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View article: Supplementary Table S4 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Table S4 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Epigenetically inactivated, upregulated, downregulated and differentially expressed genes.
View article: Supplementary Table S3 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Table S3 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Somatic mutations identified by WES.
View article: Data from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Data from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and col…
View article: Supplementary Table S3 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Table S3 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Somatic mutations identified by WES.
View article: Supplementary Table S4 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Table S4 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Epigenetically inactivated, upregulated, downregulated and differentially expressed genes.
View article: Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supp…
View article: Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Supplementary Methods, Figures 1-6 Supplemental Tables 1-2 from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supp…
View article: Data from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors
Data from Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors Open
Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and col…
View article: Surgical decompression for malignant cerebral oedema after ischaemic stroke
Surgical decompression for malignant cerebral oedema after ischaemic stroke Open
Surgical decompression improves outcomes in the management of malignant oedema after acute ischaemic stroke, including a considerable reduction in death or severe disability (mRS > 4) and a reduction in death or moderate disability (mRS > …
View article: Donut sign: a unique radiological sign of cerebral metastasis in malignant mesothelioma
Donut sign: a unique radiological sign of cerebral metastasis in malignant mesothelioma Open
A man in his 70s presented to the emergency department with a 3-day history of confusion and right-facial droop. He was diagnosed with stage IIIB (T4N2M0) malignant mesothelioma 6 months previously for which he was being given palliative c…
View article: Pseudochoreoathetosis secondary to progressive spondylotic cervical myelopathy
Pseudochoreoathetosis secondary to progressive spondylotic cervical myelopathy Open
Pseudochoreoathetosis is a rare movement disorder associated with loss of proprioception. Culprit lesions may occur at any point between the cerebral cortex and the peripheral nerve. Seldom is the underlying cause reversible or prone to im…
View article: Traumatic intracranial nail-gun injury of the right internal carotid artery causing pseudoaneurysm and caroticocavernous fistula
Traumatic intracranial nail-gun injury of the right internal carotid artery causing pseudoaneurysm and caroticocavernous fistula Open
Penetrating trauma due to nail gun is an uncommon yet important clinical entity. There are numerous case reports describing these injuries, yet few describe those resulting in cerebrovascular injury. Laceration of cerebral blood vessels ma…
View article: Computed tomography-occult discoligamentous instability following blunt cervical spine trauma
Computed tomography-occult discoligamentous instability following blunt cervical spine trauma Open
Plain CT is routinely ordered following blunt trauma of the cervical spine, and performs well in the exclusion of significant bony injuries. MRI is reserved for cases of suspected neural or posterior ligamentous compromise, and when other …
View article: Surgical decompression for malignant cerebral oedema after ischaemic stroke
Surgical decompression for malignant cerebral oedema after ischaemic stroke Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness of surgical decompression in patients with malignant oedema after ischaemic stroke with regards to reduction in mortality a…
View article: SMART (Stroke-Like Migraine Attacks After Radiation Therapy) Syndrome: A Case Study with Imaging Supporting the Theory of Vascular Dysfunction
SMART (Stroke-Like Migraine Attacks After Radiation Therapy) Syndrome: A Case Study with Imaging Supporting the Theory of Vascular Dysfunction Open
BACKGROUND SMART (Stroke-like Migraine Attacks after Radiation Therapy) syndrome is an uncommon delayed complication of cerebral radiotherapy. Less than 50 cases have been reported in the literature since it was first described in 1995. On…
View article: Os odontoideum: a rare cause of syncope
Os odontoideum: a rare cause of syncope Open
Syncopal events are a concerning presentation and timely evaluation is warranted. Common aetiologies include cardiac and neurological pathology such as arrhythmias, vertebrobasilar arterial disease and vasovagal syncope. We describe the ca…
View article: Extra-skeletal Ewing sarcoma of the lumbosacral region in an adult pregnant patient: a case report
Extra-skeletal Ewing sarcoma of the lumbosacral region in an adult pregnant patient: a case report Open
Extra-skeletal Ewing sarcoma in pregnancy is rare. There is thus limited scientific evidence to guide clinicians in its complicated management, particularly within the context of early gestation. We therefore share our successful outcome i…
View article: Bilateral Basal Ganglia Haemorrhage Secondary to Carbon Monoxide Poisoning
Bilateral Basal Ganglia Haemorrhage Secondary to Carbon Monoxide Poisoning Open
Background and Importance: Simultaneous bilateral intracerebral haemorrhages (ICH) are exceedingly rare with only a few cases reported in the literature.Identified causes include systemic arterial hypertension, amyloid angiopathy, vasculit…
View article: Intracranial Chondrosarcoma Resected Via an Extended Endoscopic Endonasal Approach
Intracranial Chondrosarcoma Resected Via an Extended Endoscopic Endonasal Approach Open
Intracranial chondrosarcoma is a rare entity with little consensus regarding surgical and adjuvant management options.The treatment approach to a 27 year old female with a clival chondrosarcoma displacing the basilar artery is described.Th…