Ashley E. Strother
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View article: Genetic Diversity Does Not Contribute to Attenuation of HeLa Passaged Wild-Type Yellow Fever Virus Strain French Viscerotropic Virus
Genetic Diversity Does Not Contribute to Attenuation of HeLa Passaged Wild-Type Yellow Fever Virus Strain French Viscerotropic Virus Open
The disease yellow fever was prevented by two live attenuated vaccines, strains 17D and French neurotropic vaccine (FNV), derived by serial passage of wild-type (WT) strains Asibi and French Viscerotropic virus (FVV), respectively. Both 17…
View article: Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development
Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development Open
View article: A partial T-DNA insertion near KNAT1 results in lobed Arabidopsis thaliana leaves
A partial T-DNA insertion near KNAT1 results in lobed Arabidopsis thaliana leaves Open
T-DNA tagging is a method to generate mutations in plants by random insertion. It is an important tool for the study of gene function in Arabidopsis because it allows you to see how the plant responds when expression of a specific protein …
View article: Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex
Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex Open
Live-attenuated viral vaccines are highly safe and efficacious but represent complex and often multigenic attenuation mechanisms. Most of these vaccines have been generated empirically by serial passaging of a wild-type (WT) virus in cell …
View article: Targeted Insertion of the mPing Transposable Element
Targeted Insertion of the mPing Transposable Element Open
Class II DNA Transposable Elements (TEs) are moved from one location to another in the genome by the action of transposase proteins that bind to repeat sequences at the ends of the elements. Although the location TE insertion is mostly ran…
View article: Precise repair of mPing excision sites is facilitated by target site duplication derived microhomology
Precise repair of mPing excision sites is facilitated by target site duplication derived microhomology Open
Together these results indicate that the difference in Tourist and Stowaway excision sites results from transposition mechanism characteristics. The TSDs of both elements play a role in element excision, but only the mPing TSDs actively pa…