Ashan Veerakumar
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View article: Affective bias predicts changes in depression during deep brain stimulation therapy
Affective bias predicts changes in depression during deep brain stimulation therapy Open
Introduction Deep brain stimulation (DBS) is a promising treatment for refractory depression, utilizing surgically implanted electrodes to stimulate specific anatomical targets within the brain. However, limitations of patient-reported and…
View article: Unilateral and Bilateral Theta Burst Stimulation for Treatment-Resistant Depression: Follow up on a Naturalistic Observation Study
Unilateral and Bilateral Theta Burst Stimulation for Treatment-Resistant Depression: Follow up on a Naturalistic Observation Study Open
Objectives Theta burst stimulation (TBS) is a novel and faster modality of transcranial magnetic stimulation, which is showing promise as a treatment-resistant depression (TRD) treatment. Though TBS can be applied unilaterally or bilateral…
View article: Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation
Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation Open
Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for refractory depression. Good clinical outcomes are associated with the activation of white matter adjacent to the SCC. This activation produces a signature …
View article: Cingulate dynamics track depression recovery with deep brain stimulation
Cingulate dynamics track depression recovery with deep brain stimulation Open
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error s…
View article: Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate
Time-frequency signatures evoked by single-pulse deep brain stimulation to the subcallosal cingulate Open
Precision targeting of specific white matter bundles that traverse the subcallosal cingulate (SCC) has been linked to efficacy of deep brain stimulation (DBS) for treatment resistant depression (TRD). Methods to confirm optimal target enga…
View article: Decoding depression during subcallosal cingulate deep brain stimulation
Decoding depression during subcallosal cingulate deep brain stimulation Open
A bstract Deep brain stimulation of subcallosal cingulate white matter (SCCwm-DBS) alleviates symptoms of treatment resistant depression (TRD) over months of therapy. Readouts of depression symptom severity derived from neural recordings a…
View article: Perimenopause and First-Onset Mood Disorders: A Closer Look
Perimenopause and First-Onset Mood Disorders: A Closer Look Open
Perimenopause is often a time of social, emotional, and physical change. Various factors contribute to the development of mood disorders during this time. There is a known association among women with previous history of major depressive d…
View article: Field potential 1/<i>f</i> activity in the subcallosal cingulate region as a candidate signal for monitoring deep brain stimulation for treatment-resistant depression
Field potential 1/<i>f</i> activity in the subcallosal cingulate region as a candidate signal for monitoring deep brain stimulation for treatment-resistant depression Open
Subcallosal cingulate cortex deep brain stimulation (SCC-DBS) is an experimental therapy for treatment-resistant depression (TRD). Refinement and optimization of SCC-DBS will benefit from increased study of SCC electrophysiology in context…
View article: Versatile genetic assembly system (VEGAS) to assemble pathways for expression in<i>S. cerevisiae</i>
Versatile genetic assembly system (VEGAS) to assemble pathways for expression in<i>S. cerevisiae</i> Open
We have developed a method for assembling genetic pathways for expression in Saccharomyces cerevisiae. Our pathway assembly method, called VEGAS (Versatile genetic assembly system), exploits the native capacity of S. cerevisiae to perform …