lymphocytes in Glioma Immune Microenvironment: Two Sides of a Coin Open
Glioma is known for its immunosuppressive microenvironment, which makes it challenging to target through immunotherapies. Immune cells like macrophages, microglia, myeloid-derived suppressor cells, and T lymphocytes are known to infiltrate…
View article: Vesicular Transport and Amyloids: The Growing Relationship
Vesicular Transport and Amyloids: The Growing Relationship Open
Protein aggregation may lead to detrimental changes in brain and several other tissues. Amyloids or large protein aggregates are formed in different brain areas under multiple diseases classified as proteinopathies. However, our understand…
View article: The Ubiquitin Tale: Current Strategies and Future Challenges
The Ubiquitin Tale: Current Strategies and Future Challenges Open
Ubiquitin (Ub) is often considered a structurally conserved protein. Ubiquitination plays a prominent role in the regulation of physiological pathways. Since the first mention of Ub in protein degradation pathways, a plethora of nonproteol…
View article: Amyloids and brain cancer: molecular linkages and crossovers
Amyloids and brain cancer: molecular linkages and crossovers Open
Amyloids are high-order proteinaceous formations deposited in both intra- and extracellular spaces. These aggregates have tendencies to deregulate cellular physiology in multiple ways; for example, altered metabolism, mitochondrial dysfunc…
View article: Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Background The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technic…
View article: Additional file 4 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 4 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 4: Table S2. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from mouse cortices. Proteins identified with a higher abundance in purified fibrils (N = 8) obtained from AppNL-F/NL-F, and App…
View article: Additional file 8 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 8 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 8: Table S6. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from rat hippocampal and cortical neurons incubation recombinant Aβ42 seeds. Proteins identified in fibrils purified from rat co…
View article: Additional file 7 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 7 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 7: Table S5. List of proteins identified in multiplex TMT analysis of amyloid fibrils isolated from mouse of different age groups. Proteins identified in 16-plex TMT analysis containing eight biological conditions, each in …
View article: Additional file 6 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 6 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 6: Table S4. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from mouse and human cortices following multiprotease digestion. Proteins identified in purified fibrils following their additio…
View article: Additional file 9 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 9 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 9: Table S7. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from Aβ42 fly heads. Proteins identified with significantly higher levels in purified fibrils obtained from Aβ42 flies, compared…
View article: Additional file 5 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 5 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 5: Table S3. List of proteins identified in label free MS analysis of amyloid fibrils isolated from human AD cortices. Proteins with significantly higher abundance in purified fibrils obtained from human brain cortices, wit…
View article: Additional file 3 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Additional file 3 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity Open
Additional file 3: Table S1. Summary of the human subject brains. Overall, 1 control human brain tissues were used; age, gender, race and other relevant information is provided in sheet 1. For AD human samples, we obtained 13 and 23 human …
View article: Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases Open
Diclofenac is a highly prescribed non-steroidal anti-inflammatory drug (NSAID) that relieves inflammation, pain, fever, and aches, used at different doses depending on clinical conditions. This drug inhibits cyclooxygenase-1 and cyclooxyge…
View article: Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain Open
Proteinaceous fibrillar inclusions are key pathological hallmarks of multiple neurodegenerative diseases. In the early stages of Alzheimer's disease (AD), amyloid-beta peptides form protofibrils in the extracellular space, which act as see…
View article: Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go
Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go Open
Alzheimer's disease (AD) is characterized by the continuous decline of the cognitive abilities manifested due to the accumulation of large aggregates of amyloid-beta 42 (Aβ42), the formation of neurofibrillary tangles of hyper-phosphorylat…
View article: Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils
Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils Open
Leishmania , the causative agent of leishmaniasis, is an intracellular pathogen that thrives in the insect gut and mammalian macrophages to complete its life cycle. Apart from temperature difference (26 to 37°C), it encounters several hars…
View article: Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis
Gp78 E3 Ubiquitin Ligase: Essential Functions and Contributions in Proteostasis Open
As per the requirement of metabolism and fitness, normal cellular functions are controlled by several proteins, and their interactive molecular and signaling events at multiple levels. Protein quality control (PQC) mechanisms ensure the co…