Ashlyn C. Harmon
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Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice Open
Our data indicate that inhaled DCB230 can act as an adjuvant, exacerbating asthma through IL-17-mediated responses in a HDM mouse model.
Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia Open
Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously shown that CD4+ T cells isolated from women with PE cau…
Inhalation of particulate matter containing free radicals leads to decreased vascular responsiveness associated with an altered pulmonary function Open
Particulate matter (PM) resulting from the combustion of organic matter is known to contribute to cardiopulmonary disease. Despite hypotheses that cardiovascular dysfunction occurring after PM exposures is secondary to lung or systemic inf…
<sup>177</sup>Lu-Labeled Eu-Doped Mesoporous SiO<sub>2</sub> Nanoparticles as a Theranostic Radiopharmaceutical for Colorectal Cancer Open
Copyright © 2020 American Chemical Society. Colorectal cancer is one of the most significant types of cancer, ranking second in the world's mortality cases. As colorectal cancer is often diagnosed at a late stage of disease progression, ef…
Mechanistic studies of cytotoxic activity of the mesoionic compound MIH 2.4Bl in MCF‑7 breast cancer cells Open
In the present study, the cytotoxic effects of a 1,3-thiazolium-5-thiolate derivative of a mesoionic compound, MIH 2.4Bl, were assessed in the MCF-7 breast cancer cell line. The cytotoxic effects of MIH 2.4Bl were determined using a crysta…
Cytotoxic Activity of the Mesoionic Compound MIH 2.4Bl in Breast Cancer Cell Lines Open
In this work, we report the synthesis of a new 1,3-thiazolium-5-thiolate derivative of a mesoionic compound (MIH 2.4Bl) and the characterization of its selective cytotoxicity on a panel of breast cancer cells lines. The cytotoxic effect of…
View article: Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats
Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats Open
Preeclampsia (PE) is characterized by chronic inflammation and elevated agonistic autoantibodies to the angiotensin type 1 receptor (AT 1 -AA), endothelin-1, and uterine artery resistance index (UARI) during pregnancy. Previous studies rep…
Particulate matter containing environmentally persistent free radicals induces AhR-dependent cytokine and reactive oxygen species production in human bronchial epithelial cells Open
Particulate matter (PM) is emitted during the combustion of fuels and wastes. PM exposure exacerbates pulmonary diseases, and the mechanism may involve oxidative stress. At lower combustion temperatures such as occurs in the cool zone of a…
Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy Open
Problem Preeclampsia (PE) is associated with inflammation and decreased Treg cells and IL‐10. The reduced uterine perfusion pressure (RUPP) rat model of PE exhibits these characteristics, and we hypothesized that induction of endogenous Tr…
Identifying immune mechanisms mediating the hypertension during preeclampsia Open
Preeclampsia (PE) is a pregnancy-associated disorder that affects 5–8% of pregnancies and is a major cause of maternal, fetal, and neonatal morbidity and mortality. Hallmark characteristics of PE are new onset hypertension after 20 wk gest…
The role of inflammation in the pathology of preeclampsia Open
Preeclampsia (PE) affects 5–7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity. PE is associated with hypertension after week 20 of gestation, decreased renal function and small-for-gesta…