Ashish A. Deshmukh
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View article: The longitudinal effect of repetition and practice on the accuracy of lay anal examinations for detecting perianal and anal canal abnormalities: a prospective study
The longitudinal effect of repetition and practice on the accuracy of lay anal examinations for detecting perianal and anal canal abnormalities: a prospective study Open
View article: Vitamin B12 Protects Against Early Diabetic Kidney Injury and Alters Clock Gene Expression in Mice
Vitamin B12 Protects Against Early Diabetic Kidney Injury and Alters Clock Gene Expression in Mice Open
Vitamin B12 (B12) is a strong antioxidant and a cofactor for methionine synthase supporting DNA/RNA/protein methylation. We previously demonstrated that oral high-dose B12 supplement mitigates diabetic cardiomyopathy in Akita diabetic mice…
View article: The impact of multicancer early detection tests on cancer stage shift: A 10‐year microsimulation model
The impact of multicancer early detection tests on cancer stage shift: A 10‐year microsimulation model Open
Introduction Early detection of cancer improves survival following diagnosis. However, routine screening is limited to a few cancer types. Multicancer early detection (MCED) tests could revolutionize cancer screening by simultaneously dete…
View article: National Outcomes of Increasing Cervical Cancer Screening in Federally Qualified Health Centers
National Outcomes of Increasing Cervical Cancer Screening in Federally Qualified Health Centers Open
Importance Federally qualified health centers (FQHCs) deliver health care to more than 30 million people across the US and often face structural constraints that affect their ability to provide cervical cancer screening (CCS). Objectives T…
View article: Performance of the prototype Silicon Tracking System of the CBM experiment tested with heavy-ion beams at SIS18
Performance of the prototype Silicon Tracking System of the CBM experiment tested with heavy-ion beams at SIS18 Open
View article: Vitamin B12 Modulates Circadian Clock Genes and Protects Early Diabetic Kidney Injury
Vitamin B12 Modulates Circadian Clock Genes and Protects Early Diabetic Kidney Injury Open
Vitamin B12 (B12) is a co-factor for methionine synthase and supports DNA/RNA/protein methylation through S-adenosylmethionine production. We previously demonstrated that oral high-dose B12 supplement mitigates diabetic complications in Ak…
View article: Supplementary Figure S6 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S6 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Different therapeutic approaches utilizing the superiority of 3xTg T-cells in resisting tumor growth and progression.
View article: Supplementary Figure S5 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S5 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Fumarate supplementation reverses aging-induced mitophagy and transcriptional phenotype in old T-cells without affecting mouse behavior.
View article: Supplementary Figure S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
ATAD3 shuttles CerS6 to the mitochondria of aging T-cells and mitochondrial APP blocks this effect.
View article: Key Resources Table from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Key Resources Table from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
This file contains a key resources table that includes details of key experimental materials and supplies used in this study.
View article: Supplementary Table S4 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Table S4 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Demographic characteristics of human APP-high vs APP-low samples.
View article: Supplementary Figure S4 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S4 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Metabolic changes in old WT T-cells as measured by flux metabolomics.
View article: Supplementary Figure S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Aβ40, but not Aβ42, is sufficient but not necessary to inhibit mitophagy in aging T-cells.
View article: Supplementary Figure S7 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S7 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
T-cells from human AD patients with cancer show an increase in APP levels, a decrease in mitophagy, and an increase in cytokine production.
View article: Data from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Data from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Patients with Alzheimer's disease (AD) have a decreased incidence of cancer, with a cross-sectional analysis of a nationwide sample of adults finding 21-fold higher odds of cancer diagnosis in non-AD individuals compared with those with AD…
View article: Supplementary Table S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Table S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
List of diagnostic codes for cancer ascertainment in the Medical Expenditure Panel Survey.
View article: Supplementary Table S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Table S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Characteristics of AD cases and non-AD controls, 2016 to 2019 and 2021 Medical Expenditure Panel Survey (MEPS).
View article: Supplementary Figure S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Figure S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
T-cells of 3xTg mice, but not APP-PS1 mice, have a functional advantage and protect the mice from tumor growth and development.
View article: Supplementary Table S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Supplementary Table S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
List of diagnostic codes for cancer ascertainment in the Medical Expenditure Panel Survey.
View article: Anal cancer incidence among women with a history of vulvar cancer by histology, age, and time since diagnosis
Anal cancer incidence among women with a history of vulvar cancer by histology, age, and time since diagnosis Open
Women with a history of vulvar cancer face a high risk of anal cancer; however, incidence according to histology, age-at, and time since vulvar cancer diagnosis remains unexplored. Using data from SEER-8 and SEER-17 registries, we identifi…
View article: Anal Cancer Incidence Among Women With a History of Cervical Cancer by Age and Time Since Diagnosis
Anal Cancer Incidence Among Women With a History of Cervical Cancer by Age and Time Since Diagnosis Open
This cohort study estimates anal cancer incidence in women with a history of cervical cancer, by age and time since diagnosis.
View article: Magnitude of persistent poverty and cervical cancer incidence, stage at diagnosis, and mortality
Magnitude of persistent poverty and cervical cancer incidence, stage at diagnosis, and mortality Open
Socioeconomically disadvantaged counties exhibit higher cervical cancer incidence and poorer survival. However, the specific impact of the magnitude of persistent poverty on these outcomes remains largely unexamined. Using national cancer …
View article: County-Level Cervical Cancer Screening Coverage and Differences in Incidence and Mortality
County-Level Cervical Cancer Screening Coverage and Differences in Incidence and Mortality Open
This cross-sectional study evaluates differences between cervical cancer incidence and mortality in counties with high vs low screening rates.
View article: Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity
Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity Open
Patients with Alzheimer's disease (AD) have a decreased incidence of cancer, with a cross-sectional analysis of a nationwide sample of adults finding 21-fold higher odds of cancer diagnosis in non-AD individuals compared with those with AD…
View article: Gay and Bisexual Men in the US Lack Basic Information About Anal Cancer.
Gay and Bisexual Men in the US Lack Basic Information About Anal Cancer. Open
OBJECTIVE: The purpose of this study was to assess knowledge of human papillomavirus (HPV) as a cause of anal cancer among at-risk gay, bisexual, and other men who have sex with men (GBM). MATERIALS AND METHODS: Secondary analysis was cond…
View article: Self-Collection for Cervical Cancer Screening in a Safety-Net Setting
Self-Collection for Cervical Cancer Screening in a Safety-Net Setting Open
Importance There are limited data on the effectiveness of mailed self-collection to increase cervical cancer screening (CCS) participation in underresourced health care settings. Objective To compare the effectiveness of mailed self-collec…
View article: Reply to comments on: “International Anal Neoplasia Society's consensus guidelines for anal cancer screening”
Reply to comments on: “International Anal Neoplasia Society's consensus guidelines for anal cancer screening” Open
View article: Rural-Urban Disparities in Cervical Cancer Incidence and Mortality Among US Women
Rural-Urban Disparities in Cervical Cancer Incidence and Mortality Among US Women Open
This cross-sectional study examines rural-urban disparities in cervical cancer incidence and mortality among US women.
View article: 2024 Anal Cancer Screening Guidelines: Analysis of Clinical Performance and Use of High-Resolution Anoscopy in a Large Cohort of Persons With HIV
2024 Anal Cancer Screening Guidelines: Analysis of Clinical Performance and Use of High-Resolution Anoscopy in a Large Cohort of Persons With HIV Open
Recently published anal cancer screening guidelines recommend 5 strategies for high-risk populations using combinations of cytology and high-risk human papillomavirus testing. Based on data from 1223 persons with human immunodeficiency vir…
View article: An Observational Cross-sectional Study of Darun Rasavaha Strotodushti in Aamvata as a Hetu of Pranvaha Strotodushti with Special Reference to Interstitial Lung Disease in Rheumatoid Arthritis
An Observational Cross-sectional Study of Darun Rasavaha Strotodushti in Aamvata as a Hetu of Pranvaha Strotodushti with Special Reference to Interstitial Lung Disease in Rheumatoid Arthritis Open
Background: Aamvata, described in Ayurvedic classics as a disease of Rasavaha Strotas, often manifests with systemic features. Classical texts such as Charaka Samhita describe that a Daruna (severe) involvement of any strotas can be a caus…