Ashraf A. Sediek
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View article: Synthesis, molecular docking, ADMET studies and biological evaluation of fused pyrazolopyridopyrimidine derivatives as antioxidant and antimicrobial agents
Synthesis, molecular docking, ADMET studies and biological evaluation of fused pyrazolopyridopyrimidine derivatives as antioxidant and antimicrobial agents Open
This study describes the design, synthesis, and biological evaluation of fused pyrazolopyridopyrimidine analogues as potential antimicrobial and antioxidant agents. The chemical structures of the newly synthesized compounds were confirmed …
View article: Synthesis, Biological Evaluation, and Molecular Docking Studies of Indole‐Based Heterocyclic Scaffolds as Potential Antibacterial Agents
Synthesis, Biological Evaluation, and Molecular Docking Studies of Indole‐Based Heterocyclic Scaffolds as Potential Antibacterial Agents Open
Indole‐based heterocyclic scaffolds have become increasingly important in medicinal chemistry due to their notable pharmacological and biological properties. Their role in the discovery and development of innovative drugs for treating vari…
View article: Antimicrobial and Molecular Docking Studies of 1,3,4-Thiadiazole Tethered Sulfa-Azo Derivatives <i>via</i> Hydrazono-Methyl Bridge
Antimicrobial and Molecular Docking Studies of 1,3,4-Thiadiazole Tethered Sulfa-Azo Derivatives <i>via</i> Hydrazono-Methyl Bridge Open
A new series of 1,3,4-thiadiazole linked to sulfa-azo derivatives via hydrazono-methyl bridge were synthesized via the reaction of methyl ((E)-(sulfa-derivatives)diazenyl) benzylidene)hydrazine-1-carbodithioates 1a-e with ethyl ester and a…
View article: Synthesis, Characterization and Antitumor Activity of Benzimidazole Phosphonate Derivatives
Synthesis, Characterization and Antitumor Activity of Benzimidazole Phosphonate Derivatives Open
A series of Benzimidazole derivatives were obtained via reaction of 2-chloro-1H-benzo[d]imidazole (1) with morpholine, which produce benzo[d]imidazol-yl-morpholine 2 that react with chloroacetonitrile to give (benzo[d]imidazol-yl)acetonitr…
View article: Design, synthesis and <i>in vitro</i> anti-proliferative evaluation of new pyridine-2,3-dihydrothiazole/thiazolidin-4-one hybrids as dual CDK2/GSK3β kinase inhibitors
Design, synthesis and <i>in vitro</i> anti-proliferative evaluation of new pyridine-2,3-dihydrothiazole/thiazolidin-4-one hybrids as dual CDK2/GSK3β kinase inhibitors Open
Hybridization of pyridine with 2,3-dihydrothiazole or thiazolidin-4-one by ethylidenehydrazono spacer was crucial for dual CDK2/GSK3β inhibitory activity and good antiproliferative activity. The most potent compound 13a can act as promisin…
View article: Novel Pyrazolines and Benzothiazepines as Tubulin Polymerization Inhibitors: Synthesis, Biological Evaluation, and Molecular Docking
Novel Pyrazolines and Benzothiazepines as Tubulin Polymerization Inhibitors: Synthesis, Biological Evaluation, and Molecular Docking Open
Synthesis, biological evaluation, and molecular docking of pyrazoline-linked benzenesulfonamides and diaryl 1,5-benzothiazepines prepared from new chalcones are described and elucidated.Novel compounds were studied for their in vitro antic…