Åsa Hellberg
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View article: Noninvasive fetal antigen genotyping: Results from a survey on the status of clinical implementation
Noninvasive fetal antigen genotyping: Results from a survey on the status of clinical implementation Open
Background and Objectives Noninvasive fetal antigen genotyping can assist the management of immunized pregnant women, and fetal RHD genotyping can be used as a screening assay to guide restricted use of Rh prophylaxis. Based on a survey, w…
View article: Single-exon fetal RHD genotyping: a 31-month follow up in the obstetric population of Western Sweden.
Single-exon fetal RHD genotyping: a 31-month follow up in the obstetric population of Western Sweden. Open
The single-exon approach for fetal RHD screening early in pregnancy is an appropriate choice in the population of Western Sweden, with a very low frequency of inconclusive results caused by the presence of maternal RHD gene variants. Due t…
View article: A Bioinformatically Initiated Approach to Evaluate GATA1 Regulatory Regions in Samples with Weak D, Del, or D– Phenotypes Despite Normal <i>RHD</i> Exons
A Bioinformatically Initiated Approach to Evaluate GATA1 Regulatory Regions in Samples with Weak D, Del, or D– Phenotypes Despite Normal <i>RHD</i> Exons Open
Introduction: With over 360 blood group antigens in systems recognized, there are antigens, such as RhD, which demonstrate a quantitative reduction in antigen expression due to nucleotide variants in the non-coding region of the gene that …
View article: Truncated glycosyltransferase coding regions in novel<scp>ABO</scp>alleles give rise to weak A or B blood group expression and discrepant typing results
Truncated glycosyltransferase coding regions in novel<span>ABO</span>alleles give rise to weak A or B blood group expression and discrepant typing results Open
Background Correct ABO blood‐group matching between donor and patient is crucial for safe transfusions. We investigated the underlying reason causing inconclusive ABO serology in samples referred to our laboratory. Study Design and Methods…
View article: A novel nonsense variant in <scp><i>RHAG</i></scp> underlies a Nordic Rh<sub>null</sub> phenotype
A novel nonsense variant in <span><i>RHAG</i></span> underlies a Nordic Rh<sub>null</sub> phenotype Open
Background and Objectives The extremely rare Rh null phenotype is characterized by the absence of all Rh antigens on erythrocytes. It is divided into the regulator and amorph types based on the underlying genetic background. The more commo…
View article: A new missense variant in exon 7 of the <scp><i>ABO</i></scp> gene, c.<scp>662G</scp>>A, in a family with B<sub>w</sub> phenotype
A new missense variant in exon 7 of the <span><i>ABO</i></span> gene, c.<span>662G</span>>A, in a family with B<sub>w</sub> phenotype Open
1 BACKGROUNDWeak expression of ABO antigens is encountered in the clinical laboratory occasionally, and subgroups of A are more commonly observed in Europeans than subgroups of B. To date, weakly expressing B variant phenotypes have been a…
View article: International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems
International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems Open
Background and Objectives Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP bu…
View article: Noninvasive Prenatal Testing in Immunohematology—Clinical, Technical and Ethical Considerations
Noninvasive Prenatal Testing in Immunohematology—Clinical, Technical and Ethical Considerations Open
Hemolytic disease of the fetus and newborn (HDFN), as well as fetal and neonatal alloimmune thrombocytopenia (FNAIT), represent two important disease entities that are caused by maternal IgG antibodies directed against nonmaternally inheri…
View article: Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System
Glycoproteomic and Phenotypic Elucidation of B4GALNT2 Expression Variants in the SID Histo-Blood Group System Open
The Sda histo-blood group antigen (GalNAcβ1-4(NeuAcα2-3)Galβ-R) is implicated in various infections and constitutes a potential biomarker for colon cancer. Sd(a−) individuals (2–4% of Europeans) may produce anti-Sda, which can lead to inco…
View article: Recommendation for validation and quality assurance of non‐invasive prenatal testing for foetal blood groups and implications for <scp>IVD</scp> risk classification according to <scp>EU</scp> regulations
Recommendation for validation and quality assurance of non‐invasive prenatal testing for foetal blood groups and implications for <span>IVD</span> risk classification according to <span>EU</span> regulations Open
Background and Objectives Non‐invasive assays for predicting foetal blood group status in pregnancy serve as valuable clinical tools in the management of pregnancies at risk of detrimental consequences due to blood group antigen incompatib…
View article: A novel <scp><i>ABO</i></scp> allele with a 21‐bp duplication identified in two unrelated European individuals with weak A expression
A novel <span><i>ABO</i></span> allele with a 21‐bp duplication identified in two unrelated European individuals with weak A expression Open
Objectives To carry out genetic and serological analyses of a Swiss blood donor and a Danish patient carrying an aberrant ABO phenotype with weak A expression. Background ABO is the most clinically important blood group system but also one…
View article: The P1PK blood group system: revisited and resolved
The P1PK blood group system: revisited and resolved Open
This update on the P1PK blood group system (Hellberg Å, Westman JS, Thuresson B, Olsson ML. P1PK: the blood group system that changed its name and expanded. Immunohematology 2013;29:25–33) provides recent findings concerning the P1PK blood…
View article: Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT
Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT Open
Key Points The intronic A4GALT SNP rs5751348 defines a hematopoietic transcription factor–binding site present in P1 but not P2 blood group alleles. RUNX1 selectively binds to this regulatory site in P1 alleles; small interfering RNA knock…
View article: ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis
ABO zygosity, but not secretor or Fc receptor status, is a significant risk factor for IVIG-associated hemolysis Open
TO THE EDITOR:
Although frequently effective[1][1],[2][2] and usually benign, high-dose (2 g/kg) intravenous immunoglobulin (IVIG) therapy can result in marked red blood cell (RBC) hemolysis, which in some cases is life threatening in sev…
View article: A novel <i>RHCE*02</i> allele, containing the single‐nucleotide change c.460A>G, encodes weakened expression of C and e antigens
A novel <i>RHCE*02</i> allele, containing the single‐nucleotide change c.460A>G, encodes weakened expression of C and e antigens Open
We report a novel RHCE*02 allele in a Swedish blood donor that is characterized by the change c.460A>G (Arg154Gly). The blood donor's red blood cells showed variable reactivity with different monoclonal anti‐C and anti‐e and antigen streng…