Aryan Kamal
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View article: Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis Open
View article: The remission status of AML patients after allo-HCT is associated with a distinct single-cell bone marrow T-cell signature
The remission status of AML patients after allo-HCT is associated with a distinct single-cell bone marrow T-cell signature Open
Acute myeloid leukemia (AML) is a hematologic malignancy for which allogeneic hematopoietic cell transplantation (allo-HCT) often remains the only curative therapeutic approach. However, incapability of T cells to recognize and eliminate r…
View article: Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension
Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension Open
View article: <scp>GRaNIE</scp> and <scp>GRaNPA</scp>: inference and evaluation of enhancer‐mediated gene regulatory networks
<span>GRaNIE</span> and <span>GRaNPA</span>: inference and evaluation of enhancer‐mediated gene regulatory networks Open
Enhancers play a vital role in gene regulation and are critical in mediating the impact of noncoding genetic variants associated with complex traits. Enhancer activity is a cell‐type‐specific process regulated by transcription factors (TFs…
View article: Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database
Pan-cancer analysis of microRNA expression profiles highlights microRNAs enriched in normal body cells as effective suppressors of multiple tumor types: A study based on TCGA database Open
Background MicroRNAs (miRNAs) are frequently deregulated in various types of cancer. While antisense oligonucleotides are used to block oncomiRs, delivery of tumour-suppressive miRNAs holds great potential as a potent anti-cancer strategy.…
View article: GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages
GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages Open
Among the biggest challenges in the post-GWAS (genome-wide association studies) era is the interpretation of disease-associated genetic variants in non-coding genomic regions. Enhancers have emerged as key players in mediating the effect o…
View article: A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages
A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages Open
Breast cancer (BC) as a leading cause of cancer death among women, exhibits a wide range of genetic heterogeneity in affected individuals. Satisfactory management of BC depends on early diagnosis and proper monitoring of patients' response…
View article: A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages
A novel panel of blood-based microRNAs capable of discrimination between benign breast disease and breast cancer at early stages Open
Breast cancer (BC) as a leading cause of cancer death among women, exhibits a wide range of genetic heterogeneity in affected individuals. Satisfactory management of BC depends on early diagnosis and proper monitoring of patients’ response…
View article: Cell Identity Codes: Understanding Cell Identity from Gene Expression Profiles using Deep Neural Networks
Cell Identity Codes: Understanding Cell Identity from Gene Expression Profiles using Deep Neural Networks Open
View article: Cell Identity Codes: Understanding Cell Identity from Gene Expression\n Profiles using Deep Neural Networks
Cell Identity Codes: Understanding Cell Identity from Gene Expression\n Profiles using Deep Neural Networks Open
Understanding cell identity is an important task in many biomedical areas.\nExpression patterns of specific marker genes have been used to characterize\nsome limited cell types, but exclusive markers are not available for many cell\ntypes.…