Asa Kessler
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View article: Apoptotic Cell–Based Therapy for the Modification of the Inflammatory Response to Hemorrhagic Shock
Apoptotic Cell–Based Therapy for the Modification of the Inflammatory Response to Hemorrhagic Shock Open
Introduction Many trauma patients die from hemorrhagic shock in the military and civilian settings. Although two-thirds of hemorrhagic shock victims die of reasons other than exsanguination, such as the consequent cytokine storm, anti-infl…
View article: Direct Oral Anticoagulants in Special Patient Populations
Direct Oral Anticoagulants in Special Patient Populations Open
Anticoagulants are a cornerstone of treatment in atrial fibrillation. Nowadays, direct oral anticoagulants (DOACs) are extensively used for this condition in developed countries. However, DOAC treatment may be inappropriate in certain pati…
View article: Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro, and safety for application to COVID-19 patients in a pilot clinical study
Tumor Treating Fields (TTFields) demonstrate antiviral functions in vitro, and safety for application to COVID-19 patients in a pilot clinical study Open
Coronaviruses are the causative agents of several recent outbreaks, including the COVID-19 pandemic. One therapeutic approach is blocking viral binding to the host receptor. As binding largely depends on electrostatic interactions, we hypo…
View article: Serum Levels of Adropin Improve the Predictability of MELD and Child-Pugh Score in Cirrhosis: Results of Proof-of-Concept Clinical Trial
Serum Levels of Adropin Improve the Predictability of MELD and Child-Pugh Score in Cirrhosis: Results of Proof-of-Concept Clinical Trial Open
Adropin is a peptide that was suggested to have a role in cirrhosis. The present study aimed to determine the ability to use serum adropin levels to improve their prediction accuracy as an adjunct to the current scores. In a single-center,…
View article: A Randomized Controlled Study Assessing Convalescent Immunoglobulins vs Convalescent Plasma for Hospitalized Patients With Coronavirus 2019
A Randomized Controlled Study Assessing Convalescent Immunoglobulins vs Convalescent Plasma for Hospitalized Patients With Coronavirus 2019 Open
Background It is unknown whether convalescent immunoglobulins (cIgGs) are better than convalescent plasma (CP) for patients with coronavirus 2019 (COVID-19). Methods In this randomized controlled trial, we assigned high risk COVID-19 patie…
View article: Novel targeted inhibition of the IL-5 axis for drug reaction with eosinophilia and systemic symptoms syndrome
Novel targeted inhibition of the IL-5 axis for drug reaction with eosinophilia and systemic symptoms syndrome Open
Background The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome represents a severe hypersensitivity reaction. Up-to-date treatment is based on withdrawal of medication, supportive care, and immunosuppression using hi…
View article: Codivir suppresses SARS-Cov-2 viral replication and stabilizes clinical outcome: In vitro and Phase I clinical trial results
Codivir suppresses SARS-Cov-2 viral replication and stabilizes clinical outcome: In vitro and Phase I clinical trial results Open
BACKGROUND: Treatment of severe acute respiratory distress syndrome coronavirus 2 (SARSCoV-2) remains a significant challenge in the face of increased worldwide morbidity and mortality. The acute illness caused by SARS-CoV-2 is initiated b…
View article: Successful Treatment of Near Fatal Cardiogenic Shock Following Toxic Mushroom Ingestion
Successful Treatment of Near Fatal Cardiogenic Shock Following Toxic Mushroom Ingestion Open
Myocardial injury and hemodynamic compromise following toxic mushroom ingestion is rare. Here we present a case of cardiogenic shock after Amanita proxima ingestion, presenting with severe hemodynamic collapse necessitating mechanical circ…
View article: A Unique Case of Myositis
A Unique Case of Myositis Open
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare systemic small-vessel disease, with heterogeneous clinical manifestations. While arthralgia and myalgia are common in the disease course, frank myositis is e…
View article: Management of heart failure with reduced ejection fraction: challenges in patients with atrial fibrillation, renal disease and in the elderly
Management of heart failure with reduced ejection fraction: challenges in patients with atrial fibrillation, renal disease and in the elderly Open
Heart failure with reduced ejection fraction (HFrEF) is an increasing global pandemic affecting more than 30 million individuals worldwide. Importantly, HFrEF is frequently accompanied by the presence of cardiac and non-cardiac comorbiditi…
View article: From TTP to Glomerulonephritis: A Lifetime of Lupus
From TTP to Glomerulonephritis: A Lifetime of Lupus Open
We report the case of a 56-year-old male patient, who over two decades, sequentially presented with a combination of clinical manifestations. These included thrombotic thrombocytopenic purpura (TTP), right leg deep vein thrombosis (DVT), a…
View article: A unique COVID-19 case
A unique COVID-19 case Open
We present the case of a patient with granulomatosis with polyangiitis (GPA) treated with rituximab, who was diagnosed with coronavirus disease 2019 (COVID-19). Following an index hospitalization with apparent resolution of the infection, …
View article: Antibody Response to Severe Acute Respiratory Syndrome‐ Corona Virus 2, Diagnostic and Therapeutic Implications
Antibody Response to Severe Acute Respiratory Syndrome‐ Corona Virus 2, Diagnostic and Therapeutic Implications Open
The immune response against severe acute respiratory syndrome‐corona virus 2 (SARS‐CoV‐2) is comprised of both cellular and humoral arms. While current diagnostic methods are mainly based on polymerase chain reaction, they suffer from inse…
View article: Clinical Correlates of Early IgG Response in Patients with Mild COVID-19
Clinical Correlates of Early IgG Response in Patients with Mild COVID-19 Open
Background: We determined the temporal pattern of early SARS-CoV-2 IgG response in patients with mild COVID-19, and sought to identify predictive clinical and laboratory features. Methods: Serum samples were prospectively obtained from 11…
View article: Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents
Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming resistance to antiviral agents Open
The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus 2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a pressing global need for effective antiviral therapies agains…