Atul Gupta
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View article: Protocol for an open labelled observational study in children & adolescents with severe asthma with an eosinophilic phenotype treated with mepolizumab (CASAM)
Protocol for an open labelled observational study in children & adolescents with severe asthma with an eosinophilic phenotype treated with mepolizumab (CASAM) Open
Introduction Children with severe eosinophilic asthma are at an increased risk of severe exacerbations, medication side effects, impaired lung function, and significantly reduced quality of life. The advent of biologic agents aimed at eosi…
View article: Redefining cardiac risk in breast radiotherapy: a substructure-based dosimetric and biomarker correlation study
Redefining cardiac risk in breast radiotherapy: a substructure-based dosimetric and biomarker correlation study Open
Our findings confirm that MHD is an inadequate surrogate for predicting the heterogeneous dose distribution among cardiac substructures. Elevated NT-proBNP levels and reduced EF were significantly associated with higher substructure doses,…
View article: Demographic Variations in Immune Checkpoint Inhibitor Adverse Events: A Real-World Study
Demographic Variations in Immune Checkpoint Inhibitor Adverse Events: A Real-World Study Open
Advanced age showed a protective effect on cytopenias. Hispanics had reduced anemia and dermatitis risk; African Americans and females had higher neutropenia, and obesity was linked to dermatitis. These findings may aid clinicians in perso…
View article: Multi-Relation Extraction in Entity Pairs using Global Context
Multi-Relation Extraction in Entity Pairs using Global Context Open
In document-level relation extraction, entities may appear multiple times in a document, and their relationships can shift from one context to another. Accurate prediction of the relationship between two entities across an entire document …
View article: Biportal Endoscopic Intervention for Lumbar Disk Herniation: Evaluating Clinical Effectiveness and Patient Outcomes
Biportal Endoscopic Intervention for Lumbar Disk Herniation: Evaluating Clinical Effectiveness and Patient Outcomes Open
Aims and background: Lumbar disk herniation (LDH) affects millions worldwide, spurring advancements in treatment. Biportal endoscopic spinal surgery (BESS) emerges as a promising approach, minimizing invasiveness. BESS employs specialized …
View article: Oral Inhaled Cromolyn for Mild-to-Moderate Amyotrophic Lateral Sclerosis: A Randomized, Open Label Phase 2a Study
Oral Inhaled Cromolyn for Mild-to-Moderate Amyotrophic Lateral Sclerosis: A Randomized, Open Label Phase 2a Study Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of the motor neuron system for which there is currently no effective treatment. This study aims to evaluate the safety and efficacy of two doses of oral inhale…
View article: Induction Chemotherapy: Hope or Hype in Head & Neck Cancer - An Audit from Institute of National Importance in Western Rajasthan & Review of Literature
Induction Chemotherapy: Hope or Hype in Head & Neck Cancer - An Audit from Institute of National Importance in Western Rajasthan & Review of Literature Open
Head and Neck Cancers (HNCs) are malignant tumours of the upper aerodigestive tract which includes subsites as the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx. Squamous cell carcinoma (SCC) constitutes for >90% of HNCs. T…
View article: Technological Advances in Radiation Oncology
Technological Advances in Radiation Oncology Open
One of the most technologically advanced treatment modalities for cancer is radiotherapy (RT). Because of advancements in computer and engineering over the past few decades, RT approaches have undergone significant modification. Our goal i…
View article: Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma
Patient-centred composite scores as tools for assessment of response to biological therapy for paediatric and adult severe asthma Open
Background We have previously developed Core Outcome Measures sets for Severe Asthma (COMSA) by multi-stakeholder consensus. There are no patient-centred tools to quantify response to biological therapies for severe asthma. We aimed to dev…
View article: Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial
Treating severe paediatric asthma with mepolizumab or omalizumab: a protocol for the TREAT randomised non-inferiority trial Open
Introduction A minority of school-aged children with asthma have persistent poor control and experience frequent asthma attacks despite maximal prescribed maintenance therapy. These children have higher morbidity and risk of death. The fir…
View article: Respiratory management of acute chest syndrome in children with sickle cell disease
Respiratory management of acute chest syndrome in children with sickle cell disease Open
Acute chest syndrome (ACS) is a leading cause of respiratory distress and hospitalisation in children with sickle cell disease (SCD). The aetiology is multifactorial and includes fat embolism, venous thromboembolism, alveolar hypoventilati…
View article: High-flow humidified oxygen as an early intervention in children with acute severe asthma: a feasibility randomised controlled trial
High-flow humidified oxygen as an early intervention in children with acute severe asthma: a feasibility randomised controlled trial Open
Background Treating children with acute severe asthma (ASA) who fail to respond to first-line inhaled bronchodilators is problematic: use of intravenous agents is inconsistent and side-effects are common. High-flow humidified oxygen (HiFlo…
View article: Role of nebulised magnesium sulfate in treating acute asthma in children: a systematic review and meta-analysis
Role of nebulised magnesium sulfate in treating acute asthma in children: a systematic review and meta-analysis Open
Objectives To review the efficacy of nebulised magnesium sulfate (MgSO 4 ) in acute asthma in children. Methods The authors searched Medline, Embase, Web of Science and Cochrane Library for randomised controlled trials (RCTs) published unt…
View article: Can Non-invasive Hormone Profiling in Female Tigers (Panthera tigris) could Differentiate True Pregnancy and Pseudopregnancy
Can Non-invasive Hormone Profiling in Female Tigers (Panthera tigris) could Differentiate True Pregnancy and Pseudopregnancy Open
Background: The tigers (Panthera tigris) being the world’s largest cat are one of the critically endangered species which are at the verge of extinction. The pseudopregnancy or false pregnancy or pseudocyesis is a syndrome which is charact…
View article: Impact of Lung Function on Asthma Exacerbation Rates in Children Treated with Dupilumab: The VOYAGE Study
Impact of Lung Function on Asthma Exacerbation Rates in Children Treated with Dupilumab: The VOYAGE Study Open
NCT02948959.
View article: High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial
High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial Open
Background Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to …
View article: High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial (Preprint)
High-Flow Humidified Oxygen as an Early Intervention in Children With Acute Severe Asthma: Protocol for a Feasibility Randomized Controlled Trial (Preprint) Open
BACKGROUND Acute severe asthma (ASA) is a leading cause of hospital attendance in children. Standard first-line therapy consists of high-dose inhaled bronchodilators plus oral corticosteroids. Treatment for children who fail to respond to…
View article: Definitions of non-response and response to biological therapy for severe asthma: a systematic review
Definitions of non-response and response to biological therapy for severe asthma: a systematic review Open
Background Biologics have proven efficacy for patients with severe asthma but there is lack of consensus on defining response. We systematically reviewed and appraised methodologically developed, defined and evaluated definitions of non-re…
View article: Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)
Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA) Open
Background Effectiveness studies with biological therapies for asthma lack standardised outcome measures. The COMSA (Core Outcome Measures sets for paediatric and adult Severe Asthma) Working Group sought to develop Core Outcome Measures (…
View article: Assessing Seroprevalence of Major Viral Infections in Big Cats
Assessing Seroprevalence of Major Viral Infections in Big Cats Open
Background: Big cats are widespread across the globe and India is also the host of this group of animals. Canine distemper virus (CDV), a morbillivirus that causes one of the most contagious and lethal viral diseases known in canids, has a…
View article: Sociodemographic status of elderly & pattern of health care utilization for respiratory diseases in NCR
Sociodemographic status of elderly & pattern of health care utilization for respiratory diseases in NCR Open
Elderly population is increasing progressively all over the world. Diseases of respiratory system are important cause of morbidity & mortality in elderly. Health-care utilization is an important element of health care. Cross-sectional stud…
View article: Outcomes in patients of pulmonary tuberculosis treated under RNTCP & follow up after 6 months
Outcomes in patients of pulmonary tuberculosis treated under RNTCP & follow up after 6 months Open
Tuberculosis (TB) is, one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent. This Prospective study was conducted at Santosh medical college Ghaziabad from 1 April 2018 to 30 September 20…