Ashley Keller
YOU?
Author Swipe
View article: Influence of Sex and Body Composition on Aerobic Capacity in Normal Weight Lean, Normal Weight Obese, and Obese Phenotypes
Influence of Sex and Body Composition on Aerobic Capacity in Normal Weight Lean, Normal Weight Obese, and Obese Phenotypes Open
Normal weight obesity (NWO) is a body composition phenotype that is associated with increased cardiometabolic risk and is characterized by a normal weight body mass index but elevated body fat. The purpose of this study was to determine se…
View article: A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of <i>Pseudomonas aeruginosa</i> in Patients with Bronchiectasis
A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of <i>Pseudomonas aeruginosa</i> in Patients with Bronchiectasis Open
Rationale: Pseudomonas aeruginosa infection is associated with worse outcomes in bronchiectasis. Impaired neutrophil antimicrobial responses contribute to bacterial persistence. Gremubamab is a bivalent, bispecific monoclonal antibody targ…
View article: (264) Prioritizing Sexual and Reproductive Health Research and Care for People with Cystic Fibrosis: A 2023 Workshop Report From the Cystic Fibrosis Foundation Sexual Health, Reproduction, and Gender Research (SHARING) Working Group
(264) Prioritizing Sexual and Reproductive Health Research and Care for People with Cystic Fibrosis: A 2023 Workshop Report From the Cystic Fibrosis Foundation Sexual Health, Reproduction, and Gender Research (SHARING) Working Group Open
Introduction With therapy advances, people with cystic fibrosis (CF) are living longer, healthier lives, and thus increasingly have general and CF-specific sexual and reproductive health (SRH) questions. The CF Foundation is supporting the…
View article: INTERPROFESSIONAL GERIATRIC ASSESSMENT CLINIC: STUDENT SKILL DEVELOPMENT AND PATIENT SATISFACTION
INTERPROFESSIONAL GERIATRIC ASSESSMENT CLINIC: STUDENT SKILL DEVELOPMENT AND PATIENT SATISFACTION Open
The University of Southern Indiana Interprofessional Geriatric Assessment Clinic (IGAC) provides interprofessional clinical experience to medical residents and health profession students using the Institute for Healthcare Improvement’s Age…
View article: A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens
A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens Open
Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant, nosocomial pathogens that cause health care–associated infections. We developed a protein-free vaccine composed of aluminum hydroxide, monophosphoryl…
View article: Prospectively evaluating maternal and fetal outcomes in the era of CFTR modulators: the MAYFLOWERS observational clinical trial study design
Prospectively evaluating maternal and fetal outcomes in the era of CFTR modulators: the MAYFLOWERS observational clinical trial study design Open
Introduction Therapeutic advances have markedly increased life expectancy for those with cystic fibrosis (CF), resulting in a median predicted survival over 50 years. Consequently, people with CF (pwCF) are living through their reproductiv…
View article: PD-L1 <sup>+</sup> neutrophils contribute to injury-induced infection susceptibility
PD-L1 <sup>+</sup> neutrophils contribute to injury-induced infection susceptibility Open
Neutrophils abandon infection control during wound repair.
View article: A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis
A Prospective Study of the Effects of Sex Hormones on Lung Function and Inflammation in Women with Cystic Fibrosis Open
Rationale: Epidemiologic studies demonstrate worse outcomes in women with cystic fibrosis (CF) than men. Women are colonized earlier with respiratory pathogens and have increased rates of pulmonary exacerbations after puberty and near ovul…
View article: Multidrug-resistant <em>Pseudomonas aeruginosa</em> from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime&ndash;avibactam
Multidrug-resistant <em>Pseudomonas aeruginosa</em> from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime–avibactam Open
Ceftazidime-avibactam demonstrated a significant in vitro activity against highly resistant P. aeruginosa sputum isolates from individuals with CF. Further evaluation of the cause of resistance and clinical impact of ceftazidime-avibactam …
View article: Multidrug-resistant Pseudomonas aeruginosa from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime–avibactam
Multidrug-resistant Pseudomonas aeruginosa from sputum of patients with cystic fibrosis demonstrates a high rate of susceptibility to ceftazidime–avibactam Open
Stan D Atkin,1 Shadaan Abid,1 Michael Foster,1 Moumita Bose,1 Ashley Keller,1 Rita Hollaway,2 Helio S Sader,3 David E Greenberg,1,4 James D Finklea,1 Mariana Castanheira,3 Raksha Jain1,4 1Department of Internal Medicine, University of Texa…
View article: Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates
Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Antibody MEDI3902, Are Conserved Among Diverse Global Clinical Isolates Open
Psl and PcrV are highly prevalent in global clinical isolates, suggesting MEDI3902 can mediate broad coverage against P. aeruginosa.
View article: Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature
Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature Open
Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and subversion mechanisms that work in concert to overcome immune recognition and e…
View article: <i>Pseudomonas aeruginosa</i>Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide
<i>Pseudomonas aeruginosa</i>Bacteremic Patients Exhibit Nonprotective Antibody Titers Against Therapeutic Antibody Targets PcrV and Psl Exopolysaccharide Open
A vast majority of P. aeruginosa BSI isolates express PcrV and Psl; however, patient sera most often lacked IgG and functionally active responses to these targets. These results suggest that therapies directed at PcrV and Psl could be a pr…