Ashok Iyaswamy
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View article: Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases
Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases Open
Introduction Aging is a normal process causing deterioration in normal brain function and is inevitable. The aging process is described by the buildup of senescent cells and a decline in the ability to maintain essential homeostatic functi…
View article: MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity Open
View article: Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease
Licochalcone A selectively modulates mTORC1‐TFEB to enhance autophagy and demonstrates neuroprotective effects in a mouse model of Parkinson's disease Open
Activation of transcription factor EB (TFEB), a key regulator of autophagy induction and lysosomal biogenesis, is considered a promising therapeutic strategy for treating the currently incurable Parkinson's disease (PD). However, most TFEB…
View article: Single-cell transcriptomic insights into endosulfan-induced liver injury: Key pathways and inflammatory responses
Single-cell transcriptomic insights into endosulfan-induced liver injury: Key pathways and inflammatory responses Open
This study provides new insights into the cellular and molecular mechanisms underlying liver injury induced by organochlorine insecticides like ENDO. Key genes and pathways involved in ENDO-associated liver toxicity have been identified at…
View article: Evaluation of water quality parameters in ornamental fish silver moony, Monodactylus argenteus (Linnaeus, 1758)
Evaluation of water quality parameters in ornamental fish silver moony, Monodactylus argenteus (Linnaeus, 1758) Open
View article: Role of <i>Candida</i> species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease
Role of <i>Candida</i> species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn's disease Open
The gut microbiome plays a key role in the pathogenesis and disease activity of inflammatory bowel disease (IBD). While research has focused on the bacterial microbiome, recent studies have shifted towards host genetics and host-fungal int…
View article: Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer’s disease
Unraveling the interplay of kinesin-1, tau, and microtubules in neurodegeneration associated with Alzheimer’s disease Open
Alzheimer’s disease (AD) is marked by the gradual and age-related deterioration of nerve cells in the central nervous system. The histopathological features observed in the brain affected by AD are the aberrant buildup of extracellular and…
View article: Peptide-Conjugated Vascular Endothelial Extracellular Vesicles Encapsulating Vinorelbine for Lung Cancer Targeted Therapeutics
Peptide-Conjugated Vascular Endothelial Extracellular Vesicles Encapsulating Vinorelbine for Lung Cancer Targeted Therapeutics Open
Lung cancer is one of the major cancer types and poses challenges in its treatment, including lack of specificity and harm to healthy cells. Nanoparticle-based drug delivery systems (NDDSs) show promise in overcoming these challenges. Whil…
View article: Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout: Insights and therapeutic strategies
Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout: Insights and therapeutic strategies Open
Hyperuricemia (HUA) is a condition associated with a high concentration of uric acid (UA) in the bloodstream and can cause gout and chronic kidney disease. The gut microbiota of patients with gout and HUA is significantly altered compared …
View article: Peroxisome proliferator-activated receptor agonists: A new hope towards the management of alcoholic liver disease
Peroxisome proliferator-activated receptor agonists: A new hope towards the management of alcoholic liver disease Open
In this editorial, we examine a paper by Koizumi et al , on the role of peroxisome proliferator-activated receptor (PPAR) agonists in alcoholic liver disease (ALD). The study determined whether elafibranor protected the intestinal barrier …
View article: Aspartame Causes Developmental Defects and Teratogenicity in Zebra Fish Embryo: Role of Impaired SIRT1/FOXO3a Axis in Neuron Cells
Aspartame Causes Developmental Defects and Teratogenicity in Zebra Fish Embryo: Role of Impaired SIRT1/FOXO3a Axis in Neuron Cells Open
Aspartame, a widely used artificial sweetener, is present in many food products and beverages worldwide. It has been linked to potential neurotoxicity and developmental defects. However, its teratogenic effect on embryonic development and …
View article: Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models Open
View article: Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease
Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease Open
Aβ specific theranostic small molecule, F-SLCOOH inhibits Aβ self-aggregation and promotes lysosomal biogenesis in Alzheimer’s disease models.
View article: Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation
Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation Open
Natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as Alzheimer’s disease (AD), tau aggregates into paired helical filaments (PHFs) and neurofibrillary tangles (NFTs). Multiple intracellular transport p…
View article: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease Open
View article: Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics
Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics Open
Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies…
View article: Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and its Therapeutics
Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and its Therapeutics Open
Bacterial Extracellular Vesicles (BEVs) generated from the bacteria has high feasibility of intracellular interactions with other cells, can be used as a cargo to deliver any therapeutic substances like monoclonal antibodies, proteins, pla…
View article: Corrigendum to “Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review” [ Biomed. Pharamacother. 133, (2021) 110968]
Corrigendum to “Traditional Chinese medicine compounds regulate autophagy for treating neurodegenerative disease: A mechanism review” [ Biomed. Pharamacother. 133, (2021) 110968] Open
View article: Delivery of Apoplastic Extracellular Vesicles Encapsulating Green-Synthesized Silver Nanoparticles to Treat Citrus Canker
Delivery of Apoplastic Extracellular Vesicles Encapsulating Green-Synthesized Silver Nanoparticles to Treat Citrus Canker Open
The citrus canker pathogen Xanthomonas axonopodis has caused severe damage to citrus crops worldwide, resulting in significant economic losses for the citrus industry. To address this, a green synthesis method was used to develop silver na…
View article: Editorial: Advances in Alzheimer’s disease diagnostics, brain delivery systems, and therapeutics
Editorial: Advances in Alzheimer’s disease diagnostics, brain delivery systems, and therapeutics Open
EDITORIAL article Front. Mol. Biosci., 17 March 2023Sec. Molecular Diagnostics and Therapeutics Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1162879
View article: Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s Disease
Novel Insight into Functions of Transcription Factor EB (TFEB) in Alzheimer’s Disease and Parkinson’s Disease Open
A key pathological feature of neurodegenerative diseases (NDs) such as Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of aggregated and misfolded protein aggregates with limited effective therapeutic agents. TFEB…
View article: Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy
Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer’s disease therapy Open
Emerging evidence from Alzheimer’s disease (AD) patients suggests that reducing tau pathology can restore cognitive and memory loss. To reduce tau pathology, it is critical to find brain-permeable tau-degrading small molecules that are saf…
View article: Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models
Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer’s disease and tauopathy models Open
Many neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17, are characterized by tau pathology. Numerous motor proteins, many of which are involved in synaptic tr…
View article: The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review
The epigenetic correlation among ovarian cancer, endometriosis and PCOS: A review Open
Ovarian cancer is a frequent malignancy that affects a large percentage of women. Endometriosis is a chronic condition, where there is a production of benign lesions were observed in the uterine environment. PCOS is a metabolic disorder ch…
View article: Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies
Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies Open
Background Tauopathies are neurodegenerative diseases that are associated with the pathological accumulation of tau-containing tangles in the brain. Tauopathy can impair cognitive and motor functions and has been observed in Alzheimer’s di…
View article: Pleiotropic effects of DCLK1 in cancer and cancer stem cells
Pleiotropic effects of DCLK1 in cancer and cancer stem cells Open
Doublecortin-like kinase 1 (DCLK1), a protein molecule, has been identified as a tumor stem cell marker in the cancer cells of gastrointestinal, pancreas, and human colon. DCLK1 expression in cancers, such as breast carcinoma, lung carcino…
View article: Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease
Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer’s Disease Open
Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by aggregated amyloid-β (Aβ) in Alzheimer's disease (AD). Tools that c…
View article: Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease
Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer’s Disease Open
Eukaryotic cells possess a plethora of regulatory mechanisms to maintain homeostasis and ensure proper biochemical functionality. Autophagy, a central, conserved self-consuming process of the cell, ensures the timely degradation of damaged…
View article: Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review
Klotho an Autophagy Stimulator as a Potential Therapeutic Target for Alzheimer’s Disease: A Review Open
Alzheimer’s disease (AD) is an age-associated neurodegenerative disease; it is the most common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily generated in the brain and kidney, is active in a variety of met…
View article: Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models
Theranostic F-SLOH mitigates Alzheimer's disease pathology involving TFEB and ameliorates cognitive functions in Alzheimer's disease models Open