Arvind Shakya
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View article: Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders
Discovery of a PDE4B and PDE4D selective bifunctional degrader for management of chronic inflammatory disorders Open
View article: Methoxyfenozide as a potent insect growth regulator: Disruption of growth, development and chitin synthesis in <i>Aedes aegypti</i> for sustainable vector control
Methoxyfenozide as a potent insect growth regulator: Disruption of growth, development and chitin synthesis in <i>Aedes aegypti</i> for sustainable vector control Open
Aedes aegypti is a major vector of arboviral diseases such as dengue, chikungunya, Zika, and yellow fever. Traditional chemical insecticides have led to widespread insecticide resistance and posed risks to non-target organisms and the envi…
View article: Discovery of a Pde4b and Pde4d Selective Bifunctional Degrader for Management of Chronic Inflammatory Disorders
Discovery of a Pde4b and Pde4d Selective Bifunctional Degrader for Management of Chronic Inflammatory Disorders Open
View article: Supplementary Table S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S4 displays the IC50 values for BTX-6654 and BTX-7312 from all 3D proliferation assays examined in this study
View article: Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S5 demonstrates the synergistic effects of combining BTX-7312 with inhibitors of the RTK-RAS-MAPK pathway
View article: Supplementary Table S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S5 shows the IC50 values for SOS1 inhibitors in 3D proliferation assays for KRAS G12D cell lines
View article: Supplementary Table S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table 2 lists all the antibodies used in this study for Western Blot experiments
View article: Supplementary Table S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S5 shows the IC50 values for SOS1 inhibitors in 3D proliferation assays for KRAS G12D cell lines
View article: Supplementary Methods from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Methods from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Methods describes the synthesis of compounds used in this study
View article: Data from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Data from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Mutations within the oncogene KRAS drive an estimated 25% of all cancers. Only allele-specific KRAS G12C inhibitors are currently available and are associated with the emergence of acquired resistance, partly due to upstream …
View article: Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S4 summarizes the exposure and changes of body weight for BTX-6654-treated mice
View article: Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S4 summarizes the exposure and changes of body weight for BTX-6654-treated mice
View article: Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S5 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S5 demonstrates the synergistic effects of combining BTX-7312 with inhibitors of the RTK-RAS-MAPK pathway
View article: Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S1 displays the effects of SOS1 degraders on SOS1-complex interactors and neosusbstrates
View article: Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S2 shows the degradation-driven antiproliferative activity of BTX-6654 and BTX-7312 in K562 cells
View article: Data from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Data from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Mutations within the oncogene KRAS drive an estimated 25% of all cancers. Only allele-specific KRAS G12C inhibitors are currently available and are associated with the emergence of acquired resistance, partly due to upstream …
View article: Supplementary Table S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S3 lists the EC50 and IC50 values for ternary complex formation and SOS1 binding for compounds used in this study
View article: Supplementary Figure S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S3 demonstrates the effects of genetic depletion of SOS1 in MIA PaCa-2 3D growth
View article: Supplementary Table S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table 1 shows all the cell lines used in this study along with purchasing information as well as conditions for cell culture
View article: Supplementary Table S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S3 lists the EC50 and IC50 values for ternary complex formation and SOS1 binding for compounds used in this study
View article: Supplementary Methods from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Methods from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Methods describes the synthesis of compounds used in this study
View article: Supplementary Table S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S4 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table S4 displays the IC50 values for BTX-6654 and BTX-7312 from all 3D proliferation assays examined in this study
View article: Supplementary Table S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table 1 shows all the cell lines used in this study along with purchasing information as well as conditions for cell culture
View article: Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S2 shows the degradation-driven antiproliferative activity of BTX-6654 and BTX-7312 in K562 cells
View article: Supplementary Figure S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S3 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S3 demonstrates the effects of genetic depletion of SOS1 in MIA PaCa-2 3D growth
View article: Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Figure S1 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Figure S1 displays the effects of SOS1 degraders on SOS1-complex interactors and neosusbstrates
View article: Supplementary Table S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth
Supplementary Table S2 from Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple <i>KRAS</i> Mutations and Inhibits Tumor Growth Open
Supplementary Table 2 lists all the antibodies used in this study for Western Blot experiments
View article: Anti-cancer Potential of Bioactive Compounds from Moringa oleifera against PARK2 in Oral Cancer protein: In silico Approach
Anti-cancer Potential of Bioactive Compounds from Moringa oleifera against PARK2 in Oral Cancer protein: In silico Approach Open
Background: Globally, oral cancer (OC) is one of the most common cancers and it is the second highest incidence in India. Medicinal plants are well known anticancer therapeutic agents since ages and considered alternative treatment of canc…
View article: Evaluation of the Stability and Fate of Biogenic Selenium-Laden Waste Generated as Treatment Residual in Selenium Removing Sulfidogenic Bioreactors
Evaluation of the Stability and Fate of Biogenic Selenium-Laden Waste Generated as Treatment Residual in Selenium Removing Sulfidogenic Bioreactors Open
View article: In vitro antioxidant and nephroprotective properties of Polyalthia longifolia: A traditional medicinal plant
In vitro antioxidant and nephroprotective properties of Polyalthia longifolia: A traditional medicinal plant Open
Polyalthia longifolia (Sonn.) Thwaites is a traditional medicinal plant with diverse medicinal properties including kidney protection. The present investigation was aimed to assess the phytochemical content, antioxidant activity and evalua…