Ashok Gupta
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View article: Assessment of Quality of Life in Acne Vulgaris Patients in Terms of Clinical Severity and Psychological Burden: A Multi Centre Study in Anand District
Assessment of Quality of Life in Acne Vulgaris Patients in Terms of Clinical Severity and Psychological Burden: A Multi Centre Study in Anand District Open
Background The term “acne” is derived from the Greek word “acme,” meaning “point” or “spot.” Acne vulgaris is one of the most common chronic dermatological conditions, predominantly caused by the Gram-positive anaerobic bacterium Cutibacte…
View article: Management of Benign Prostatic Hyperplasia with Overactive Bladder: Insights from Indian Clinical Practice
Management of Benign Prostatic Hyperplasia with Overactive Bladder: Insights from Indian Clinical Practice Open
Benign prostatic hyperplasia (BPH) and overactive bladder (OAB) frequently present with overlapping lower urinary tract symptoms (LUTS). The association between BPH and OAB-related storage symptoms remains a significant clinical concern. D…
View article: Bone tumours of the skull: Spectrum of 12 cases with review of literature at tertiary centre in Jaipur
Bone tumours of the skull: Spectrum of 12 cases with review of literature at tertiary centre in Jaipur Open
View article: Limb-Girdle Muscular Dystrophies (LGMD): Clinical features, diagnosis and genetic variability through next generation sequencing
Limb-Girdle Muscular Dystrophies (LGMD): Clinical features, diagnosis and genetic variability through next generation sequencing Open
View article: Sage and Rosemary Extract Gel: Anti-Aging Efficacy in D-galactose-Induced Skin Aging Model
Sage and Rosemary Extract Gel: Anti-Aging Efficacy in D-galactose-Induced Skin Aging Model Open
This study aimed to develop a topical herbal gel incorporating Salvia officinalis Linn and Rosmarinus officinalis L. extracts to evaluate its anti-aging effects in a mouse model of skin aging. Salvia officinalis and Rosmarinus officinalis …
View article: 8305 Assessing The Relationship Between Oral Health And Bone Disease Among Post-menopausal Women
8305 Assessing The Relationship Between Oral Health And Bone Disease Among Post-menopausal Women Open
Disclosure: N. Tahir: None. S. Ahmad: None. K. Batra: None. A. Gupta: None. K.E. Izuora: Research Investigator; Self; Novo Nordisk. Background: Menopause is associated with significant bone loss and worsening oral health, especially period…
View article: Assessment of visual function in patients with posterior fossa tumours
Assessment of visual function in patients with posterior fossa tumours Open
Introduction. Posterior fossa tumours (PFTs) frequently present with ophthalmic complaints. The literature is mainly focused on PFTs affecting the pediatric age group, and the post-treatment visual outcomes (VOs) are scarcely reported. Obj…
View article: RETRACTED: Assessment of Workplace Resilience in Reducing Burnout Among Postgraduates Across Multiple Medical Specialties
RETRACTED: Assessment of Workplace Resilience in Reducing Burnout Among Postgraduates Across Multiple Medical Specialties Open
The authors have requested that this preprint be removed from Research Square.
View article: RETRACTED: Assessment of Workplace Resilience in Reducing Burnout Among Postgraduates Across Multiple Medical Specialties
RETRACTED: Assessment of Workplace Resilience in Reducing Burnout Among Postgraduates Across Multiple Medical Specialties Open
The authors have requested that this preprint be removed from Research Square.
View article: Acute rhino-orbito-cerebral mucormycosis in a patient with uncontrolled type I diabetes mellitus: a case report
Acute rhino-orbito-cerebral mucormycosis in a patient with uncontrolled type I diabetes mellitus: a case report Open
Rhino-orbito-cerebral mucormycosis (ROCM) is a severe and often fatal fungal infection that primarily affects immunocompromised individuals, especially those with diabetes mellitus. The fungi, primarily Rhizopus oryzae, exhibit angio-invas…
View article: The potential and pitfalls of using a large language model such as ChatGPT, GPT-4, or LLaMA as a clinical assistant
The potential and pitfalls of using a large language model such as ChatGPT, GPT-4, or LLaMA as a clinical assistant Open
Objectives This study aims to evaluate the utility of large language models (LLMs) in healthcare, focusing on their applications in enhancing patient care through improved diagnostic, decision-making processes, and as ancillary tools for h…
View article: CONVERSION TO OPEN CHOLECYSTECTOMY - A SAFE ALTERNATIVE, NOT A FAILURE!
CONVERSION TO OPEN CHOLECYSTECTOMY - A SAFE ALTERNATIVE, NOT A FAILURE! Open
Background: Understanding factors that predict conversion in laparoscopic cholecystectomy (LC) to an open procedure is important as it allows better patient selection, preparation, operating list planning, referral, counseling and lowers t…
View article: JAUNDICE IN PATIENTS WITH GALL BLADDER CANCER- A SURROGATE MARKER OF ADVANCED DISEASE
JAUNDICE IN PATIENTS WITH GALL BLADDER CANCER- A SURROGATE MARKER OF ADVANCED DISEASE Open
Background: Gall bladder cancer (GBC) is most common cancer of biliary tract. R0 resection is the most important predictor of survival. Patients with GBC and jaundice do worse than those without jaundice.Methods: Retrospective analysis of …
View article: Investigation of women's plight in Madhu Kankariya's novel 'Sej Per Sanskrit'
Investigation of women's plight in Madhu Kankariya's novel 'Sej Per Sanskrit' Open
Women have such a close relationship with literature, art and philosophy that it is not possible to imagine civilization in its absence. In the Puranas and Sanskrit epics, women have been portrayed in a very dignified manner. In ancient In…
View article: Role of DTI (Diffuse Tensor Imaging) in Spinal Tumors: Prospective Observational Study
Role of DTI (Diffuse Tensor Imaging) in Spinal Tumors: Prospective Observational Study Open
Introduction: In management of spinal tumors, preoperative assessment of tumor type, predicting resectibility and postoperative outcomes is crucial for guiding treatment decisions and improving patient care.DTI has emerged as a valuable to…
View article: Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis
Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis Open
Ashok Kumar Gupta1, Reenu Yadav1*, Samisha Sharma1, Jyotiram Sawale1 and Ivan Kahwa2 Author informationArticle notesCopyright and License informationPDFCitations Corresponding author. Correspondence: Dr. Reenu Yadav1 IES Institute of Pharm…
View article: The Potential and Pitfalls of using a Large Language Model such as ChatGPT or GPT-4 as a Clinical Assistant
The Potential and Pitfalls of using a Large Language Model such as ChatGPT or GPT-4 as a Clinical Assistant Open
Recent studies have demonstrated promising performance of ChatGPT and GPT-4 on several medical domain tasks. However, none have assessed its performance using a large-scale real-world electronic health record database, nor have evaluated i…
View article: Supplementary Figure S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Antitumor efficacy of TNFRSF agonist immunotherapies in CT26 STK11wt or KO mice. Survival of mice engrafted with (A) CT26 WT or (B) CT26 STK11 KO clone 26C16 treated with isotype control antibodies, anti-PD-L1 plus anti-CTLA-4 mAbs or immu…
View article: Supplementary Figure S5 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S5 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Characterization of innate and adaptive immune cell recruitment to CT26 STK11 KO tumors compared to CT26 WT. (A) Work flow for single cell RNA (scRNA) analysis of CD45+ cells isolated from CT26 WT and STK11 KO clones. Data analysis includi…
View article: Supplementary Table S2 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Table S2 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
List of genes differentially expressed in STK11mut vs STK11wt tumors.
View article: Supplementary Figures 1 - 6 from Paradoxical Activation of T Cells via Augmented ERK Signaling Mediated by a RAF Inhibitor
Supplementary Figures 1 - 6 from Paradoxical Activation of T Cells via Augmented ERK Signaling Mediated by a RAF Inhibitor Open
PDF file - 528K, Supplementary Figure 1. BMS908662 enhances human T cell activation in vitro in a concentration-dependent manner. Supplementary Figure 2. BMS908662 inhibits the growth of BRAF mutant tumor cells in vitro. Supplementary Figu…
View article: Supplementary Figure S13 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S13 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Suppressive activity of MDSCs isolated from CT26 WT or CT26 SKT11 KO tumors and pharmacological reversal by STAT3 ASO treatment in the CT26 WT model. (A) Percentage of naive T cell proliferation by anti-CD3/CD28/IL2 stimulation in the pres…
View article: Data from Paradoxical Activation of T Cells via Augmented ERK Signaling Mediated by a RAF Inhibitor
Data from Paradoxical Activation of T Cells via Augmented ERK Signaling Mediated by a RAF Inhibitor Open
RAF inhibitors selectively block extracellular signal–regulated kinase (ERK) signaling in BRAF-mutant melanomas and have defined a genotype-guided approach to care for this disease. RAF inhibitors have the opposite effect in BRAF wild-type…
View article: Supplementary Table S5 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Table S5 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Marker genes for the monocyte-macrophage-DC subpopulations identified in Supplementary Figure 5H. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on …
View article: Supplementary Figure S11 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S11 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Efficacy of anti-IL6 mAb in CT26 STK11 KO model. (A) Survival of mice engrafted with 26C16 and treated as indicated. Isotype vs anti-PD-L1 plus anti-CTLA-4, p = 0.0020; Isotype vs anti-IL6 plus anti-PD-L1 plus anti-CTLA-4, p = 0.034; anti-…
View article: Supplementary Figure S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Characterization of STAT3 phosphorylation in the CT26 STK11 KO model and from primary human NSCLC tumors. (A) Representative multispectral fluorescence imaging of phosphorylated murine STAT3 (pSTAT3), CD45, CD163, and nuclei (DAPI), as ind…
View article: Supplementary Table S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Table S8 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Kaplan-Meier analysis using a log rank (Mantel-Cox) test to compare survival among the treatment groups represented in Figure 5. A total of 9 comparisons between groups were conducted. P-values were not adjusted for multiple comparisons.
View article: Supplementary Table S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Table S7 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Time to 50% survival, in days, for mice engrafted with EMT6 tumors left untreated or treated with isotype control Ab or anti-PD-L1 plus anti-CTLA-4.
View article: Supplementary Figure S14 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S14 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
Dependence of STAT3 ASO and combination treatment efficacy on CD8+ or CD4+ T cells in CT26 STK11 KO clone 26C16. Efficacy of STAT3 ASO, CPIs, and combination treatments as indicated in mice pre-treated with (A) control antibody, (B) anti-C…
View article: Supplementary Figure S9 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown
Supplementary Figure S9 from Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional <i>STK11</i> Mutations in Patients with Non–Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown Open
CPI efficacy in EMT6 STK11wt, KO, and KO/KI tumors. (A) Western blotting of STK11, phosphorylated AMPK (p-AMPK), total AMPK, and actin in lysates from wild-type EMT6 cells (EMT6 WT), STK11 CRISPR KO clone (EMT6 KO) and from STK11 KO clone …