Asem Shalaby
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View article: Correlation of HER2 Expression in Gastric Carcinoma with Clinicopathological Parameters in the Omani Population
Correlation of HER2 Expression in Gastric Carcinoma with Clinicopathological Parameters in the Omani Population Open
This retrospective study was conducted to determine the relation between human epidermal growth factor receptor 2 (HER2) expression and the clinicopathological and prognostic characteristics of gastric cancer (GC) patients treated at the D…
View article: A Systematic Review of Diagnostic Performance of Circulating MicroRNAs in Colorectal Cancer Detection with a Focus on Early-Onset Colorectal Cancer
A Systematic Review of Diagnostic Performance of Circulating MicroRNAs in Colorectal Cancer Detection with a Focus on Early-Onset Colorectal Cancer Open
The rising incidence and mortality of early-onset colorectal cancer (EOCRC) emphasize the urgent need for effective non-invasive screening. Circulating microRNAs (miRNAs) have emerged as promising biomarkers for cancer detection. This syst…
View article: Correlation of PD-L1 expression with different clinico-pathological and immunohistochemical features of ovarian surface epithelial tumors
Correlation of PD-L1 expression with different clinico-pathological and immunohistochemical features of ovarian surface epithelial tumors Open
Background Primary carcinoma of the ovary (OCs) are responsible for a significant number of deaths related to cancer, and have the highest rate of death related to cancers of the female reproductive organs. Programmed cell death 1 (PD1) pr…
View article: Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman
Analysis of Immunohistochemical Expression of BRAF (V600E) Mutation in Serrated Colorectal Polyps: A Study from Tertiary Hospital in Oman Open
Serrated polyps are now well known for their potential to develop CRC. Immunohistochemistry is an easy and reproducible way to detect BRAF (V600E) mutation. Our study showed there is high prevalence (64.3%) of BRAF mutation in serrated pol…
View article: Evaluation of the Expression EGFR, HER2/NEU and the End Effector ERK of the RAS/RAF/MAP Kinase Pathway in Prostatic Adenocarcinoma for a Possible Role as New Target Therapy
Evaluation of the Expression EGFR, HER2/NEU and the End Effector ERK of the RAS/RAF/MAP Kinase Pathway in Prostatic Adenocarcinoma for a Possible Role as New Target Therapy Open
EGFR and HER2/neu may play a limited role in prostatic adenocarcinoma as they showed positive expression in a limited number of the examined tissues specifically HER2neu. The expression of non-phosphorylated ERK (mostly weak to moderate) a…
View article: Health-Related Quality of Life of Omani Adult Patients with Sickle Cell Disease at the Sultan Qaboos University Hospital
Health-Related Quality of Life of Omani Adult Patients with Sickle Cell Disease at the Sultan Qaboos University Hospital Open
Erdheim-Chester disease (ECD) is a rare form of non-Langerhans cell histiocytosis with unknown aetiology. It is recently recognised to be neoplastic with genetic mutations affecting the mitogen-activating protein kinase pathway. We report …
View article: Immunohistochemical study of mismatch repair and programmed death ligand-1 protein expression in prostatic acinar adenocarcinoma in correlation with patient clinicopathological parameters
Immunohistochemical study of mismatch repair and programmed death ligand-1 protein expression in prostatic acinar adenocarcinoma in correlation with patient clinicopathological parameters Open
Background Castrate-resistant prostate cancer (CRPC) is the main challenge among prostate cancer patients; most are metastatic and eventually resist any treatment. No cure yet exists for them. Aim Investigate the immunohistochemical expres…
View article: Association between the Expression Patterns of Hepatitis B Surface Antigen and Hepatitis B Core Antigen with Clinicopathological Parameters and Antiviral Therapy in Liver Biopsies Obtained from Chronically Infected Hepatitis B Positive Omani Patients
Association between the Expression Patterns of Hepatitis B Surface Antigen and Hepatitis B Core Antigen with Clinicopathological Parameters and Antiviral Therapy in Liver Biopsies Obtained from Chronically Infected Hepatitis B Positive Omani Patients Open
Background: Hepatitis B virus (HBV) infection is considered a major global health problem. The main objectives of the current study is to determine the patterns of expression of the hepatitis B surface antigen (HBsAg) and HBV core antigen …
View article: Influence of Different Conditioning Protocols on Bond Strength to Glass Ceramic
Influence of Different Conditioning Protocols on Bond Strength to Glass Ceramic Open
Sixteen glass ceramic blocks (IPS e.max CAD/CAM) were fabricated by a CAD/CAM machine withdimensions (6mm × 11mm x 13mm) and divided into 4 groups (n=4), according to surface treatments: (G1)Hydrofluoric acid (HF) etching and silane applic…
View article: An Immunohistochemical Study for Mammalian Target of Rapamycin Signaling Pathway Including Interacting PTEN in Prostatic Acinar Adenocarcinoma and Correlation with the Patient Clinicopathological Parameters
An Immunohistochemical Study for Mammalian Target of Rapamycin Signaling Pathway Including Interacting PTEN in Prostatic Acinar Adenocarcinoma and Correlation with the Patient Clinicopathological Parameters Open
Background: The activation of AKT-mTOR-PTEN pathway may promote prostate cancer progression and affects response to targeted therapies. The full extent of this activation remains to be determined. Our aim: was to assess the expression of i…
View article: Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma
Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma Open
A panel of immunohistochemical markers (PD-L1, MLH1, MSH2 and p53) could help to predict the prognosis and plan the treatment of patients with EC. MMR deficiency seems to be a good predictor for PD-L1 status, and therefore the response to …
View article: Prevention of post-surgical adhesion bands by local administration of frankincense n-hexane extract
Prevention of post-surgical adhesion bands by local administration of frankincense n-hexane extract Open
The study reported the potential of FHE as an ointment for the prevention of adhesion bands.
View article: Mobile Phone Electromagnetic Fields Affecting the Hepatocytes in the White Leghorn Chicken Embryo: An Ultrastructural Study
Mobile Phone Electromagnetic Fields Affecting the Hepatocytes in the White Leghorn Chicken Embryo: An Ultrastructural Study Open
Introduction Smart phones have added a new dimension into our lives. We are more preoccupied with our mobiles than talking to persons seated next to us. Parents give mobiles to their two-year olds to play with instead of toys. Before trave…
View article: The Value of Programmed Death Ligand 1 Expression in Cancer Patients Treated with Neoadjuvant Chemotherapy
The Value of Programmed Death Ligand 1 Expression in Cancer Patients Treated with Neoadjuvant Chemotherapy Open
Programmed death ligand 1 (PD-L1) is an inhibitory molecule expressed by cancer cells to supress T-cell activity and escape anti-tumour immunity. The role of PD-L1 in cancer has been studied extensively as it is considered an important imm…
View article: THE PREVALENCE OF DYSPLASIA IN COLORECTAL SERRATED/HYPERPLASTIC POLYPS IN OMANI POPULATION
THE PREVALENCE OF DYSPLASIA IN COLORECTAL SERRATED/HYPERPLASTIC POLYPS IN OMANI POPULATION Open
Purpose: Serrated/hyperplastic polyps (SPs) are characterised histologically by sawtooth architecture. Historically, these polyps were considered benign, without malignant potential and thus clinically unimportant. At present, the WHO defi…
View article: Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats
Effect of levosimendan, a calcium sensitizer, on cisplatin-induced nephrotoxicity in rats Open
We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second groups received normal saline (control) and intraperitoneal (i.p.) cisplatin (6 mg/kg) o…
View article: Estimation of Serum Interleukin-18 and Hs-CRP in Chronic Hepatitis C Infected Patients at Assuit Governorate, Egypt
Estimation of Serum Interleukin-18 and Hs-CRP in Chronic Hepatitis C Infected Patients at Assuit Governorate, Egypt Open
Hepatitis C virus (HCV) infection is a global health problem.Egypt has the highest prevalence of hepatitis C virus (HCV) in the world.as a critical multipotent inducer of innate and acquired immune responses.This study aimed to estimate IL…
View article: Mobile Phone Electromagnetic Waves Causing Fatty Change in the Hepatocytes of the Developing Chick Embryo: Are Smart Phones too Close for Comfort?
Mobile Phone Electromagnetic Waves Causing Fatty Change in the Hepatocytes of the Developing Chick Embryo: Are Smart Phones too Close for Comfort? Open
Introduction Smart phones have added a new dimension into our lives. We are busier with our mobile than talking to the person sitting next to us. Parents give their mobiles to their two-year old to play with instead of toys. Before traveli…
View article: The In Vivo Effects of Adenine-Induced Chronic Kidney Disease on Some Renal and Hepatic Function and CYP450 Metabolizing Enzymes
The In Vivo Effects of Adenine-Induced Chronic Kidney Disease on Some Renal and Hepatic Function and CYP450 Metabolizing Enzymes Open
Adenine-induced model of chronic kidney disease (CKD) is a widely used model especially in studies testing novel nephroprotective agents. We investigated the effects of adenine-induced CKD in rats on the activities of some xenobiotic metab…
View article: Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice
Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive System in Male Mice Open
There is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term expos…
View article: Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index
Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index Open
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer in which calpain system plays an important role in its cellular processes including apoptosis and proliferation. Although such roles have been assessed in tumor pa…