Arvind Bhake
YOU?
Author Swipe
Expression of CXCR-4 and CD 133 and it’s Correlation with Prognostic Pathologic Factors in Resectable Oral Squamous Cell Carcinoma: A Research Protocol Open
Introduction: Cancer Stem Cells (CSCs), known for their selfrenewal and resistance to therapy, drive tumour progression, metastasis, and recurrence. Markers such as Cluster of Differentiation 133 (CD133) and CXC Chemokine Receptor-4 (CXCR-…
The cytodiagnosis of metastasis of follicular thyroid carcinoma in the scalp: an unusual case report Open
Follicular thyroid carcinoma is known to metastasize to distant places even before the primary follicular thyroid carcinoma is clinically obvious. One such unusual and distant metastasis of follicular thyroid carcinoma is its subcutaneous …
Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review Open
Endometrial carcinoma is one of the important health issues addressed globally. Therefore, understanding the molecular pathogenesis of endometrial carcinoma for the purpose of prognostic and predictive markers remains in the centre of rese…
Mutational Analysis of BRAFV600E by Polymerase Chain Reaction in Breast Cancer: A Narrative Review Open
A major cause of cancer-related death for women globally is breast cancer, calling for molecular insights to better prognosis and treatment. One of the genetic changes that contributes to the constitutive activation of the MAPK/ERK (mitoge…
Clinicopathology of Triple-negative Breast Cancer: A Study from Tertiary Care Hospital of Central India Open
Background: The triple-negative breast cancer (TNBC) is a unique molecular subtype of invasive ductal carcinoma that bears the characters of aggressive biological behavior, high Bloom Richardson grade, and high tumor, node, and metastasis …
Malignant Melanoma in the Groin Masquerading as a Vascular Tumour: A Rare Cytodiagnosis Open
Malignant melanoma (MM) is an aggressive cutaneous neoplasm tending to metastasise anywhere within the body. It frequently metastasises to the draining lymph nodes. A distinct presentation of MM occurs when metastatic lesions appear in the…
Assessing and Evaluating HbS Concentration in Asymptomatic Sickle Cell Patients and Patients With Sickle Cell Crisis Through High-Performance Liquid Chromatography (HPLC) in a Tertiary Hospital in Central India Open
Background Sickle cell disease (SCD) is a significant health concern, particularly due to the variability in disease severity and frequency of crisis episodes among patients. Accurate assessment of HbS concentrations is crucial for underst…
Detection of KRAS Mutations in Triple-negative Breast Cancers by Polymerase Chain Reaction Open
Background: Recently, it has been proven that KRAS gene mutation analysis is an additional in vitro diagnostic method for determining colorectal cancer patients who will not respond to anti-epidermal growth factor receptor (EGFR) therapy. …
Cytodiagnosis of Metastatic Thyroid Follicular Carcinoma in Left Iliac Bone with Occult Primary: A Case Report Open
Bone metastasis of Follicular Thyroid Carcinoma (FTC) is an aggressive complication. Typically, follicular carcinoma remains confined to the thyroid gland, with distant metastasis occurring in 4-15% of cases. The lungs are the most frequen…
Cytodiagnosis of Telangiectatic Osteosarcoma in a Patient with Previous Fracture Humerus Surgery with Plating: A Case Report Open
Telangiectatic Osteosarcoma (TO) is a rare variant of osteosarcoma, accounting for 0.4-12% of cases. It is a high-grade malignancy occurring in adolescence and the adult population. It commonly occurs in the bones of the limbs but rarely i…
View article: A Case of Breast Cancer with Neuroendocrine Differentiation
A Case of Breast Cancer with Neuroendocrine Differentiation Open
A very uncommon and different subtype of breast cancer with particular morphological and molecular characteristics is Neuroendocrine Carcinoma of the Breast (NECB). A 59-year-old female patient presented to the Department of Surgery with a…
Cytodiagnosis of Oncocytoma of Parotid Gland: A Report of Two Cases Open
Among benign neoplasms of the salivary gland, malignancies are less common. One of the rarest tumours found in the oral cavity is oncocytoma, comprising less than 2% of all oral neoplasms and carrying a 1% risk of malignant transformation.…
Cytodiagnosis of Spindle Cell Squamous Cell Carcinoma presenting as a Metastatic Lesion to Chest Wall: A Case Report Open
Spindle cell carcinoma is a rare biphasic tumour composed of squamous cell epithelial and spindle cell mesenchymal components. This variant of squamous cell carcinoma masquerades as sarcoma with a high-risk of recurrence and metastasis. Me…
Case Report: Cytodiagnosis of pigmented villonodular synovitis involving carpal bones of right wrist Open
Background Pigmented Villonodular Synovitis (PVNS) is a rare disease of osteoskeletal tissue. Cytodiagnosis of PVNS on fine needle aspiration (FNA) smears is therefore rarely reported. The PVNS usually affects the larger joints. The involv…
Case Report: Cytodiagnosis of primitive neuroectodermal tumor (PNET) of sinonasal tract Open
Malignant sinonasal tumors are rarely encountered in the practice of oncology as they constitute only 1% of total body tumors. The occurrence of primitive neuroectodermal tumor (PNET) in the sinonasal tract is even more uncommon. The PNET …
Utility of Perl’s Prussian Blue Stain in Exfoliated Buccal Cells of Thalassemia and Sickle Cell Anemia Patients and Their Correlation With Serum Ferritin Levels Open
Introduction Iron is essential for all living beings. Excess iron, on the other hand, is dangerous because it causes the creation of free radicals. As a result, iron absorption is carefully managed to maintain a balance between absorption …
Invasive Acantholytic Ocular Surface Squamous Neoplasia: A Rare Case Open
Ocular surface squamous neoplasia (OSSN) is a spectrum of intraepithelial and invasive neoplastic lesions of the conjunctiva and cornea. OSSN is a rare but potentially sight-threatening ocular malignancy that can be challenging to diagnose…
Hemoglobin Variants in Patients With Microcytic Hypochromic Anemia: A Review of Indian Studies Open
Microcytic hypochromic (MCHC) anemia with hemolytic components is common in clinical practice. Hemoglobinopathies and variants are one of the important underlying causes of MCHC anemia. The Indian population, by large, as various studies r…
Cytodiagnosis of Basal Cell Adenoma of Parotid Gland: A Rare Case Report Open
Basal cell adenoma is a rare benign neoplastic lesion of the parotid gland, therefore it is rarely diagnosed in preoperative work-up by fine needle aspiration cytology. This distinctive entity being regarded as one of the scarce salivary n…
Bcl-2 Immunoexpression in Invasive Ductal Carcinoma and Its Evaluative Correlation with Molecular Sub-Types and BR-Grade and TNM Stage Open
Invasive Ductal carcinoma is the most common histological type of breast cancer. It constitutes about 80 percent of all breast cancer diagnoses. The molecular pathogenesis of breast cancer involves multiple gene types. Bcl-2 is one of them…
Cytodiagnosis of pleomorphic adenoma in ectopic salivary gland in neck: a case report Open
Encounter with ectopic salivary is a rarity in clinical practice. The ectopic salivary tissue harbouring neoplastic pathology is infrequent phenomenon. The literature reports about are scarce. The present case report is unique for the reas…
PTEN Immunoexpression in Atypical Endometrial Hyperplasia and Endometrioid Endometrial Carcinoma: A Research Protocol Open
Introduction: One of the major cancers affecting women is of Endometrial Carcinoma (EC). Therefore, its molecular characterisation remains important. Phosphatase and Tensin Homolog (PTEN) gene defects are one such molecular pathology commo…
Immunoprofiling of BRAFV600E in Precancerous and Cancerous Lesions of Breast by Immunohistochemistry and its Association with Clinicopathological Features Open
Introduction: Breast carcinoma in women is one of the few causes of morbidity and mortality which concerns the health providers. The molecular basis of breast carcinoma in recent years has provided the insight for the genesis of carcinoma,…
Analysis of BRAF V600E in Precancerous and Cancerous Lesions of Colorectum by Immunohistochemistry: A Research Protocol Open
Introduction: Colorectal cancers have been extensively studied in recent years to understand their molecular abnormalities and their impact on treatment outcomes, as they continue to be a major global health burden. The Adenomatous Polypos…
Cytodiagnosis of Warthin’s Tumour in Submandibular Salivary GlandA Rare Case Report Open
The cytodiagnosis of Warthin’s tumour by Fine Needle Aspiration Cytology (FNAC) in the submandibular salivary gland in literature is sparsely reported. Constituting an outnumbered portion of salivary gland neoplasms, it is a monomorphic ad…
Management of Uterine Fibroids and Its Complications During Pregnancy: A Review of Literature Open
The word "uterine fibroids" itself indicates these are leiomyomas (a group of smooth muscle tumors that are benign), generally growing in the wall of the uterus. Nowadays, this is one of the most common diseases in women in the premenopaus…
A Study of Bcl-2 Immuno-expression in Invasive Ductal Carcinoma of Breast and it’s Correlation with Molecular Sub-types Open
Background: The incidence of Breast cancers has overtaken the cervical cancers amongst Indian females. Invasive Ductal carcinoma is reported to be the most common form of breast cancer. Bcl-2 has been studied extensively as a common factor…