Ashok Pullikuth
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View article: The Genomic Topography of Appendiceal Cancers: Our Current Understanding, Clinical Perspectives, and Future Directions
The Genomic Topography of Appendiceal Cancers: Our Current Understanding, Clinical Perspectives, and Future Directions Open
Background/Objectives: Appendiceal cancer (AC) is a rare and understudied malignancy with limited genomic data available to guide clinical interventions. Historically treated as a subtype of colorectal cancer, AC is now recognized as a dis…
View article: A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers
A patient stratification signature mirrors the immunogenic potential of high grade serous ovarian cancers Open
View article: Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment
Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment Open
View article: Supplementary Figure S5 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S5 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
IPA network schematics of regulatory pathways identified by IBE-IBD differentially expressed genes.
View article: Supplementary Figure S4 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S4 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Subgroup analysis in IBE and IBD tumors. Kaplan-Meier plots comparing the probability of DMFS of patients classified as FID, WID and PID.
View article: Supplementary Figure S3 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S3 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Differential abundance of immune cell infiltrate in FID and PID breast tumors.
View article: Data from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Data from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
The abundance and functional orientation of tumor-infiltrating lymphocytes in breast cancer is associated with distant metastasis-free survival, yet how this association is influenced by tumor phenotypic heterogeneity is poorly understood.…
View article: Supplementary Figure S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Cross-cohort comparisons of metagene distributions and tertile thresholds.
View article: Supplementary Figure S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Cross-cohort comparisons of metagene distributions and tertile thresholds.
View article: Supplementary Figure S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
The B/P, T/NK and M/D immune metagenes are coordinately expressed in breast tumors and leukocytes but not in breast cancer cell lines.
View article: Supplementary Figure S5 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S5 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
IPA network schematics of regulatory pathways identified by IBE-IBD differentially expressed genes.
View article: Data from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Data from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
The abundance and functional orientation of tumor-infiltrating lymphocytes in breast cancer is associated with distant metastasis-free survival, yet how this association is influenced by tumor phenotypic heterogeneity is poorly understood.…
View article: Supplementary Table S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Table S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Assessment of the prognostic significance of the IMM as a function of intrinsic subtype and proliferation tertile.
View article: Supplementary Methods from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Methods from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Detailed description of methods.
View article: Supplementary Methods from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Methods from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Detailed description of methods.
View article: Data from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1
Data from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1 Open
There is accumulating evidence that continuous activation of the sympathetic nervous system due to psychosocial stress increases resistance to therapy and accelerates tumor growth via β2-adrenoreceptor signaling (ADRB2). However, the effec…
View article: Supplementary Table S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Table S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Clinical characteristics of the breast cancer cohorts.
View article: Supplementary Figure S4 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S4 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Subgroup analysis in IBE and IBD tumors. Kaplan-Meier plots comparing the probability of DMFS of patients classified as FID, WID and PID.
View article: Supplementary Table S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Table S2 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Assessment of the prognostic significance of the IMM as a function of intrinsic subtype and proliferation tertile.
View article: Supplementary Table S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Table S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Clinical characteristics of the breast cancer cohorts.
View article: Supplementary Figures 1-5 from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1
Supplementary Figures 1-5 from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1 Open
S1. Epinephrine inhibits apoptosis by upregulatingMCL1in prostate cancer cells. S2.Epinephrine upregulates MCL1via the ADRB2/PKA pathway S3.C4-2shMCL1 cells with inducible expression of shRNAtargeting MCL1. S4. Effects of chemotherapy drug…
View article: Supplementary Figures 1-5 from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1
Supplementary Figures 1-5 from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1 Open
S1. Epinephrine inhibits apoptosis by upregulatingMCL1in prostate cancer cells. S2.Epinephrine upregulates MCL1via the ADRB2/PKA pathway S3.C4-2shMCL1 cells with inducible expression of shRNAtargeting MCL1. S4. Effects of chemotherapy drug…
View article: Supplementary Figure S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S1 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
The B/P, T/NK and M/D immune metagenes are coordinately expressed in breast tumors and leukocytes but not in breast cancer cell lines.
View article: Data from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1
Data from β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1 Open
There is accumulating evidence that continuous activation of the sympathetic nervous system due to psychosocial stress increases resistance to therapy and accelerates tumor growth via β2-adrenoreceptor signaling (ADRB2). However, the effec…
View article: Supplementary Figure S3 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness
Supplementary Figure S3 from Immunogenic Subtypes of Breast Cancer Delineated by Gene Classifiers of Immune Responsiveness Open
Differential abundance of immune cell infiltrate in FID and PID breast tumors.
View article: Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes
Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes Open
Background Triggering receptor expressed on myeloid cells (TREM)-1 is a key mediator of innate immunity previously associated with the severity of inflammatory disorders, and more recently, the inferior survival of lung and liver cancer pa…
View article: β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1
β2-adrenoreceptor Signaling Increases Therapy Resistance in Prostate Cancer by Upregulating MCL1 Open
There is accumulating evidence that continuous activation of the sympathetic nervous system due to psychosocial stress increases resistance to therapy and accelerates tumor growth via β2-adrenoreceptor signaling (ADRB2). However, the effec…
View article: Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types
Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types Open
Background: Understanding how tumors subvert immune destruction is essential to the development of cancer immunotherapies. New evidence suggests that tumors limit anti-tumor immunity by exploiting transcriptional programs that regulate int…
View article: Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq
Dissecting intratumoral myeloid cell plasticity by single cell RNA‐seq Open
Tumor‐infiltrating myeloid cells are the most abundant leukocyte population within tumors. Molecular cues from the tumor microenvironment promote the differentiation of immature myeloid cells toward an immunosuppressive phenotype. However,…
View article: Tumor mutational burden is a determinant of immune-mediated survival in breast cancer
Tumor mutational burden is a determinant of immune-mediated survival in breast cancer Open
Mounting evidence supports a role for the immune system in breast cancer outcomes. The ability to distinguish highly immunogenic tumors susceptible to anti-tumor immunity from weakly immunogenic or inherently immune-resistant tumors would …