Aruto Nakajima
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View article: Human milk oligosaccharides and infant gut microbiome in Mongolian mother-infant dyads
Human milk oligosaccharides and infant gut microbiome in Mongolian mother-infant dyads Open
Human milk oligosaccharides (HMO) play crucial roles in establishing a healthy gut microbiota in breastfed infants. Many studies have been conducted using samples collected in different areas with varying lifestyles to examine the relation…
View article: Ecological insights into the assembly of bifidobacterial communities in the infant gut
Ecological insights into the assembly of bifidobacterial communities in the infant gut Open
The initial community assembly of the gut microbiome during infancy significantly influences its development over time. Strains of the genus Bifidobacterium are some of the early colonizers in the infant gut and a commonly used probiotic t…
View article: Uptake of fucosylated type I human milk oligosaccharide blocks by <i>Bifidobacterium longum</i> subsp. <i>infantis</i>
Uptake of fucosylated type I human milk oligosaccharide blocks by <i>Bifidobacterium longum</i> subsp. <i>infantis</i> Open
Human milk oligosaccharides (HMOs) are uniquely rich in the type 1 building block disaccharide lacto- N -biose I (LNB; Galβ1,3GlcNAc), as compared to other mammals. Most HMOs are fucosylated, for example, α1,2 and α1,4 fucosylations on LNB…
View article: <i>In vitro</i> competition with <i>Bifidobacterium</i> strains impairs potentially pathogenic growth of <i>Clostridium perfringens</i> on 2′-fucosyllactose
<i>In vitro</i> competition with <i>Bifidobacterium</i> strains impairs potentially pathogenic growth of <i>Clostridium perfringens</i> on 2′-fucosyllactose Open
Fortifying infant formula with human milk oligosaccharides, such as 2'-fucosyllactose (2'-FL), is a global trend. Previous studies have shown the inability of pathogenic gut microbes to utilize 2'-FL. However, the present study demonstrate…
View article: Uptake of fucosylated type I human milk oligosaccharide blocks by<i>Bifidobacterium longum</i>subsp.<i>infantis</i>
Uptake of fucosylated type I human milk oligosaccharide blocks by<i>Bifidobacterium longum</i>subsp.<i>infantis</i> Open
Human milk oligosaccharides (HMOs) are uniquely rich in the type 1 building block disaccharide lacto- N -biose I (LNB, Galβ1,3GlcNAc), as compared to other mammals. Most HMOs are fucosylated, e.g. , α1,2 and α1,4 fucosylations on LNB block…
View article: Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol
Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol Open
Oral sesamol supplementation in mice suppressed fecal phenol production, partly by inhibiting bacterial l -tyrosine phenol-lyase, suggesting its potential to prevent physiological disorders linked to fecal phenol.
View article: Human gut-associated <i>Bifidobacterium</i> species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan
Human gut-associated <i>Bifidobacterium</i> species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan Open
Indole in the gut is formed from dietary tryptophan by a bacterial tryptophan-indole lyase. Indole not only triggers biofilm formation and antibiotic resistance in gut microbes but also contributes to the progression of kidney dysfunction …
View article: Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR
Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria Is Governed by Global Transcriptional Regulator NagR Open
The predominance of bifidobacteria in the gut of breastfed infants is attributed to the ability of these bacteria to metabolize human milk oligosaccharides (HMOs). Thus, individual HMOs such as lacto- N -tetraose (LNT) and lacto- N -neotet…
View article: Priority effects shape the structure of infant-type <i>Bifidobacterium</i> communities on human milk oligosaccharides
Priority effects shape the structure of infant-type <i>Bifidobacterium</i> communities on human milk oligosaccharides Open
Bifidobacteria are among the first colonizers of the infant gut, and human milk oligosaccharides (HMOs) in breastmilk are instrumental for the formation of a bifidobacteria-rich microbiota. However, little is known about the assembly of bi…
View article: Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagR
Human Milk Oligosaccharide Utilization in Intestinal Bifidobacteria is Governed by a Global Transcriptional Regulator NagR Open
Bifidobacterium longum subsp. infantis ( B. infantis ) is a prevalent beneficial bacterium that colonizes the human neonatal gut and is uniquely adapted to efficiently use human milk oligosaccharides (HMOs) as a carbon and energy source. M…
View article: Diversification of a Fucosyllactose Transporter within the Genus <i>Bifidobacterium</i>
Diversification of a Fucosyllactose Transporter within the Genus <i>Bifidobacterium</i> Open
Human milk oligosaccharides (HMOs), which are natural bifidogenic prebiotics, were recently commercialized to fortify formula milk. However, HMO assimilation phenotypes of bifidobacteria vary by species and strain, which has not been fully…
View article: A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer)
A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer) Open
Aim: 16S rRNA gene-based microbiota analyses (16S metagenomes) using next-generation sequencing (NGS) technologies are widely used to examine the microbial community composition in environmental samples. However, the sequencing capacity of…