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View article: Professor Marc Henry (1958-2024)
Professor Marc Henry (1958-2024) Open
Professor Marc Henry passed away on November 2024 aged 66 after a long fight against cardio-vascular disease. His academic career focused on the physical nature of water. This is of particular importance in the chemistry of gel-sol compoun…
View article: Metabolic modelling links Warburg effect to collagen formation, angiogenesis and inflammation in the tumoral stroma
Metabolic modelling links Warburg effect to collagen formation, angiogenesis and inflammation in the tumoral stroma Open
Cancer cells are known to express the Warburg effect—increased glycolysis and formation of lactic acid even in the presence of oxygen—as well as high glutamine uptake. In tumors, cancer cells are surrounded by collagen, immune cells, and n…
View article: Metabolic Shift and Hyperosmolarity Underlie Age-Related Macular Degeneration
Metabolic Shift and Hyperosmolarity Underlie Age-Related Macular Degeneration Open
Age-related macular degeneration (AMD) is both a poorly understood and devastating disease. Here, we analyze the physico-chemical forces at stake, including osmolarity, redox shift, and pressure due to inflammation. Hyperosmolarity plays a…
View article: Metabolic Shift and Increased Osmotic Pressure Underlie Age-Related Macular Degeneration: A Review
Metabolic Shift and Increased Osmotic Pressure Underlie Age-Related Macular Degeneration: A Review Open
In our previous papers, we demonstrated that inflammation and aging are the common roots of cancer and Alzheimer’s disease (AD). In both diseases, there is an inhibition of the mitochondria. In cancer, the alkaline intracellular pH (…
View article: Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2)
Green-Synthesized Silver and Selenium Nanoparticles Using Berberine: A Comparative Assessment of In Vitro Anticancer Potential on Human Hepatocellular Carcinoma Cell Line (HepG2) Open
A well-known natural ingredient found in several medicinal plants, berberine (Ber), has been shown to have anticancer properties against a range of malignancies. The limited solubility and bioavailability of berberine can be addressed usin…
View article: From electrons to cancer : Redox shift as a driving force of tumorigenesis
From electrons to cancer : Redox shift as a driving force of tumorigenesis Open
International audience
View article: Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells Open
Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
View article: Data from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
Data from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells Open
The tumor cell–derived hyaluronidase (HAase) HYAL-1 degrades hyaluronic acid (HA) into proangiogenic fragments that support tumor progression. Although HYAL-1 is a critical determinant of tumor progression and a marker for cancer diagnosis…
View article: Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells Open
Supplementary Methods, Tables 1-3, Figures 1-6 from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
View article: Data from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells
Data from Targeting Hyaluronidase for Cancer Therapy: Antitumor Activity of Sulfated Hyaluronic Acid in Prostate Cancer Cells Open
The tumor cell–derived hyaluronidase (HAase) HYAL-1 degrades hyaluronic acid (HA) into proangiogenic fragments that support tumor progression. Although HYAL-1 is a critical determinant of tumor progression and a marker for cancer diagnosis…
View article: <i>Pergularia tomentosa</i> coupled with selenium nanoparticles salvaged lead acetate-induced redox imbalance, inflammation, apoptosis, and disruption of neurotransmission in rats’ brain
<i>Pergularia tomentosa</i> coupled with selenium nanoparticles salvaged lead acetate-induced redox imbalance, inflammation, apoptosis, and disruption of neurotransmission in rats’ brain Open
In this study, the neuroprotective potential of either Pergularia tomentosa leaf methanolic extract (PtE) alone or in combination with selenium nanoparticles (SeNPs-PtE) was investigated against lead acetate (PbAc)-induced neurotoxicity. E…
View article: RETRACTED: Strigol1/albumin/chitosan nanoparticles decrease cell viability, induce apoptosis and alter metabolomics profile in HepG2 cancer cell line
RETRACTED: Strigol1/albumin/chitosan nanoparticles decrease cell viability, induce apoptosis and alter metabolomics profile in HepG2 cancer cell line Open
Hepatocellular carcinoma is one of the most common causes of cancer-related deaths globally. Bioavailable, effective and safe therapeutic agents are urgently needed for cancer treatment. This study evaluated the metabolomics profiling, ant…
View article: Green <i>Coffea arabica</i> Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats
Green <i>Coffea arabica</i> Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats Open
Diabetes mellitus (DM) is a chronic endocrine disease characterized by persistent hyperglycemia. Oxidative damage, inflammatory cytokines, and apoptotic cell death play a major role in the induction and progression of male testicular damag…
View article: Aberrant Overexpression of Heterogeneous Nuclear Ribonucleoprotein k in Urinary Bladder Cancer Neoplasms
Aberrant Overexpression of Heterogeneous Nuclear Ribonucleoprotein k in Urinary Bladder Cancer Neoplasms Open
Bladder cancer remains one of the most prevalent cancers and is considered to be one of the primary causes of morbidity and mortality worldwide. Nonetheless, the treatment and management of this malignancy can be very prosperous only if di…