Ashish Sarraju
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View article: Lipoprotein(a) in clinical practice: What clinicians need to know
Lipoprotein(a) in clinical practice: What clinicians need to know Open
Elevated lipoprotein(a) is an independent risk factor for atherosclerotic cardiovascular disease and aortic valve stenosis. Current lipid-lowering treatments have a minimal impact on lipoprotein(a) levels, but emerging therapies show promi…
View article: Speaking the Language of Inclusion
Speaking the Language of Inclusion Open
View article: From LDL-C to lipoprotein(a) - those who fail to learn from history are doomed to repeat it
From LDL-C to lipoprotein(a) - those who fail to learn from history are doomed to repeat it Open
Reducing plasma low-density lipoprotein cholesterol (LDL-C) levels is a critical component of managing atherosclerotic cardiovascular disease (ASCVD) risk. However, LDL-C goal attainment and the use of LDL-C lowering therapies, which inclu…
View article: Association of Systolic Blood Pressure Time in Target Range With Cardiovascular Events Among PRECISION Participants
Association of Systolic Blood Pressure Time in Target Range With Cardiovascular Events Among PRECISION Participants Open
Blood pressure (BP) is a dynamic vital sign with variability. Novel metrics that account for BP variability and longitudinal control are gaining interest, such as time in target range (TTR) assessments. TTR is the percentage of time a pati…
View article: Speaking the Language of Inclusion: Examining English Languages Requirements in Cardiovascular Digital Health Trials
Speaking the Language of Inclusion: Examining English Languages Requirements in Cardiovascular Digital Health Trials Open
Background Cardiovascular medicine is rapidly evolving, as it integrates digital technologies intended to decentralize care from the clinic and/or hospital setting into patient’s homes and communities. However, clinical trials of digital t…
View article: Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans
Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans Open
Objective South Asians (SAs) may possess a unique predisposition to insulin resistance (IR). We explored this possibility by investigating the relationship between ‘gold standard’ measures of adiposity, fitness, selected proteomic biomarke…
View article: Comparative Analysis of the Accuracy of Large Language Models in Addressing Common Pulmonary Embolism Patient Questions
Comparative Analysis of the Accuracy of Large Language Models in Addressing Common Pulmonary Embolism Patient Questions Open
View article: Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans
Associations between accurate measures of adiposity and fitness, blood proteins, and insulin sensitivity among South Asians and Europeans Open
Objective South Asians (SAs) may possess a unique predisposition to insulin resistance (IR). We explored this possibility by investigating the relationship between ‘gold standard’ measures of adiposity, fitness, selected proteomic biomarke…
View article: EVALUATING MISINFORMATION REGARDING CARDIOVASCULAR DISEASE PREVENTION OBTAINED ON A POPULAR, PUBLICLY ACCESSIBLE ARTIFICIAL INTELLIGENCE MODEL (GPT-4)
EVALUATING MISINFORMATION REGARDING CARDIOVASCULAR DISEASE PREVENTION OBTAINED ON A POPULAR, PUBLICLY ACCESSIBLE ARTIFICIAL INTELLIGENCE MODEL (GPT-4) Open
Therapeutic Area: Other: Artificial intelligence; Misinformation Background: Misinformation regarding CVD prevention is prevalent on the internet and on social media. Chat-based artificial intelligence (AI) models such as ChatGPT have gain…
View article: Navigating the Gray Zone
Navigating the Gray Zone Open
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View article: Obicetrapib—the Rebirth of CETP Inhibitors?
Obicetrapib—the Rebirth of CETP Inhibitors? Open
View article: Impact of the COVID‐19 Pandemic on Conduct and Results of CLEAR Outcomes Trial
Impact of the COVID‐19 Pandemic on Conduct and Results of CLEAR Outcomes Trial Open
Introduction The COVID‐19 pandemic disrupted clinical research. CLEAR Outcomes investigated the effect of bempedoic acid (BA) versus placebo in 13 970 patients with statin intolerance and high cardiovascular (CV) risk. BA reduced the risk …
View article: Using large language models to assess public perceptions around glucagon-like peptide-1 receptor agonists on social media
Using large language models to assess public perceptions around glucagon-like peptide-1 receptor agonists on social media Open
Background The prevalence of obesity has been increasing worldwide, with substantial implications for public health. Obesity is independently associated with cardiovascular morbidity and mortality and is estimated to cost the health system…
View article: Effects of canagliflozin on total heart failure events across the kidney function spectrum: Participant‐level pooled analysis from the <scp>CANVAS</scp> Program and <scp>CREDENCE</scp> trial
Effects of canagliflozin on total heart failure events across the kidney function spectrum: Participant‐level pooled analysis from the <span>CANVAS</span> Program and <span>CREDENCE</span> trial Open
Aims People with type 2 diabetes (T2D) face high risks of heart failure (HF) hospitalizations that are often recurrent, especially as kidney function declines. We examined the effects of canagliflozin on total HF events by baseline kidney …
View article: Lipoprotein(a) Levels in Disaggregated Racial and Ethnic Subgroups Across Atherosclerotic Cardiovascular Disease Risk Levels
Lipoprotein(a) Levels in Disaggregated Racial and Ethnic Subgroups Across Atherosclerotic Cardiovascular Disease Risk Levels Open
Lp(a) testing is performed infrequently. Of those tested, Lp(a) levels were frequently elevated and differed significantly across disaggregated race and ethnicity groups. The prevalence of elevated Lp(a) increased with increasing ASCVD ris…
View article: Patterns and gaps in guideline-directed statin use for atherosclerotic cardiovascular disease by race and ethnicity
Patterns and gaps in guideline-directed statin use for atherosclerotic cardiovascular disease by race and ethnicity Open
In patients with incident ASCVD, we describe suboptimal and heterogenous 1-year post-ASCVD guideline-directed statin use and 1-year post-ASCVD LDL-c control across disaggregated race and ethnicity groups. Findings may improve understanding…
View article: Evaluation of Prompts to Simplify Cardiovascular Disease Information Generated Using a Large Language Model: Cross-Sectional Study
Evaluation of Prompts to Simplify Cardiovascular Disease Information Generated Using a Large Language Model: Cross-Sectional Study Open
In this cross-sectional study, we evaluated the completeness, readability, and syntactic complexity of cardiovascular disease prevention information produced by GPT-4 in response to 4 kinds of prompts.
View article: Design and Implementation of an Electronic Health Record‐Integrated Hypertension Management Application
Design and Implementation of an Electronic Health Record‐Integrated Hypertension Management Application Open
Background High blood pressure affects approximately 116 million adults in the United States. It is the leading risk factor for death and disability across the world. Unfortunately, over the past decade, hypertension control rates have dec…
View article: Reply
Reply Open
View article: Comparative Analysis of Chat‐Based Artificial Intelligence Models in Addressing Common and Challenging Valvular Heart Disease Clinical Scenarios
Comparative Analysis of Chat‐Based Artificial Intelligence Models in Addressing Common and Challenging Valvular Heart Disease Clinical Scenarios Open
View article: Underrepresentation of Women in Reduced Ejection Heart Failure Clinical Trials With Improved Mortality or Hospitalization
Underrepresentation of Women in Reduced Ejection Heart Failure Clinical Trials With Improved Mortality or Hospitalization Open
View article: Evaluation of Prompts to Simplify Cardiovascular Disease Information Using a Large Language Model
Evaluation of Prompts to Simplify Cardiovascular Disease Information Using a Large Language Model Open
AI chatbots powered by large language models (LLMs) are emerging as an important source of public-facing medical information. Generative models hold promise for producing tailored guidance at scale, which could advance health literacy and …
View article: Readability and reliability of online patient education materials about statins
Readability and reliability of online patient education materials about statins Open
Statin OPEMs are written at an overall averaging reading grade level of 10.9. There was an inverse association between readability and reliability. Lack of accessible, high-quality online health information may contribute to statin nonadhe…
View article: DIFFERENCES IN LIPOPROTEIN(A) BY RACE, ETHNICITY, AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK
DIFFERENCES IN LIPOPROTEIN(A) BY RACE, ETHNICITY, AND ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK Open
Therapeutic Area: ASCVD/CVD Risk Factors Background: Lipoprotein(a) [Lp(a)] is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD). Despite practice guidelines recommending routine Lp(a) testing, uptake of screening has…
View article: The Opportunities and Challenges of Large Language Models in Cardiology
The Opportunities and Challenges of Large Language Models in Cardiology Open
View article: Evaluating Recommendations About Atrial Fibrillation for Patients and Clinicians Obtained From Chat-Based Artificial Intelligence Algorithms
Evaluating Recommendations About Atrial Fibrillation for Patients and Clinicians Obtained From Chat-Based Artificial Intelligence Algorithms Open
View article: Assessing the Accuracy of an Online Chat-Based Artificial Intelligence Model in Providing Recommendations on Hypertension Management in Accordance With the 2017 American College of Cardiology/American Heart Association and 2018 European Society of Cardiology/European Society of Hypertension Guidelines
Assessing the Accuracy of an Online Chat-Based Artificial Intelligence Model in Providing Recommendations on Hypertension Management in Accordance With the 2017 American College of Cardiology/American Heart Association and 2018 European Society of Cardiology/European Society of Hypertension Guidelines Open
View article: The leaky pipeline of diverse race and ethnicity representation in academic science and technology training in the United States, 2003–2019
The leaky pipeline of diverse race and ethnicity representation in academic science and technology training in the United States, 2003–2019 Open
Introduction Diverse race and ethnicity representation remains lacking in science and technology (S&T) careers in the United States (US). Due to systematic barriers across S&T training stages, there may be sequential loss of diverse repres…
View article: Artificial Intelligence–Enabled Analysis of Statin-Related Topics and Sentiments on Social Media
Artificial Intelligence–Enabled Analysis of Statin-Related Topics and Sentiments on Social Media Open
Importance Despite compelling evidence that statins are safe, are generally well tolerated, and reduce cardiovascular events, statins are underused even in patients with the highest risk. Social media may provide contemporary insights into…
View article: Natural language processing to identify reasons for sex disparity in statin prescriptions
Natural language processing to identify reasons for sex disparity in statin prescriptions Open
Women with ASCVD were less likely to be prescribed guideline-directed statins compared with men. NLP identified additional sex-based statin disparities and reasons for statin non-prescription in clinical notes of patients with ASCVD.