Ashish Lal
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View article: Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19
Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19 Open
Sigma-1 receptor (S1R) is a Ca 2+ sensitive, ligand-operated receptor chaperone protein present on the endoplasmic reticulum (ER) membrane and more specifically at the mitochondria-associated ER membrane (MAM). Upon activation by ER calciu…
View article: HNRNPH1-mediated splicing events regulate EIF4G1 transcript variant composition and the organization of the AURKA 5' UTR
HNRNPH1-mediated splicing events regulate EIF4G1 transcript variant composition and the organization of the AURKA 5' UTR Open
HNRNPH1 is a regulator of alternative splicing, but few studies have defined the splicing events it mediates. Here, we used short- and long-read RNA sequencing to interrogate the transcriptome-wide effects of HNRNPH1 depletion and its regu…
View article: p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration Open
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing regulator that functions in p53-dependent tum…
View article: p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration Open
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing regulator that functions in p53-dependent tum…
View article: Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression
Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression Open
RNASE1 is a ribonuclease secreted by cells and degrades extracellular RNAs. Here, we unexpectedly found that RNASE1, in addition to being secreted, is predominantly localized to the nucleus and functions to inhibit gene expression in human…
View article: p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration
p53-induced RNA-binding protein ZMAT3 inhibits transcription of a hexokinase to suppress mitochondrial respiration Open
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence indicates that the p53-induced RNA-binding protein ZMAT3 acts as a key splicing regulator that contributes to p53-depen…
View article: eLife Assessment: Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C
eLife Assessment: Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C Open
View article: eLife Assessment: Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C
eLife Assessment: Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C Open
View article: BENZOMORPHAN AND NON-BENZOMORPHAN AGONISTS DIFFERENTIALLY ALTER SIGMA-1 RECEPTOR QUATERNARY STRUCTURE, AS DOES TYPES OF CELLULAR STRESS
BENZOMORPHAN AND NON-BENZOMORPHAN AGONISTS DIFFERENTIALLY ALTER SIGMA-1 RECEPTOR QUATERNARY STRUCTURE, AS DOES TYPES OF CELLULAR STRESS Open
Background Sigma-1 receptor (S1R) is a calcium-sensitive, ligand-operated receptor chaperone protein present on the endoplasmic reticulum (ER) membrane and more specifically at the mitochondria- associated endoplasmic reticulum membrane (M…
View article: eLife Assessment: Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress
eLife Assessment: Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress Open
View article: Evaluating the Risk of Traumatic Brain Injury in Adults Following a Fall With Concomitant Use of Anti-Coagulation: A Retrospective Cohort Study
Evaluating the Risk of Traumatic Brain Injury in Adults Following a Fall With Concomitant Use of Anti-Coagulation: A Retrospective Cohort Study Open
Introduction Falls and fractures are major health challenges for older adults in England. Despite the advantages of anticoagulants, their use in the elderly is often restricted due to concerns about fall-related injuries. However, there is…
View article: eLife Assessment: Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress
eLife Assessment: Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress Open
Cells react to stress by triggering response pathways, leading to extensive alterations in the transcriptome to restore cellular homeostasis. The role of RNA metabolism in shaping the cellular response to stress is vital, yet the global ch…
View article: Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells
Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells Open
Transcription factors play key roles in development and disease by controlling gene expression. Forkhead Box A1 (FOXA1), a pioneer transcription factor essential for mouse development and functions as an oncogene in prostate and breast can…
View article: Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress
Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stress Open
View article: Supplementary Figure 1 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 1 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 1. miR-450a overexpression and effects in SKOV-3 ovarian cancer cell line.
View article: Supplementary Figure 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 2. miR-450b similar seed sequence and effects after its overexpression.
View article: Supplementary Figure 4 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 4 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 4. miR-450a effects on glutamine uptake and glutamate production.
View article: Supplementary Figure 3 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 3 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 3. Protein blot from AGO proteins from nuclear and cytoplasmic portions of A2780.
View article: Supplementary Table 1b from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 1b from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 1. List of potential total miRNA and miR-450a only binding sites from A2780 cell line and expressing miR-450a
View article: Supplementary Table 1a from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 1a from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 1a. List of potential total miRNA and miR-450a only binding sites from A2780 control cell line
View article: Supplementary Table 1a from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 1a from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 1a. List of potential total miRNA and miR-450a only binding sites from A2780 control cell line
View article: Supplementary Table 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 2. List of targets from miR-450a derived from PAR-CLIP analysis.
View article: Supplementary Figure 4 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 4 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 4. miR-450a effects on glutamine uptake and glutamate production.
View article: Supplementary Table 1b from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 1b from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 1. List of potential total miRNA and miR-450a only binding sites from A2780 cell line and expressing miR-450a
View article: Supplementary Figure 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 2. miR-450b similar seed sequence and effects after its overexpression.
View article: Supplementary Figure 3 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Figure 3 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Figure 3. Protein blot from AGO proteins from nuclear and cytoplasmic portions of A2780.
View article: Supplementary Table 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Table 2 from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Supplementary Table 2. List of targets from miR-450a derived from PAR-CLIP analysis.
View article: Data from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Data from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Dysregulation of miRNA expression is associated with multiple diseases, including cancers, in which small RNAs can have either oncogenic or tumor suppressive functions. Here we investigated the potential tumor suppressive function of miR-4…
View article: Data from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Data from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Dysregulation of miRNA expression is associated with multiple diseases, including cancers, in which small RNAs can have either oncogenic or tumor suppressive functions. Here we investigated the potential tumor suppressive function of miR-4…
View article: Supplementary Material from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism
Supplementary Material from miR-450a Acts as a Tumor Suppressor in Ovarian Cancer by Regulating Energy Metabolism Open
Contains detailed Supplementary Figure and Table legends