Ashraf B. Abdel‐Naim
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View article: Galangin Mitigates Letrozole-Induced Polycystic Ovary Syndrome in Rats by Restoring PI3K/pAKT/PTEN Signaling
Galangin Mitigates Letrozole-Induced Polycystic Ovary Syndrome in Rats by Restoring PI3K/pAKT/PTEN Signaling Open
Purpose: Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder characterized by hyperandrogenism, ovulatory dysfunction, and the formation of ovarian cysts. Key contributors to its pathophysiology include oxidative…
View article: Piceatannol and Pumpkin Seed Oil Synergistically Promote Apoptosis of PC3 Prostate Cancer Cells via Intrinsic Mitochondrial Pathway
Piceatannol and Pumpkin Seed Oil Synergistically Promote Apoptosis of PC3 Prostate Cancer Cells via Intrinsic Mitochondrial Pathway Open
Purpose: Piceatannol (PIC) is a polyphenolic stilbene that occurs naturally in various fruits and vegetables. Despite its well-documented anticancer activity, PIC has poor pharmacokinetic properties. Pumpkin seed oil (PSO) has well-…
View article: Retraction Note: Intensification of resveratrol cytotoxicity, pro-apoptosis, oxidant potentials in human colorectal carcinoma HCT-116 cells using zein nanoparticles
Retraction Note: Intensification of resveratrol cytotoxicity, pro-apoptosis, oxidant potentials in human colorectal carcinoma HCT-116 cells using zein nanoparticles Open
View article: Alantolactone mitigates thioacetamide-induced liver fibrosis in mice by inhibiting TLR4/MyD88/NF-κB axis
Alantolactone mitigates thioacetamide-induced liver fibrosis in mice by inhibiting TLR4/MyD88/NF-κB axis Open
Objective: To explore the effect of alantolactone on thioacetamide-induced liver fibrosis in mice as well as elucidate its underlying mechanism. Methods: Animals were divided into 5 groups: the control, the thioacetamide group (150 mg/kg/t…
View article: Red yeast rice expedites wound healing in diabetic rats: emphasis on its pro-collagen and angiogenic activities
Red yeast rice expedites wound healing in diabetic rats: emphasis on its pro-collagen and angiogenic activities Open
Delayed wound healing is a challenge, especially in patients with diabetes mellitus. Red yeast rice (RYR) is a traditional medicine with known uses in several ailments including stasis of blood and weakness of limbs. Experimentally, it was…
View article: RETRACTED: Alhakamy et al. Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells. Int. J. Mol. Sci. 2019, 20, 5788
RETRACTED: Alhakamy et al. Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells. Int. J. Mol. Sci. 2019, 20, 5788 Open
The journal retracts the article titled “Encapsulation of Lovastatin in Zein Nanoparticles Exhibits Enhanced Apoptotic Activity in HepG2 Cells” [...]
View article: Glatiramer–diclofenac nanocomplex enhances remyelination in a mouse model of multiple sclerosis
Glatiramer–diclofenac nanocomplex enhances remyelination in a mouse model of multiple sclerosis Open
Background The hallmark of multiple sclerosis (MS) is neuronal demyelination. Glatiramer acetate (GA) injection is used in the management of MS. Nevertheless, it suffers unacceptable adverse reactions. Alternatively, nose-to-brain drug del…
View article: Molecular docking, antimicrobial, antibiofilm formation, and antiproliferative activities of furano-based sesquiterpenoids from Euryops arabicus
Molecular docking, antimicrobial, antibiofilm formation, and antiproliferative activities of furano-based sesquiterpenoids from Euryops arabicus Open
Background Euryops arabicus is well known in the Arabian Peninsula as traditional herbal medicine. The plant synthesizes various types of flavonoids, terpenes, and furoermophilanes skeletons in either steroidal or nonsteroidal conformation…
View article: Icariin zeinmersomes display enhanced anti-proliferative and pro-apoptotic activities in colon cancer cells
Icariin zeinmersomes display enhanced anti-proliferative and pro-apoptotic activities in colon cancer cells Open
Background The present study aimed at investigating the effectiveness of zeinmersomes (ZMS)-based nano-formulation to enhance icariin (ICA) cytotoxicity in colon cancer cells. The prepared ICA-ZMS was characterized with respect to particle…
View article: RETRACTED: Al-Wahaibi et al. Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells. Int. J. Mol. Sci. 2020, 21, 4138
RETRACTED: Al-Wahaibi et al. Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells. Int. J. Mol. Sci. 2020, 21, 4138 Open
The journal retracts the article titled “Optimized Conjugation of Fluvastatin to HIV-1 TAT Displays Enhanced Pro-Apoptotic Activity in HepG2 Cells” [...]
View article: Anti-Inflammatory Humulene-Type Sesquiterpenoids from Asteriscus Graveolens
Anti-Inflammatory Humulene-Type Sesquiterpenoids from Asteriscus Graveolens Open
Objectives: Inflammation is the initial physiological reaction of the immune system to infection or irritation, leading significant risk factors for several forms of cancer. The genus Asteriscus has been observed to possess a notable abund…
View article: α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells
α-Mangostin-phytosomes as a plausible nano-vesicular approach for enhancing cytotoxic activity on SKOV-3 ovarian cancer cells Open
Background α -Mangostin is a major xanthone in Garcinia mangostana L. (Clusiaceae) pericarps. It has promising anti-proliferative potential in different cancer cells; however, it has poor oral bioavailability. Phytosomes are used as a nove…
View article: RETRACTED: Alhakamy et al. Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats. Pharmaceutics 2021, 13, 1622
RETRACTED: Alhakamy et al. Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats. Pharmaceutics 2021, 13, 1622 Open
The journal retracts the article, “Ceftriaxone and Melittin Synergistically Promote Wound Healing in Diabetic Rats” [...]
View article: Cordycepin alleviates endometrial hyperplasia in rats via alteration of PTEN/PI3K/Akt axis
Cordycepin alleviates endometrial hyperplasia in rats via alteration of PTEN/PI3K/Akt axis Open
Endometrial hyperplasia (EH) is a reproductive health concern distinguished by unusual thickening of the uterine lining. Cordycepin (COR) is a bioactive substance with favorable antioxidant and anti-inflammatory properties. This study soug…
View article: Diuretic effects of Hecogenin and Hecogenin acetate via aldosterone synthase inhibition
Diuretic effects of Hecogenin and Hecogenin acetate via aldosterone synthase inhibition Open
Hecogenin (HEC) is a steroidal saponin found in many plant species and serves as a precursor for steroidal drugs. The diuretic effects of HEC and its derivative, hecogenin acetate (HA), remain largely unexplored. The present study aimed to…
View article: Correction: Nasrullah et al. Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys. Pharmaceuticals 2022, 15, 782
Correction: Nasrullah et al. Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys. Pharmaceuticals 2022, 15, 782 Open
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View article: Computational insights into dynamics and conformational stability of N-acetylmannosamine kinase mutations
Computational insights into dynamics and conformational stability of N-acetylmannosamine kinase mutations Open
The activity of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is essential for the biosynthesis of sialic acid, which is involved in cellular processes in health and diseases. GNE contains an N-terminal epimerase domain and a C-terminal kinas…
View article: RETRACTED: Alhakamy et al. Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity. Pharmaceutics 2020, 12, 652
RETRACTED: Alhakamy et al. Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity. Pharmaceutics 2020, 12, 652 Open
The journal retracts the article “Chitosan-Based Microparticles Enhance Ellagic Acid’s Colon Targeting and Proapoptotic Activity” [...]
View article: RETRACTED: Alhakamy et al. Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells. Pharmaceutics 2020, 12, 346
RETRACTED: Alhakamy et al. Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells. Pharmaceutics 2020, 12, 346 Open
The journal retracts the article, “Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells” [...]
View article: Berberine alleviates chlorpyrifos-induced nephrotoxicity in rats via modulation of Nrf2/HO-1 axis
Berberine alleviates chlorpyrifos-induced nephrotoxicity in rats via modulation of Nrf2/HO-1 axis Open
View article: RETRACTED: Alhakamy et al. Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment. Pharmaceutics 2022, 14, 1133
RETRACTED: Alhakamy et al. Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment. Pharmaceutics 2022, 14, 1133 Open
The journal retracts the article, “Fluoxetine Ecofriendly Nanoemulsion Enhances Wound Healing in Diabetic Rats: In Vivo Efficacy Assessment” [...]
View article: RETRACTED: Asfour et al. Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats. Pharmaceutics 2022, 14, 1792
RETRACTED: Asfour et al. Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats. Pharmaceutics 2022, 14, 1792 Open
Pharmaceutics retracted the article “Amitriptyline-Based Biodegradable PEG-PLGA Self-Assembled Nanoparticles Accelerate Cutaneous Wound Healing in Diabetic Rats” [...]
View article: Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells
Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells Open
Costunolide (COST) is a sesquiterpene lactone that belongs to the germacranolide group, and occurs mainly in Saussurea lappa Clarke. Although COST inhibits the proliferation and metastasis of cancer cells and induces their apoptosis, it su…
View article: LC-MS based metabolic profiling and wound healing activity of a chitosan nanoparticle-loaded formula of Teucrium polium in diabetic rats
LC-MS based metabolic profiling and wound healing activity of a chitosan nanoparticle-loaded formula of Teucrium polium in diabetic rats Open
Healing of wounds is the most deteriorating diabetic experience. Felty germander (Teucrium polium) possesses antioxidant, anti-inflammatory and antimicrobial activities that could accelerate wound healing. Further, nanohydrogels help quick…
View article: Taif Rose Oil Ameliorates UVB-Induced Oxidative Damage and Skin Photoaging in Rats via Modulation of MAPK and MMP Signaling Pathways
Taif Rose Oil Ameliorates UVB-Induced Oxidative Damage and Skin Photoaging in Rats via Modulation of MAPK and MMP Signaling Pathways Open
Short-wave UVB (ultraviolet B) causes rapid oxidative damage to the skin. Rose water is obtained mainly from the petals of Rosa damascena Mill. (Rosaceae) and used traditionally to hydrate dry skin and reduce signs of aging. This wo…
View article: Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis
Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis Open
Chlorpyrifos (CPF), is an organophosphate pesticide that is widely used for agricultural purposes. However, it has well-documented hepatotoxicity. Lycopene (LCP) is a plant-derived carotenoid with antioxidant and anti-inflammatory activiti…
View article: Correction: Al-Qahtani et al. Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells. Life 2022, 12, 1369
Correction: Al-Qahtani et al. Self-Nanoemulsifying Drug Delivery System of 2-Methoxyestradiol Exhibits Enhanced Anti-Proliferative and Pro-Apoptotic Activities in MCF-7 Breast Cancer Cells. Life 2022, 12, 1369 Open
In the original publication [...]
View article: Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats
Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats Open
Metabolic syndrome (MetS) is a combination of metabolic disorders that can predispose individuals to benign prostatic hyperplasia (BPH). The inhibition of the cannabinoid 1 (CB1) receptor has been used to treat metabolic disorders in anima…
View article: Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats
Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats Open
View article: Berberine Alleviates Chlorpyrifos-Induced Nephrotoxicity in Rats via Modulation of Nrf2/HO-1 Axis
Berberine Alleviates Chlorpyrifos-Induced Nephrotoxicity in Rats via Modulation of Nrf2/HO-1 Axis Open