Ashley N Dalrymple
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View article: Changes in muscle activation and joint motion during walking after transtibial amputation with sensory feedback from spinal cord stimulation: a case study
Changes in muscle activation and joint motion during walking after transtibial amputation with sensory feedback from spinal cord stimulation: a case study Open
Objective . The goal of this study was to examine the effects of spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss of sensory feedback and alterations in gait biomecha…
View article: Characterizing spinal reflexes evoked by sensory spinal cord stimulation in people with lower-limb amputation
Characterizing spinal reflexes evoked by sensory spinal cord stimulation in people with lower-limb amputation Open
Restoring sensation in the missing limb using SCS excites spinal reflexes according to the expected rostral-caudal myotomes but does not disrupt the step cycle duration or limb alternation symmetry in people with transtibial amputation. Th…
View article: Hierarchical Reinforcement Learning Framework for Adaptive Walking Control Using General Value Functions of Lower-Limb Sensor Signals
Hierarchical Reinforcement Learning Framework for Adaptive Walking Control Using General Value Functions of Lower-Limb Sensor Signals Open
Rehabilitation technology is a natural setting to study the shared learning and decision-making of human and machine agents. In this work, we explore the use of Hierarchical Reinforcement Learning (HRL) to develop adaptive control strategi…
View article: Evaluation of gold helical microwire structure electrode for long-term rodent nerve stimulation
Evaluation of gold helical microwire structure electrode for long-term rodent nerve stimulation Open
Objective. The development of electrodes for chronic peripheral nerve stimulation faces several challenges, including complex compositions, intricate manufacturing processes, and high costs associated with the availability and fabrication …
View article: Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα and Aβ-Fibers in Rats Protocol v1
Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα and Aβ-Fibers in Rats Protocol v1 Open
This is a protocol for an experiment to characterize the recruitment and maintenance of action potential firing in Aα/β-fibers generated during tonic dorsal root ganglion stimulation (DRGS) applied over a range of clinically relevant stimu…
View article: Changes in Muscle Activation and Joint Motion During Walking After Transtibial Amputation with Sensory Feedback from Spinal Cord Stimulation: A Case Study
Changes in Muscle Activation and Joint Motion During Walking After Transtibial Amputation with Sensory Feedback from Spinal Cord Stimulation: A Case Study Open
Background The goal of this study was to examine the effects of spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss of sensory feedback and alterations in gait biomechan…
View article: Improving localization and measurements of M-waves using high-density surface electromyography
Improving localization and measurements of M-waves using high-density surface electromyography Open
This study introduces an innovative approach to enhancing evoked potential measurements using high-density surface electromyography (HD-sEMG). The precision and localization of evoked potentials are significantly improved by spatial filter…
View article: Measuring evoked responses in forearm muscles using high density surface electromyography (HDsEMG) v1
Measuring evoked responses in forearm muscles using high density surface electromyography (HDsEMG) v1 Open
Surface electromyography (sEMG) is useful for studying muscle function and controlling prosthetics, but crosstalk from nearby muscles often limits its effectiveness. High-density sEMG (HD-sEMG) improves spatial resolution, allowing for the…
View article: The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat Pain Protocol v1
The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat Pain Protocol v1 Open
This is a protocol for an experiment to compare afferent fiber recruitment by dorsal root ganglion (DRG) stimulation using an injectable polymer electrode (Injectrode‱) and a more traditional cylindrical stainless steel electrode. This pro…
View article: A preliminary study exploring the effects of transcutaneous spinal cord stimulation on spinal excitability and phantom limb pain in people with a transtibial amputation
A preliminary study exploring the effects of transcutaneous spinal cord stimulation on spinal excitability and phantom limb pain in people with a transtibial amputation Open
Objective . Phantom limb pain (PLP) is debilitating and affects over 70% of people with lower-limb amputation. Other neuropathic pain conditions correspond with increased spinal excitability, which can be measured using reflexes and F -wav…
View article: Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα/β-Fibers in Rats
Tonic Stimulation of Dorsal Root Ganglion Results in Progressive Decline in Recruitment of Aα/β-Fibers in Rats Open
DRGS produces a progressive and frequency-dependent reduction in ECAP amplitude that occurs within and above the frequency range used clinically to relieve pain. If DRGS-mediated analgesia relies on Aβ-fiber activation, then the frequency …
View article: Safety of mapping the motor networks in the spinal cord using penetrating microelectrodes in Yucatan minipigs
Safety of mapping the motor networks in the spinal cord using penetrating microelectrodes in Yucatan minipigs Open
OBJECTIVE The goal of this study was to assess the safety of mapping spinal cord locomotor networks using penetrating stimulation microelectrodes in Yucatan minipigs (YMPs) as a clinically translational animal model. METHODS Eleven YMPs we…
View article: Dynamic spinal reflex adaptation during locomotor adaptation
Dynamic spinal reflex adaptation during locomotor adaptation Open
This work presents direct evidence for spinal reflex modulation during locomotor adaptation. In particular, we show that reflexes can be modulated on-demand unilaterally during split-belt locomotor adaptation and speculate about reflex mod…
View article: Characterizing spinal reflexes evoked by spinal cord stimulation to restore sensation in people with lower-limb amputation
Characterizing spinal reflexes evoked by spinal cord stimulation to restore sensation in people with lower-limb amputation Open
Background People with lower-limb amputations lack sensory inputs from their missing limb, which increases their risk of falling. We recently demonstrated that spinal cord stimulation (SCS) can restore sensation in the missing lower limb. …
View article: Student Competition (Technology Innovation) ID 1985155
Student Competition (Technology Innovation) ID 1985155 Open
Background ISMS entails implanting micro-electrodes into the spinal cord to produce synergistic activations of the legs. To date, ISMS has produced in-place stepping in cats with complete spinal cord injury (SCI) (Saigal et al, 2004), and …
View article: Transcutaneous Spinal Cord Stimulation to Reduce Phantom Limb Pain in People with a Transtibial Amputation
Transcutaneous Spinal Cord Stimulation to Reduce Phantom Limb Pain in People with a Transtibial Amputation Open
Objective Phantom limb pain (PLP) is debilitating and affects over 70% of people with lower-limb amputation. Other neuropathic pain conditions correspond with increased spinal excitability, which can be measured using reflexes and F-waves.…
View article: Lifting as we climb: Experiences and recommendations from women in neural engineering
Lifting as we climb: Experiences and recommendations from women in neural engineering Open
Neural engineering is an emerging and multidisciplinary field in which engineering approaches are applied to neuroscience problems. Women are underrepresented in engineering fields, and indeed in science, technology, engineering, and mathe…
View article: Using a high-frequency carrier does not improve comfort of transcutaneous spinal cord stimulation
Using a high-frequency carrier does not improve comfort of transcutaneous spinal cord stimulation Open
Objective. Spinal cord neuromodulation has gained much attention for demonstrating improved motor recovery in people with spinal cord injury, motivating the development of clinically applicable technologies. Among them, transcutaneous spin…
View article: Spinal cord stimulation restores sensation, improves function, and reduces phantom pain after transtibial amputation
Spinal cord stimulation restores sensation, improves function, and reduces phantom pain after transtibial amputation Open
SUMMARY In the United States, over 1.5 million people live with lower-limb amputation. Existing prosthetic limbs do not restore somatosensory feedback from the limb, resulting in functional impairments including balance deficits and an inc…
View article: High-Frequency Stimulation Does Not Improve Comfort of Transcutaneous Spinal Cord Stimulation
High-Frequency Stimulation Does Not Improve Comfort of Transcutaneous Spinal Cord Stimulation Open
Spinal cord neuromodulation has gained much attention for demonstrating improved motor recovery in people with spinal cord injury, motivating the development of clinically applicable technologies. Among them, transcutaneous spinal cord sti…
View article: Augmented Transcutaneous Stimulation Using an Injectable Electrode: A Computational Study
Augmented Transcutaneous Stimulation Using an Injectable Electrode: A Computational Study Open
Minimally invasive neuromodulation technologies seek to marry the neural selectivity of implantable devices with the low-cost and non-invasive nature of transcutaneous electrical stimulation (TES). The Injectrode ® is a needle-delivered el…
View article: Augmented Transcutaneous Stimulation Using an Injectable Electrode
Augmented Transcutaneous Stimulation Using an Injectable Electrode Open
Minimally invasive neuromodulation technologies seek to marry the neural selectivity of implantable devices with the low-cost and non-invasive nature of transcutaneous electrical stimulation (TES). The Injectrode ® is a needle-delivered el…
View article: Stimulation of the dorsal root ganglion using an Injectrode <sup>®</sup>
Stimulation of the dorsal root ganglion using an Injectrode <sup>®</sup> Open
Objective . The goal of this work was to compare afferent fiber recruitment by dorsal root ganglion (DRG) stimulation using an injectable polymer electrode (Injectrode ® ) and a more traditional cylindrical metal electrode. Approach . We e…
View article: Stimulation of the Dorsal Root Ganglion using an Injectrode<sup>®</sup>
Stimulation of the Dorsal Root Ganglion using an Injectrode<sup>®</sup> Open
Objective The goal of this work was to compare afferent fiber recruitment by dorsal root ganglion (DRG) stimulation using an injectable polymer electrode (Injectrode ® ) and a more traditional cylindrical metal electrode. Approach We expos…
View article: Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode
Recruitment of Primary Afferents by Dorsal Root Ganglion Stimulation using the Injectrode Open
Chronic pain affects millions of people in the United States and pharmacological treatments have been ineffective. Dorsal root ganglion (DRG) stimulation is a neuromodulation method that delivers electrical stimulation to the DRG to reliev…
View article: Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities
Platinum dissolution and tissue response following long-term electrical stimulation at high charge densities Open
Objective . Established guidelines for safe levels of electrical stimulation for neural prostheses are based on a limited range of the stimulus parameters used clinically. Recent studies have reported particulate platinum (Pt) associated w…