Ashley Dumont YOU? Author Swipe

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Correction for Oom et al., “The two-dose MVA-BN mpox vaccine induces a nondurable and low avidity MPXV-specific antibody response” Open

Aaron L. Oom, Kesi K. Wilson, Miilani Yonatan, Stephanie Rettig, Heekoung Youn , et al. · 2025

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models Open

Jan Poolman, Victor J. Torres, Dominique Missiakas, Suzanne P. M. Welten, J. L. Soveranes Fernández , et al. · 2025

Microbiota and metabolic adaptation shape<i>Staphylococcus aureus</i>virulence and antimicrobial resistance during intestinal colonization Open

Chunyi Zhou, Miranda Pawline, Alejandro Pironti, Sabrina M. Morales, Andrew I. Perault , et al. · 2024

Depletion of microbiota increases susceptibility to gastrointestinal colonization and subsequent infection by opportunistic pathogens such as methicillin-resistant Staphylococcus aureus (MRSA). How the absence of gut microbiota impacts the…

Author response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Ji‐Sun Kim , et al. · 2024

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Ji‐Sun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Jisun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Reviewer #1 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Ji‐Sun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Author Response: Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Jisun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Jisun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Reviewer #2 (Public Review): Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Ji‐Sun Kim , et al. · 2024

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

The Two-dose MVA-BN Mpox Vaccine Induces a Nondurable and Low Avidity MPXV-specific Antibody Response Open

Aaron L. Oom, Angelica C Kottkamp, Kesi K. Wilson, Miilani Yonatan, Stephanie Rettig , et al. · 2024

The 2022 global outbreak of clade IIb mpox was the first major outbreak of mpox outside of African nations. To control the outbreak, public health officials began vaccination campaigns using the third-generation orthopoxvirus vaccine MVA-B…

Quorum-sensing agr system of Staphylococcus aureus primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Ji‐Sun Kim , et al. · 2023

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H2O2, a crucial host defense against S. aureus. We now report that prot…

Quorum-sensing <i>agr</i> system of <i>Staphylococcus aureus</i> primes gene expression for protection from lethal oxidative stress Open

Magdalena Podkowik, Andrew I. Perault, Gregory Putzel, Andrew W. Pountain, Jisun Kim , et al. · 2023

The agr quorum-sensing system links Staphylococcus aureus metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of H 2 O 2 , a crucial host defense against S. aureus . We now report that…

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin Open

András N. Spaan, Anna‐Lena Neehus, Emmanuel Laplantine, Frederik Staels, Masato Ogishi , et al. · 2022

The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patien…

Vaccination With Detoxified Leukocidin AB Reduces Bacterial Load in a <i>Staphylococcus aureus</i> Minipig Deep Surgical Wound Infection Model Open

Jeffrey Fernandez, Holly Sanders, Jessica Henn, Jolaine M. Wilson, Danielle Malone , et al. · 2021

Vaccines against Staphylococcus aureus have eluded researchers for >3 decades while the burden of staphylococcal diseases has increased. Early vaccine attempts mainly used rodents to characterize preclinical efficacy, and all subsequent…

Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders Open

Phil H. Lee, Verneri Anttila, Hyejung Won, Yen‐Chen Anne Feng, Jacob Rosenthal , et al. · 2019

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls Open

Jonathan R. I. Coleman, Héléna A. Gaspar, Julien Bryois, Gerome Breen, Enda M. Byrne , et al. · 2019

Genome-wide association study identifies 30 loci associated with bipolar disorder Open

Eli A. Stahl, Gerome Breen, Andreas J. Forstner, Andrew McQuillin, Stephan Ripke , et al. · 2019

Identification of common genetic risk variants for autism spectrum disorder Open

Jakob Grove, Stephan Ripke, Thomas D. Als, Manuel Mattheisen, Raymond K. Walters , et al. · 2019

Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language Open

Ellen Verhoef, Ditte Demontis, Stephen Burgess, Chin Yang Shapland, Philip S. Dale , et al. · 2019

Schizophrenia risk conferred by protein-coding <i>de novo</i> mutations Open

Daniel P. Howrigan, Samuel A. Rose, Kaitlin E. Samocha, Menachem Fromer, Felecia Cerrato , et al. · 2018

Protein-coding de novo mutations (DNMs) in the form of single nucleotide changes and short insertions/deletions are significant genetic risk factors for autism, intellectual disability, developmental delay, and epileptic encephalopathy. In…

Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder Open

Ditte Demontis, Raymond K. Walters, Joanna Martin, Manuel Mattheisen, Thomas D. Als , et al. · 2018

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no variants have …

Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis Open

Eva Velthorst, Seán Froudist‐Walsh, Eli A. Stahl, Douglas M. Ruderfer, Ilyan Ivanov , et al. · 2018

While psychotic experiences (PEs) are assumed to represent psychosis liability, general population studies have not been able to establish significant associations between polygenic risk scores (PRS) and PEs. Previous work suggests that PE…

Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder Open

Eli A. Stahl, Gerome Breen, Andreas J. Forstner, Andrew McQuillin, Stephan Ripke , et al. · 2017

Bipolar disorder is a highly heritable psychiatric disorder that features episodes of mania and depression. We performed the largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, wit…

Discovery of the first genome-wide significant risk loci for ADHD Open

Ditte Demontis, Raymond K. Walters, Joanna Martin, Manuel Mattheisen, Thomas D. Als , et al. · 2017

Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% of adults. Common genetic variants contribute substantially to ADHD susceptibility, but no ind…

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders Open

Daniel J. Weiner, Emilie M. Wigdor, Stephan Ripke, Raymond K. Walters, Jack A. Kosmicki , et al. · 2017

Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASDs and to identify subgroups of ASD cases, including those with strong acting de novo va…

Type II Secretion-Dependent Degradative and Cytotoxic Activities Mediated by Stenotrophomonas maltophilia Serine Proteases StmPr1 and StmPr2 Open

Ashley Dumont, Sara M. Karaba, Nicholas P. Cianciotto · 2015

Stenotrophomonas maltophilia is an emerging opportunistic pathogen that primarily causes pneumonia and bacteremia in immunocompromised individuals. We recently reported that S. maltophilia strain K279a encodes the Xps type II secretion sys…

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular Open

Jason H. Melehani, David B. A. James, Ashley Dumont, Victor J. Torres, Joseph A. Duncan · 2015

Staphylococcus aureus infections are a growing health burden worldwide, and paramount to this bacterium's pathogenesis is the production of virulence factors, including pore-forming leukotoxins. Leukocidin A/B (LukAB) is a recently discove…

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular Open

Jason H. Melehani, David B. A. James, Ashley Dumont, Victor J. Torres, Joseph A. Duncan · 2015

Staphylococcus aureus infections are a growing health burden worldwide, and paramount to this bacterium’s pathogenesis is the production of virulence factors, including pore-forming leukotoxins. Leukocidin A/B (LukAB) is a recently discove…

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