Asha Thomas
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View article: HSPiP and quality by design-assisted optimized analytical method validation for linagliptin and dapagliflozin using HPTLC
HSPiP and quality by design-assisted optimized analytical method validation for linagliptin and dapagliflozin using HPTLC Open
A simultaneous estimation of linagliptin and dapagliflozin from a combination product is still challenging in terms of sensitivity, analytical cost, efficiency, time, simplicity, accuracy, and reproducibility. To circumvent the current iss…
View article: MON-469 From Fatigue to Crisis: A Case of Primary Adrenal Insufficiency Triggered by Levothyroxine
MON-469 From Fatigue to Crisis: A Case of Primary Adrenal Insufficiency Triggered by Levothyroxine Open
Disclosure: H.C. Davuluri: None. A. Thomas: None. Introduction: Adrenal insufficiency can present in a dramatic manner with a myriad of initiating events. Case: A 20-year-old woman with history of Arnold-Chiari type I malformation presente…
View article: Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i>
Homeostatic Influence of Fig4 Outside of the Fab1‐Vac14‐Fig4 Complex in <i>Saccharomyces cerevisiae</i> Open
The lipid phosphatase Fig4 is conserved in all eukaryotes and is associated with human neurological diseases for which there are currently no specific therapies. Fig4 functions in both the production and turnover of its lipid substrate, PI…
View article: Development of Voriconazole Proliposome Based Dry Powder for Inhalation: A Design of Experiment Approach
Development of Voriconazole Proliposome Based Dry Powder for Inhalation: A Design of Experiment Approach Open
The present investigation aimed to formulate and optimize sustained release proliposome dry powder for inhalation of Voriconazole (VZ) and its in vitro and in vivo evaluation. The proliposome-based dry powder for inhalation was formulated …
View article: EVALUATING AND QUANTIFYING THE BIOACTIVE POTENTIAL OF HYGROPHILA SPINOSA
EVALUATING AND QUANTIFYING THE BIOACTIVE POTENTIAL OF HYGROPHILA SPINOSA Open
Objectives: The quantification of Quercetin (QR) and Lupeol (LU) in the seed extract of Hygrophila spinosa has been accomplished using a highly efficient, rapid, and precise high-performance thin-layer chromatographic (HPTLC) method. Metho…
View article: Flash chromatographic separation and diabetic wound healing study of Hemigraphis alternata leaves extract
Flash chromatographic separation and diabetic wound healing study of Hemigraphis alternata leaves extract Open
Diabetes, a multifaceted disorder associated with delayed wound healing due to persistent hyperglycaemia and related comorbidities, which increases morbidity, mortality and worsens quality of life. Hemigraphis alternata possess wound heali…
View article: 2024 American College of Rheumatology (<scp>ACR</scp>) Guideline for the Screening, Treatment, and Management of Lupus Nephritis
2024 American College of Rheumatology (<span>ACR</span>) Guideline for the Screening, Treatment, and Management of Lupus Nephritis Open
Objective The objective is to provide evidence‐based and expert guidance for the screening, treatment, and management of lupus nephritis. Methods The Core Team developed clinical questions for screening, treatment, and management of lupus …
View article: An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats
An in-vivo herb-drug interaction study of IME-9 and glimepiride in nicotinamide-STZ-induced diabetic rats Open
Background: Currently, herbs are frequently employed for medicinal or dietary purposes alongside both prescribed and over-the-counter medications. Despite being perceived as natural and benign, herbs carry the potential to interact with me…
View article: Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders
Correlation of non-alcoholic fatty liver disease and neurodegenerative disorders Open
Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodeg…
View article: Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold
Fig4 confers tolerance to rapamycin in a Ste20-dependent manner independent of the Vac14 scaffold Open
The lipid phosphatase Fig4 modulates the production and turnover of the signaling lipid PI3,5P2 through participation in a complex with its opposing kinase, Fab1, and the scaffold protein Vac14. Fig4 point mutations are associated with neu…
View article: Correlation of non-alcoholic fatty liver disease and gut microflora: clinical reports and treatment options
Correlation of non-alcoholic fatty liver disease and gut microflora: clinical reports and treatment options Open
A prevalent liver condition called non-alcoholic fatty liver disease (NAFLD) may progress into non-alcoholic steatohepatitis (NASH) and cause life-threatening complications like cirrhosis and liver cancer. The development and progression o…
View article: Abstract 1868 Fig4 Influences Cellular Homeostasis Through MAP Kinase Related Pathways
Abstract 1868 Fig4 Influences Cellular Homeostasis Through MAP Kinase Related Pathways Open
Fig4 is a highly conserved phosphoinositide (PI) phosphatase that plays crucial roles in human development and long-term health. Fig4 contributes to cellular homeostasis through dephosphorylating PI3,5P2 at the 5-position of the inositol h…
View article: Herbal Emulgel Containing Azadirachta indica (Neem) and Nigella Sativa L. (Black Cumin) Oils in Wound Management: Preclinical Investigations
Herbal Emulgel Containing Azadirachta indica (Neem) and Nigella Sativa L. (Black Cumin) Oils in Wound Management: Preclinical Investigations Open
Context: In wound management, traditional use of plants has received attention by the scientific community, as traditional medicines are a valuable source of affordable, comprehensive medical care. Azadirachta indica A. Juss (Neem) and Nig…
View article: Design and Synthesis of Folic Acid-Phytochemical Conjugates as Anti-Cancer Agents
Design and Synthesis of Folic Acid-Phytochemical Conjugates as Anti-Cancer Agents Open
Cancer treatment continues to be a major challenge for the medical community mainly due to non-specificity, leading to serious toxic effects. The use of vitamins such as folic acid and biotin are presently being studied through the synthes…
View article: Flash Chromatography and Semi-Preparative HPLC: Review on the Applications and Recent Advancements over the Last Decade
Flash Chromatography and Semi-Preparative HPLC: Review on the Applications and Recent Advancements over the Last Decade Open
Flash chromatography and Semi-Preparative High Performance Liquid Chromatography have showed themselves as promising separation tools. These techniques assist in the process of isolation, fractionation and purification of chemical, biologi…
View article: Total Polyphenolic Content, Antioxidant Activity and Chromatographic Profiling of Extracts of Ardissia solanacea
Total Polyphenolic Content, Antioxidant Activity and Chromatographic Profiling of Extracts of Ardissia solanacea Open
Pharmacognosy Research,2023,15,2,356-362.DOI:10.5530/pres.15.2.038Published:February 2023Type:Original Article Authors:Jyotsna Chopade, Asha Thomas, and Sohan Chitlange Author(s) affiliations:Jyotsna Chopade, Asha Thomas*, Sohan Chitlange …
View article: Prospective Hybrid Molecules with Dual Anti-Viral and Anti-Thrombotic Activity Against the SARS- CoV-2 Infection and Its Associated Complications Employing in Silico Studies
Prospective Hybrid Molecules with Dual Anti-Viral and Anti-Thrombotic Activity Against the SARS- CoV-2 Infection and Its Associated Complications Employing in Silico Studies Open
Covid-19, a SARS-CoV virus-based disease, was identified in Wuhan, China, in December 2019. Initially, it was considered just an infection of the respiratory system, but due to its transmittable nature, it was declared a pandemic. A variet…
View article: Organoselenium Compounds as Potential Therapeutic Agents for TreatingBrain Disorders
Organoselenium Compounds as Potential Therapeutic Agents for TreatingBrain Disorders Open
Among the inorganic elements, selenium is one of the essential entities required in trace amounts. Selenium (Se) has a vital role to play in brain physiology. It is well demonstrated that an abnormal level of selenium is the cause of the p…
View article: Phytochemical analysis of Clerodendron infortunatum Linn. leaves in various seasons by different solvent and extraction techniques
Phytochemical analysis of Clerodendron infortunatum Linn. leaves in various seasons by different solvent and extraction techniques Open
Clerodendron infortunatum Linn is widely used for the treatment of malaria and vermifuge, scorpion and snake bites, tumors, inflammation, bronchitis and in wound healing. The present study was carried out to estimate the variation in the a…
View article: An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats
An in-vivo herb-drug interaction study of Tinospora cordifolia extract on the pharmacokinetics of gliclazide in normal Wistar rats Open
Background and Aims: Tinospora cordifolia (Willd.) Miers (TC), from the Menispermaceae family, is a well-known traditional herb used to treat diabetes mellitus and a variety of other ailments, according to traditional Indian literature. He…
View article: Sporadic Hemiplegic Migraine with CACNA1A Mutation Masquerading as Acute Meningoencephalitis
Sporadic Hemiplegic Migraine with CACNA1A Mutation Masquerading as Acute Meningoencephalitis Open
Hemiplegic migraine (HM) is usually seen in developmentally normal children with a prevalence of 0.01%.[1] Genes implicated are CACNA1A, ATP1A2, ATP1A3, SCN1A, PRRT2, and SLC2A1.[23] CACNA1A mutations have associated features like global d…
View article: Role of Nitrogen containing heterocyclic compounds in Acyl co-A carboxylase carboxyltransferase: Docking with dynamic simulation studies
Role of Nitrogen containing heterocyclic compounds in Acyl co-A carboxylase carboxyltransferase: Docking with dynamic simulation studies Open
Acyl Co-A carboxylase carboxyltransferase (AccD5) is essential for cell wall lipid biosynthesis and its disruption leads to mycobacterial death.Acyl CoA is the key regulation point for fatty acid synthesis and therefore AccD5 has become a …
View article: Understanding the Molecular Mechanism of Phytoconstituents as Tyrosinase Inhibitors for Treatment of Hyperpigmentation
Understanding the Molecular Mechanism of Phytoconstituents as Tyrosinase Inhibitors for Treatment of Hyperpigmentation Open
Skin Pigmentation is a phenomenon in which the accumulation of melanin occurs due to various factors and leads to skin tanning and other skin disorders.Now a day's human beings are more conscious about quality of life and appearance.With t…
View article: Inhibition of Viper Venom-InducedToxicity by Moringa oleifera LeavesExtracts
Inhibition of Viper Venom-InducedToxicity by Moringa oleifera LeavesExtracts Open
Snakebite, a medical emergency, is a socially significant but neglected issue in India. Antivenom serum therapy that is currently used against venomous snakebites is expensive and showed severe side effects. Traditional claims reported the…
View article: Novel nitrogen-containing heterocyclic compounds in GPR109A as an anti-hyperlipidemic: Homology modeling, docking, dynamic simulation studies
Novel nitrogen-containing heterocyclic compounds in GPR109A as an anti-hyperlipidemic: Homology modeling, docking, dynamic simulation studies Open
Niacin or nicotinic acid therapy leads to reduction of the level of Low-density Lipoprotein cholesterol (20-40%) with significant elevation of High-Density Lipopreoin cholesterol level (20-35%). From research, it was said that Nicotinic ac…
View article: Roles for a lipid phosphatase in the activation of its opposing lipid kinase
Roles for a lipid phosphatase in the activation of its opposing lipid kinase Open
The phosphoinositide phosphatase Fig4 is predicted to turn over the signaling lipid PI3,5P2. It is shown that a major role of Fig4 is to elevate PI3,5P2 via dynamic regulation of the protein complex that activates its opposing lipid kinase…
View article: A High Performance Thin Layer Chromatographic Method Using a Design of Experiment Approach for Estimation of Phytochemicals in Extracts of <i>Moringa Oleifera</i> Leaves
A High Performance Thin Layer Chromatographic Method Using a Design of Experiment Approach for Estimation of Phytochemicals in Extracts of <i>Moringa Oleifera</i> Leaves Open
This validated HPTLC method developed through a DoE approach was successfully employed for quantification of GA, QT, and RT from Moringa oleifera extracts and may also be extended for their simultaneous estimation in other herbal extracts,…