Ashley E. Walker
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The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure Open
Age-related increases in arterial stiffness and pulse pressure are associated with cerebrovascular dysfunction; yet sex differences in these factors remain unclear. We found that cerebral artery passive stiffness was greater with age, inde…
View article: WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular deficits, and white matter damage, which are modified by humanized APOE alleles.
WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular deficits, and white matter damage, which are modified by humanized APOE alleles. Open
Vascular contributions are now widely accepted to play a key role in many cases of dementia, including Alzheimers disease (AD), that commonly manifest as cerebral small vessel diseases, including cerebral amyloid angiopathy (CAA). However,…
Cerebral blood flow in elastin haploinsufficient and 3xTg-AD mice Open
Artery structural properties and Alzheimer's disease (AD) pathology are individually associated with impaired cerebrovascular function; however, the interaction of these factors is unclear. Furthermore, while elastin haploinsufficient (Eln…
<i>APOE4</i> genotype negates the benefits of 17β-estradiol on cerebrovascular endothelial and mitochondrial function Open
Background Postmenopausal females who carry an APOEε4 allele are at higher risk of late-onset Alzheimer’s Disease compared to age-matched APOEε4 males. Estrogen deficiency predisposes females to an increased risk of vascular, cognitive, an…
A Drug–Drug Interaction Study Evaluating the Pharmacokinetic Consequences of Obicetrapib Therapy on Atorvastatin or Rosuvastatin Levels in Healthy Volunteers Open
NCT06081166.
The Impact of Age and Sex on Cerebral and Large Artery Stiffness and the Response to Pulse Pressure Open
Vascular aging is characterized by a tandem increase in pulse pressure and large elastic artery stiffness. Greater stiffness of the large arteries leads to elevated pulse pressure transmitted into the cerebral circulation, causing dysfunct…
Sex differences in the response to high pulse pressure in APOE4 mice Open
Background Elevated arterial pulse pressure (PP) is associated with cognitive decline and Alzheimer’s disease (AD). High PP damages the brain vasculature by causing endothelial cell dysfunction. Stiffer cerebral arteries have an impaired a…
Sex differences in the impact of arterial stiffness on cerebrovascular function Open
Background Stiffening of the large arteries is a hallmark feature of vascular aging and is associated with cognitive impairment and Alzheimer’s disease pathology. Increased large artery stiffness leads to higher‐than‐normal pulse pressure …
Cerebral vascular mitochondrial function is dependent on APOE genotype and estrogen status Open
Background Postmenopausal females who carry an APOE4 allele are at higher risk of late‐onset Alzheimer’s Disease (LOAD) compared to age‐matched APOE4 males. Estrogen deficiency predisposes females to an increased risk of vascular, cognitiv…
View article: Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer’s disease
Deletion of Robo4 worsens neuroinflammation and motor coordination in a mouse model of Alzheimer’s disease Open
Declines in vascular integrity are potential contributors to Alzheimer’s disease (AD) as these result in increased blood-brain barrier permeability and, as a consequence, accelerate neuroinflammation and cognitive impairment. Roundabout gu…
Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclinical models Open
With advancing age, the cerebral vasculature becomes dysfunctional, and this dysfunction is associated with cognitive decline. However, the initiating cause of these age-related cerebrovascular impairments remains incompletely understood. …
Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice Open
To properly design experiments, we must consider how variables like diet impact our outcomes, particularly the effects of soy on females. We found that cerebral artery vasodilation in response to insulin was impaired in ovariectomized fema…
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis Open
Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeabil…
Long-Acting Injectable Antipsychotics CVs. Oral Antipsychotics in Treatment Adherence: Efficacy and Equity of Care Open
The purpose of this DNP project is to compare if medication treatment adherence is greater in clients with schizophrenia who utilize oral antipsychotics (OAP) Vs. long-acting injectable antipsychotics medication (LAI).• Specific Aims -Dete…
Advancing age increases the size and severity of spontaneous atheromas in mouse models of atherosclerosis Open
Using multiple mouse models, we explored the impact of aging on the size and severity of atherosclerotic lesions. In young, middle-aged and old apolipoprotein E knockout mice (ApoE −/− ) fed an atherogenic diet (AD) for 3–8 weeks, plaque/a…
In vivo arterial stiffness, but not isolated artery endothelial function, varies with the mouse estrous cycle Open
To design rigorous vascular research studies using young female rodents, the influence of the estrous cycle on vascular function must be known. We found that in vivo aortic stiffness was lower during estrus compared with the diestrus phase…
View article: Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice
Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice Open
Age-related increases in large artery stiffness are associated with cerebrovascular dysfunction and cognitive impairment. Pyridoxamine treatment prevents large artery stiffening with advancing age, but the effects of pyridoxamine treatment…
Sex Differences in Large Artery Stiffness: Implications for Cerebrovascular Dysfunction and Alzheimer’s Disease Open
Two in every three Alzheimer’s disease diagnoses are females, calling attention to the need to understand sexual dimorphisms with aging and neurodegenerative disease progression. Dysfunction and damage to the vasculature with aging are str…
Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice Open
Vascular endothelial function declines with age on average, but there is high variability in the magnitude of this decline within populations. Measurements of frailty, known as frailty index (FI), can be used as surrogates for biological a…
Large artery stiffness and brain health: insights from animal models Open
There are no effective treatments available to halt or reverse the progression of age-related cognitive decline and Alzheimer’s disease. Thus, there is an urgent need to understand the underlying mechanisms of disease etiology and progress…
Deletion of <i>Robo4</i> prevents high‐fat diet‐induced adipose artery and systemic metabolic dysfunction Open
Objective Accumulating evidence suggests the vascular endothelium plays a fundamental role in the pathophysiology of obesity by regulating the functional status of white adipose and systemic metabolism. Robo4 is expressed specifically in e…
Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness Open
New Findings What is the central question of this study? Greater large artery stiffness is associated with dysfunctional resistance artery vasodilatory responses, impaired memory and greater risk of Alzheimer's disease. However, it is unkn…
Telomere uncapping and vascular aging Open
Although most telomere biology research continues to focus on telomere shortening, there is increasing evidence that telomere deprotection, or “uncapping,” is more biologically and possibly clinically important. Telomeres form t-loops to p…