Explanipedia

Prevalence and Predictors of Opioid Use Before Spine Surgery: A Multicenter, Cross‐Sectional Observational Study Open

Shania Liu, Jennifer Stevens, C. Lang Tran, Ashleigh Collins, Jed Duff , et al. · 2025

Spine surgery is performed on 45 000 Australians annually, and opioids are frequently used for pain management before spine surgery, although concerns about their effectiveness and harms persist. Evidence suggests preoperative opioid use i…

Quality indicators for opioid stewardship interventions in hospital inpatient and emergency departments: a systematic review Open

Chelsea Dutkiewicz, Katelyn Jauregui, Shania Liu, Racha Dabliz, Asad E. Patanwala , et al. · 2025

A systematic review was conducted to identify existing quality indicators for opioid stewardship in hospital inpatient and emergency departments. Five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Scopus) and grey literature were search…

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings Open

Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala · 2025

Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these obj…

Tocilizumab, sarilumab and anakinra in critically ill patients with COVID-19: a randomised, controlled, open-label, adaptive platform trial Open

Lennie Derde, Anthony Gordon, Paul Mouncey, Farah Al-Beidh, Kathy Rowan , et al. · 2025

Introduction Tocilizumab improves outcomes in critically ill patients with COVID-19. Whether other immune-modulator strategies are equally effective or better is unknown. Methods We investigated treatment with tocilizumab, sarilumab, anaki…

Implementing CYP2C19-guided clopidogrel therapy: a scoping review of pharmacogenomic testing services Open

Trishna Patel, Eman Wehbe, Stephen Hughes, Asad E. Patanwala, Leonard Kritharides , et al. · 2025

Comparative Effectiveness of Different Opioid Regimens, in Daily Dose or Treatment Duration, Prescribed at Surgical Discharge: a Systematic Review and Meta-Analysis Open

Masoud Jamshidi, Caitlin Jones, Aili Langford, Asad E. Patanwala, Chang Liu , et al. · 2025

A National Retrospective Cohort Study Comparing the Effects of Cefepime Versus Piperacillin-Tazobactam on the Development of Severe Acute Kidney Injury in Patients With Septic Shock Open

Asad E. Patanwala, David E. Nix, Thomas Hills, Brian L. Erstad · 2024

Background Cefepime and piperacillin-tazobactam are commonly used broad-spectrum antibiotics used to treat patients with potential gram-negative bacterial sepsis. Piperacillin-tazobactam has been shown to be associated with acute kidney in…

Clinicians’ perspective of the opioid analgesic stewardship in acute pain clinical care standard Open

Chelsea Dutkiewicz, Shania Liu, Asad E. Patanwala, Andrew J. McLachlan, Jennifer Stevens , et al. · 2024

Finding individualised treatment in obese needing enoxaparin (FIT ONE): a multicentre study of therapeutic enoxaparin and the role of anti-factor Xa monitoring Open

Marcelle Appay, Justine Lai, Justine Hay, Connie Calvisi, Geoffrey Wills , et al. · 2024

Using <i>personal health records</i> for medication continuity during transition of care: An observational study Open

M. J. O. Francis, Peter J. Francis, Meredith Makeham, Melissa Baysari, Asad E. Patanwala , et al. · 2024

Background: National Personal Health Records (PHRs) have been proposed to improve the transfer of medication-related information during transition of care. Objective: To evaluate the concordance between the medications captured in the Aust…

A pilot multicentre randomised clinical trial to determine the effect of a pharmacist‐partnered opioid tapering intervention before total hip or knee arthroplasty Open

Shania Liu, Asad E. Patanwala, Jennifer Stevens, Jonathan Penm, Justine Naylor · 2024

Summary Background Opioid analgesic use before total hip or knee arthroplasty has been associated with worse postoperative outcomes. This pilot study aimed to examine the feasibility of a telehealth‐based pharmacist‐partnered opioid taperi…

Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses Open

Zhiying Cao, Kaiyue Han, Hanting Lu, Sandalika Illangamudalige, Christina Abdel Shaheed , et al. · 2024

Low-to-moderate quality evidence supports the oral use of some paracetamol plus NSAID combinations for short-term pain relief with no increased risk of harm for low back pain and osteoarthritis compared to its non-paracetamol monotherapy c…

Therapeutic Drug Monitoring and Biomarkers; towards Better Dosing of Antimicrobial Therapy Open

Eman Wehbe, Asad E. Patanwala, Christine Y. Lu, Hannah Yejin Kim, Sophie L. Stocker , et al. · 2024

Due to variability in pharmacokinetics and pharmacodynamics, clinical outcomes of antimicrobial drug therapy vary between patients. As such, personalised medication management, considering both pharmacokinetics and pharmacodynamics, is a g…

Low rate of surgical site infections after liver transplantation: A 5‐year retrospective cohort study Open

Taryar Tun, Tina Marinelli, Ken Liu, Simone I. Strasser, Michael Crawford , et al. · 2024

Background Surgical site infection (SSI) after liver transplant (LT) is common, but no studies have been conducted in Australia. The purpose of this study was to determine the proportion of patients who developed an SSI post‐LT in Australi…

Does preoperative opioid use predict outcomes to 6 months following primary unilateral knee or hip arthroplasty for osteoarthritis? A data-linked retrospective study Open

Furkan Genel, Ian A. Harris, Natalie Pavlovic, Adriane M. Lewin, Rajat Mittal , et al. · 2024

Prevalence and predictors of opioid use before orthopaedic surgery in an Australian setting: a multicentre, cross-sectional, observational study Open

Shania Liu, Jennifer Stevens, Ashleigh Collins, Jedd Duff, Joanna Sutherland , et al. · 2024

Aim: This study aimed to examine the prevalence of any opioid use before elective orthopaedic surgery with a focus on regional and rural hospitals in New South Wales, Australia. Methods: This was a cross-sectional, observational study of p…

Factors Influencing Health Care Professionals' Perceptions of Frequent Drug–Drug Interaction Alerts Open

Yasmine Biady, Teresa Lee, Lily Pham, Asad E. Patanwala, Simon Poon , et al. · 2024

Background Drug–drug interactions (DDIs) remain a highly prevalent issue for patients in both community and hospital settings. Electronic medication management systems have implemented DDI alerts to mitigate DDI-related harm from occurring…

Patients' experiences of subacute pain management following total hip or knee arthroplasty: A qualitative study Open

Shania Liu, Hadi A. Almansour, Lily Pham, Furkan Genel, Ian A. Harris , et al. · 2023

Background Total hip and knee arthroplasties are common surgeries performed worldwide, but the management of pain during the subacute period (defined as hospital discharge to 3 months postoperatively) is poorly understood. This study aimed…

Prevalence and predictors of long-term opioid use following orthopaedic surgery in an Australian setting: A multicentre, prospective cohort study Open

Shania Liu, Jennifer Stevens, Ashleigh E Collins, Jed Duff, Joanna Sutherland , et al. · 2023

Opioid analgesics prescribed for the management of acute pain following orthopaedic surgery may lead to unintended long-term opioid use and associated patient harms. This study aimed to examine the prevalence of opioid use at 90 days after…

International pharmacy survey of peripheral vasopressor infusions in critical care (INFUSE) Open

Arwa Abu Sardaneh, Jonathan Penm, Matthew Oliver, David Gattas, Andrew J. McLachlan , et al. · 2023

There is variability in clinical practice regarding PVI administration in critically ill adult patients dependent on drug availability and local institutional recommendations.

Risks and benefits of oral modified‐release compared with oral immediate‐release opioid use after surgery: a systematic review and meta‐analysis Open

Shania Liu, Ali Athar, Duc Trong Quach, Asad E. Patanwala, Justine Naylor , et al. · 2023

Summary Prescription of modified‐release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta‐analysis aimed to e…

Correction: Obtaining medication histories via telepharmacy: an observational study Open

M. J. O. Francis, Peter J. Francis, Asad E. Patanwala, Jonathan Penm · 2023

Impact of modified‐release opioid use on clinical outcomes following total hip and knee arthroplasty: a propensity score‐matched cohort study Open

Shania Liu, Asad E. Patanwala, Justine Naylor, Nicholas Levy, Roger Knaggs , et al. · 2023

Summary Modified‐release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The p…

An update on drug-drug interactions for care of the acutely ill in the era of COVID-19 Open

Asad E. Patanwala, Nynke G L Jager, John Radosevich, Roger J. M. Brüggemann · 2023

Purpose To provide key pharmacological concepts underlying drug-drug interactions (DDIs), a decision-making framework, and a list of DDIs that should be considered in the context of contemporary acutely ill patients with COVID-19. Summary …

Obtaining medication histories via telepharmacy: an observational study Open

M. J. O. Francis, Peter J. Francis, Asad E. Patanwala, Jonathan Penm · 2023

Telepharmacy represents a reliable and time-efficient alternative to in-person BPMHs.

Continuation of therapeutic dose heparin for critically ill patients with COVID-19 Open

Charlotte Bradbury, Patrick R. Lawler, Bryan J. McVerry, Ryan Zarychanski, Farah Al-Beidh , et al. · 2023

Student-led medication histories in hospitals during the COVID-19 pandemic: Analysis of student and preceptor feedback Open

Linda Do, Carl R. Schneider, Jonathan Penm, Asad E. Patanwala, Rosemary Burke , et al. · 2023

Issue Information Open

M. Wicks, Elizabeth Barr, Louise Maple‐Brown, Sujita W. Narayan, Fady Gad , et al. · 2023

Changes in medication regimen complexity index following medication-related hospital admissions: A retrospective single-centre study Open

Isabelle Gillooly, Edwin C.K. Tan, Ilsa R. Wojt, Asad E. Patanwala, Rose Cairns · 2023

There was a decrease in MRCI following medication-related hospitalisation. Targeted medication reviews for high-risk patients (e.g., those with medication-related hospitalisations) could further reduce the burden of medication complexity f…

Effect of a Pharmacist-Led Opioid Tapering Intervention Before Total Hip or Knee Arthroplasty.The Responsible Opioid Use for Hip and Knee ArthropLasTy (OpioidHALT) Randomised Clinical Pilot Trial Open

Shania Liu, Asad E. Patanwala, Jennifer Stevens, Furkan Genel, Sam Adie , et al. · 2023

Asad E. Patanwala YOU? Author Swipe