Arunima Kapoor
YOU?
Author Swipe
View article: Age differences in spontaneous cerebrovascular reactivity at rest
Age differences in spontaneous cerebrovascular reactivity at rest Open
Deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) may indicate vulnerability to vascular dysfunction and cognitive impairment. Prior findings on age-related change in CVR are mixed, and no studies to date have inve…
View article: Development of the <scp>KeyStrokes</scp> test: An online neuropsychological assessment for attention, processing speed and executive function
Development of the <span>KeyStrokes</span> test: An online neuropsychological assessment for attention, processing speed and executive function Open
The ‘KeyStrokes’ test (KS) was created as an online and computerized neuropsychological assessment to assess simple attention, processing speed, and executive function. This pilot study aims to show proof of concept of the KS test as a com…
View article: Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers
Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers Open
Cerebral blood flow (CBF) deficits, cognitive decline, and brain structural changes have been reported in older adults with and without apolipoprotein E-e4 ( APOE4 )-related risk for dementia. However, it remains unclear whether brain stru…
View article: Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults
Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults Open
View article: Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers
Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers Open
View article: Elevated plasma neurofilament light and glial fibrillary acidic protein are associated with impaired cerebrovascular reactivity in older adults
Elevated plasma neurofilament light and glial fibrillary acidic protein are associated with impaired cerebrovascular reactivity in older adults Open
Background Plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) are markers of axonal and astroglial injury, respectively. Both markers have been proposed as predictive biomarkers of cerebral small vessel disease, wi…
View article: Central Autonomic Dysfunction and Plasma Ab<sub>42/40</sub>
Central Autonomic Dysfunction and Plasma Ab<sub>42/40</sub> Open
Background Higher order regulation of autonomic function is maintained by cortical and subcortical interconnected regions within the brain, collectively referred to as the central autonomic network (CAN) (Benarroch, 1993). Despite the well…
View article: Higher Cerebrovascular Reactivity Predicts Better Memory Function in Older Adults Without Dementia
Higher Cerebrovascular Reactivity Predicts Better Memory Function in Older Adults Without Dementia Open
Background Optimal cerebral blood flow is crucial to maintaining cognitive function. Cerebrovascular reactivity (CVR) is a dynamic measure of cerebrovascular function which represents the ability of cerebral blood vessels to regulate blood…
View article: Sex Differences in Cerebrovascular Reactivity to Hypercapnia in Older Adults
Sex Differences in Cerebrovascular Reactivity to Hypercapnia in Older Adults Open
Background Cerebrovascular reactivity (CVR) is a marker of cerebrovascular function defined by blood flow changes in response to vasoactive stimuli, which may represent a valuable indicator of risk for vascular brain injury and cognitive d…
View article: Plasma biomarkers of vascular injury and cerebrovascular reactivity in <i>APOE4</i> carriers
Plasma biomarkers of vascular injury and cerebrovascular reactivity in <i>APOE4</i> carriers Open
Background APOE4 carriers exhibit cerebrovascular dysfunction which may contribute to the development of cognitive decline and dementia; however, the mechanisms underlying this pathophysiology remain unknown. Impaired cerebrovascular react…
View article: Depression, Obstructive Sleep Apnea and Cognitive Impairment (DOC) Screen Completion Time Reflects Executive Function, Speed of Processing and Fluency
Depression, Obstructive Sleep Apnea and Cognitive Impairment (DOC) Screen Completion Time Reflects Executive Function, Speed of Processing and Fluency Open
Background: The depression, obstructive sleep apnea and cognitive impairment (DOC) screen assesses three post-stroke comorbidities, but additional information may be gained from the time to complete the screen. Cognitive screening completi…
View article: Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits
Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits Open
INTRODUCTION Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with…
View article: Reliability of beat-to-beat blood pressure variability in older adults
Reliability of beat-to-beat blood pressure variability in older adults Open
View article: Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults
Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults Open
Visit-to-visit blood pressure variability (BPV) predicts age-related hippocampal atrophy, neurodegeneration, and memory decline in older adults. Beat-to-beat BPV may represent a more reliable and efficient tool for prospective risk assessm…
View article: Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity
Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity Open
ocial isolation is associated with increased risk for stroke and cognitive decline. 1 Although existing research has proposed neuroimmune system dysregulation as a possible underlying mechanism, 1 few studies have investigated cerebrovascu…
View article: Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits
Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits Open
Background Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with M…
View article: Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults
Central autonomic network dysfunction and plasma Alzheimer’s disease biomarkers in older adults Open
View article: The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults
The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults Open
Blood pressure variability (BPV) and arterial stiffness are age-related hemodynamic risk factors for neurodegenerative disease, but it remains unclear whether they exert independent or interactive effects on brain health. When combined wit…
View article: Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small‐Vessel Disease in <i>APOE4</i> Carriers
Blood Pressure Variability, Central Autonomic Network Dysfunction, and Cerebral Small‐Vessel Disease in <i>APOE4</i> Carriers Open
View article: Reliability of beat-to-beat blood pressure variability in older adults
Reliability of beat-to-beat blood pressure variability in older adults Open
Blood pressure variability (BPV) is emerging as an important risk factor across numerous disease states, including cerebrovascular and neurodegenerative disease in older adults. However, there is no current consensus regarding specific use…
View article: Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults
Robust reference group normative data for neuropsychological tests accounting for primary language use in Asian American older adults Open
Objective: The present study aimed to develop neuropsychological norms for older Asian Americans with English as a primary or secondary language, using data from the National Alzheimer’s Coordinating Center (NACC). Method: A normative samp…
View article: Short-term blood pressure variability and brain functional network connectivity in older adults
Short-term blood pressure variability and brain functional network connectivity in older adults Open
Older adults with elevated short-term blood pressure variability exhibit lower resting state functional connectivity in the default network. Findings support the role of blood pressure variability in neurovascular dysfunction and Alzheimer…
View article: Perivascular Spaces in the Basal Ganglia Disrupt Fronto-Parietal Network Connectivity in Older Adults
Perivascular Spaces in the Basal Ganglia Disrupt Fronto-Parietal Network Connectivity in Older Adults Open
Introduction: Perivascular spaces (PVS) support clearance of metabolic waste and interstitial fluid from the brain. Enlarged PVS in the basal ganglia (BG-PVS) are a feature of small vessel disease and associated with increased risk of cogn…
View article: Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers
Blood pressure variability, central autonomic network dysfunction and cerebral small vessel disease in APOE4 carriers Open
Background Increased blood pressure variability (BPV) is a risk factor for cerebral small vessel disease (CSVD) and neurodegeneration, independent of age and average blood pressure, particularly in apolipoprotein E4 ( APOE4 ) carriers. How…
View article: Emotional Enhancement of Memory in Alzheimer’s Disease: A Systematic Review
Emotional Enhancement of Memory in Alzheimer’s Disease: A Systematic Review Open
Background Progressive decline in episodic memory is a hallmark of Alzheimer’s disease (AD). Emotional arousal is known to enhance memory. The amygdala, locus coeruleus, hippocampus, and other regions, are key brain structures involved in …
View article: <i>APOE4</i> Carriers with Perivascular Spaces Exhibit Altered Cerebral Blood Flow
<i>APOE4</i> Carriers with Perivascular Spaces Exhibit Altered Cerebral Blood Flow Open
Background Perivascular spaces (PVS) are fluid‐filled spaces surrounding arterioles, capillaries and venules in the brain, which support metabolic waste clearance. Enlarged PVS are associated with increased dementia risk. Changes in arteri…
View article: APOE4 Carriers with Perivascular Spaces Exhibit Altered Cerebral Blood Flow
APOE4 Carriers with Perivascular Spaces Exhibit Altered Cerebral Blood Flow Open
Background Perivascular spaces (PVS) are fluid‐filled spaces surrounding arterioles, capillaries and venules in the brain, which support metabolic waste clearance. Enlarged PVS are associated with increased dementia risk. Changes in arteri…
View article: Blood pressure variability and functional network connectivity in older adults
Blood pressure variability and functional network connectivity in older adults Open
Background Blood pressure variability is an emerging risk indicator for cerebrovascular disease and Alzheimer’s disease, independent of traditionally studied mean blood pressure levels. Recent studies suggest elevated blood pressure variab…
View article: Locus coeruleus integrity, cerebrovascular health, and plasma Alzheimer’s biomarkers in cognitive aging
Locus coeruleus integrity, cerebrovascular health, and plasma Alzheimer’s biomarkers in cognitive aging Open
Background The locus coeruleus (LC) innervates the cerebrovasculature and plays a critical role in optimally regulating cerebral blood flow. However, few studies have examined potential relationships between these systems in humans with wi…
View article: 32 Elevated Plasma pTau-181 is Associated with Lower Global Cognition and Executive Function in Older Adults
32 Elevated Plasma pTau-181 is Associated with Lower Global Cognition and Executive Function in Older Adults Open
Objective: Aggregation of phosphorylated tau (pTau) is a hallmark feature of Alzheimer’s disease (AD). Novel assays now allow pTau to be measured in plasma. Elevated plasma pTau predicts subsequent development of AD, cortical atrophy and A…