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View article: The relationship between sperm secretion and the Hippo signaling pathway in the rat seminiferous tubules
The relationship between sperm secretion and the Hippo signaling pathway in the rat seminiferous tubules Open
The Hippo signaling pathway has been demonstrated to be crucial in many stages such as cell division, death, or proliferation. Studies have also shown that the Hippo pathway is highly influenced by actin proteins and cytoskeletons. The eff…
View article: Lycopene enriched extra virgin olive oil: Biological activities and assessment of security profile on cells
Lycopene enriched extra virgin olive oil: Biological activities and assessment of security profile on cells Open
The production of tomato products is massive in Italy resulting in a huge amount of tomato waste as seeds, peels and stems. The aim of our work is to re-utilize these matrices through the extraction of carotenoids, especially lycopene to o…
View article: Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor
Discovery and Anticancer Screening of Novel Oxindole-Based Derivative Bearing Pyridyl Group as Potent and Selective Dual FLT3/CDK2 Kinase Inhibitor Open
Protein kinases regulate cellular activities and make up over 60% of oncoproteins and proto-oncoproteins. Among these kinases, FLT3 is a member of class III receptor tyrosine kinase family which is abundantly expressed in individuals with …
View article: Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells
Combination of an Oxindole Derivative with (−)-β-Elemene Alters Cell Death Pathways in FLT3/ITD+ Acute Myeloid Leukemia Cells Open
Acute myeloid leukemia (AML) is one of the cancers that grow most aggressively. The challenges in AML management are huge, despite many treatment options. Mutations in FLT3 tyrosine kinase receptors make the currently available therapies l…
View article: P-343 The role of Yes-Associated protein (YAP) activity in uterus adenogenesis process
P-343 The role of Yes-Associated protein (YAP) activity in uterus adenogenesis process Open
Study question Could Yes-Associated protein(YAP) be effective in the adenogenesis process that occurs in the mouse uterus in the postnatal period? Summary answer It was observed that the YAP and phospho-YAP levels decreased in mice with in…
View article: Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity
Vanillin-Based Indolin-2-one Derivative Bearing a Pyridyl Moiety as a Promising Anti-Breast Cancer Agent via Anti-Estrogenic Activity Open
The structure-based design introduced indoles as an essential motif in designing new selective estrogen receptor modulators employed for treating breast cancer. Therefore, here, a series of synthesized vanillin-substituted indolin-2-ones w…
View article: Expression analysis of Akirin-2, NFκB-p65 and β-catenin proteins in imatinib resistance of chronic myeloid leukemia
Expression analysis of Akirin-2, NFκB-p65 and β-catenin proteins in imatinib resistance of chronic myeloid leukemia Open
We show for the first time that Akirin-2 can be a novel biomarker in imatinib resistance. Targeting Akirin-2, NFκB and β-catenin genes may provide an opportunity to overcome imatinib resistance in CML.
View article: Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations
Integration of in vitro and in silico perspectives to explain chemical characterization, biological potential and anticancer effects of Hypericum salsugineum: A pharmacologically active source for functional drug formulations Open
The genus Hypericum is one of the most popular genera in both traditional medicine and scientific platform. This study is designed to provide conceptual insights on the biological potential and chemical characterization of H. salsugineum, …
View article: Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans
Evaluation of the lifespan extension effects of several Turkish medicinal plants in Caenorhabditis elegans Open
Research on longevity is important to both prolong lifespan and support healthy aging. Natural products are widely being utilized and used as new resources for drug molecules. Caenorhabditis elegans is an advantageous organism for longevit…
View article: Evaluation of the lifespan extension effects of several Turkish medicinal plants in <i>Caenorhabditis elegans</i>
Evaluation of the lifespan extension effects of several Turkish medicinal plants in <i>Caenorhabditis elegans</i> Open
&nbsp; Research on longevity is important to both prolong lifespan and support healthy aging. Natural products are widely being utilized and used as new resources for drug molecules. Caenorhabditis elegans is an advantageous organism f…
View article: Evaluation of anti-proliferative and cytotoxic effects of chlorogenic acid on breast cancer cell lines by real-time, label-free and high-throughput screening
Evaluation of anti-proliferative and cytotoxic effects of chlorogenic acid on breast cancer cell lines by real-time, label-free and high-throughput screening Open
Chlorogenic acid (CGA) is a major polyphenol in primary human diet, displaying a wide range of biological activities such as anti-oxidant, anti-inflammatory and anti-cancer effects.Several studies reported the chemopreventive effects of CG…
View article: Evaluation of Anti-Proliferative and Cytotoxic Properties of Chlorogenic Acid against Breast Cancer Cell Lines by Real Time Monitoring
Evaluation of Anti-Proliferative and Cytotoxic Properties of Chlorogenic Acid against Breast Cancer Cell Lines by Real Time Monitoring Open
Chlorogenic acid (CGA) is a major polyphenol in primary human diet, which has a wide range of biological activities including anti-oxidant, anti-inflammatory and anti-cancer effects. Several studies showed CGA’s chemopreventive roles on di…
View article: Traditionally Used Lathyrus Species: Phytochemical Composition, Antioxidant Activity, Enzyme Inhibitory Properties, Cytotoxic Effects, and in silico Studies of L. czeczottianus and L. nissolia
Traditionally Used Lathyrus Species: Phytochemical Composition, Antioxidant Activity, Enzyme Inhibitory Properties, Cytotoxic Effects, and in silico Studies of L. czeczottianus and L. nissolia Open
Members of the genus Lathyrus are used as food and as traditional medicines. In order to find new sources of biologically-active compounds, chemical and biological profiles of two Lathyrus species (L. czeczottianus and L. nissolia) were in…
View article: Identification of differentially expressed microRNAs during lipotoxic endoplasmic reticulum stress in RAW264.7 macrophages / RAW264.7 makrofajlarında lipotoksik endoplazmik retikulum stres sürecinde ifadesi değişen mikroRNAların tanımlanması
Identification of differentially expressed microRNAs during lipotoxic endoplasmic reticulum stress in RAW264.7 macrophages / RAW264.7 makrofajlarında lipotoksik endoplazmik retikulum stres sürecinde ifadesi değişen mikroRNAların tanımlanması Open
Objective: Increased fatty acids in the circulation and their accumulation in non-adipose tissues play a significant role in the development of obesity related metabolic and inflammatory disorders such as insulin resistance, diabetes and a…
View article: Analysis of global microRNAome profiles of Caenorhabditis elegans oocytes and early embryos
Analysis of global microRNAome profiles of Caenorhabditis elegans oocytes and early embryos Open
One of the most complex cell transformations in biology is the remodeling of a fertilized oocyte into a totipotent zygote. There is no transcription during this event, and therefore mRNAs and proteins accumulated in the oocyte during oogen…
View article: Effects of radiation doses from different dental imaging modalities on cell-implant interaction: A comparison with cell culture study
Effects of radiation doses from different dental imaging modalities on cell-implant interaction: A comparison with cell culture study Open
Objectives: The effect of radiation after exposing with dental imaging devices on cell-implant material interaction has not been adequately studied. The aim of this study is to determine the effects of radiation by measuring proliferation …
View article: RNA Interference and Current Clinical Applications: Review
RNA Interference and Current Clinical Applications: Review Open
Modern biyolojinin teknolojik devrimlerden birisi olan RNA interferans (RNAi), hem ökaryotlarda gen fonksiyonlarının analizinde önemli bir araç haline gelmiş hem de terapötik olarak gen susturulması çalışmalarında umut vaad ederek sıkça ku…