Ashraf I. Khasawneh
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View article: The Prevalence of H. pylori Among Jordanian Type 2 Diabetic Patients and Its Association with ABO Blood Group
The Prevalence of H. pylori Among Jordanian Type 2 Diabetic Patients and Its Association with ABO Blood Group Open
Background and Objectives: There is no universal agreement with regard to the correlation between Helicobacter pylori (H. pylori) infection, type 2 diabetes mellitus (T2DM), and ABO blood group antigens. The data related to these are limit…
View article: DIFFERENTIAL EXPRESSION OF PROLIFERATION AND SENESCENCE MARKERS IN RECURRENT GLIOBLASTOMA: INSIGHTS FROM MULTI-DATASET ANALYSIS
DIFFERENTIAL EXPRESSION OF PROLIFERATION AND SENESCENCE MARKERS IN RECURRENT GLIOBLASTOMA: INSIGHTS FROM MULTI-DATASET ANALYSIS Open
AIMS This study aimed to elucidate the roles of therapy-induced senescence (TIS), cancer stemness, and immune eva- sion in glioblastoma (GBM) recurrence by analyzing molecular and immune marker dynamics between paired primary and recurrent…
View article: Prevalence of Acute Gastroenteritis Enteropathogens Among Hospitalized Children in Jordan: A Single-Center Study
Prevalence of Acute Gastroenteritis Enteropathogens Among Hospitalized Children in Jordan: A Single-Center Study Open
Background and objectives: Acute gastroenteritis (AGE) remains a significant cause of morbidity in children, particularly in low- and middle-income countries. Viral pathogens, including rotavirus (RoV), norovirus (NoV), and adenovirus (HAd…
View article: Patterns of the Circulation of Influenza in a Targeted Jordanian Subpopulation from November 2021 to April 2023
Patterns of the Circulation of Influenza in a Targeted Jordanian Subpopulation from November 2021 to April 2023 Open
Background: Influenza remains a global health challenge, causing significant morbidity and mortality. This study explores the epidemiology of influenza A (IAV) and B (IBV) during the 2021–2023 winter seasons within a targeted Jordanian sub…
View article: Oncogene-Induced Senescence Transcriptomes Signify Premalignant Colorectal Adenomas
Oncogene-Induced Senescence Transcriptomes Signify Premalignant Colorectal Adenomas Open
Background: Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism that halts uncontrolled cell proliferation in premalignant lesions. Further investigation into its role in colorectal tumorigenesis is essential. We investigate…
View article: Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue
Resolution of oncogene-induced senescence markers in HPV-infected cervical cancer tissue Open
View article: Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission
Assessment of upper respiratory and gut bacterial microbiomes during COVID-19 infection in adults: potential aerodigestive transmission Open
View article: Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer
Dissociation between the expression of cGAS/STING and a senescence-associated signature in colon cancer Open
Objective: The effect of the cGAS/STING pathway on antitumor immunity and its connection to senescence in vivo necessitates further investigation. Introduction: Cellular senescence and its secretory phenotype (the SASP) are implicated in m…
View article: Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review
Triple Viral Infections in Advanced Breast Cancer: Insights from a Three-Case Report and Literature Review Open
Background and clinical significance: Viral infections are typically considered contributing or secondary factors in the development of breast cancer. Case presentation: This case report presents three instances of advanced breast cancer a…
View article: Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue
Variable Expression of Oncogene-Induced Senescence/SASP Surrogates in HPV-Associated Precancerous Cervical Tissue Open
Oncogene-induced senescence (OIS) is a form of cellular senescence triggered by oncogenic signaling and, potentially, by infection with oncogenic viruses. The role of senescence, along with its associated secretory phenotype, in the develo…
View article: Molecular characterization of human respiratory syncytial virus strains circulating among hospitalized children in Jordan
Molecular characterization of human respiratory syncytial virus strains circulating among hospitalized children in Jordan Open
View article: Enhanced Efficacy of Some Antibiotics in the Presence of Silver Nanoparticles Against Clinical Isolate of Pseudomonas aeruginosa Recovered from Cystic Fibrosis Patients
Enhanced Efficacy of Some Antibiotics in the Presence of Silver Nanoparticles Against Clinical Isolate of Pseudomonas aeruginosa Recovered from Cystic Fibrosis Patients Open
The findings revealed that combining Ag-NPs with antibiotics was more effective than using Ag-NPs or antibiotics in isolation and that combinations of Ag-NPs and antimicrobial agents displayed synergistic activity against the majority of s…
View article: Self-Reported Gastrointestinal Symptoms Associated with NSAIDs and Caffeine Consumption in a Jordanian Subpopulation
Self-Reported Gastrointestinal Symptoms Associated with NSAIDs and Caffeine Consumption in a Jordanian Subpopulation Open
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) and caffeine-containing beverages are widely consumed but their impact on gastrointestinal (GI) health requires further investigation. This cross-sectional study investigated the re…
View article: Are Mouse Mammary Tumor Virus and Bovine Leukemia Virus Linked to Breast Cancer among Jordanian Women?
Are Mouse Mammary Tumor Virus and Bovine Leukemia Virus Linked to Breast Cancer among Jordanian Women? Open
The investigation into the potential association between retroviruses and breast cancer (BC) presents a fascinating area of research. In this study, the focus was on assessing the presence of two retroviruses, Mouse Mammary Tumor Virus (MM…
View article: Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women
Association of Human Papilloma Virus, Cytomegalovirus, and Epstein–Barr Virus with Breast Cancer in Jordanian Women Open
Background and Objectives: The investigation of oncogenic viruses and their potential association with breast cancer (BC) remains an intriguing area of study. The current work aims to assess evidence of three specific viruses, human papill…
View article: Antibiotic resistance of Escherichia coli in Jordan
Antibiotic resistance of Escherichia coli in Jordan Open
Background: Escherichia coli ( E. coli ) is among the most common causes of infections worldwide. Antibiotic resistance accounts for over 50% of E. coli infections, which is mediated by extended spectrum β-lactamases (ESBLs), AmpC β-lactam…
View article: A prospective study of extraesophageal reflux and potential microaspiration in patients hospitalized with COVID-19 in Jordan
A prospective study of extraesophageal reflux and potential microaspiration in patients hospitalized with COVID-19 in Jordan Open
View article: The efficacy of biosynthesized silver nanoparticles against Pseudomonas aeruginosa isolates from cystic fibrosis patients
The efficacy of biosynthesized silver nanoparticles against Pseudomonas aeruginosa isolates from cystic fibrosis patients Open
View article: Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022
Prevalence of SARS-COV-2 and other respiratory pathogens among a Jordanian subpopulation during Delta-to-Omicron transition: Winter 2021/2022 Open
Acute respiratory tract infections (ARTIs) during the winter months are associated with higher morbidity and mortality compared to other seasons of the year, with children below five, elderly, and immunocompromised patients being the most …
View article: Antimicrobial Resistance Molecular Mechanisms of Helicobacter pylori in Jordanian Children: A Cross-Sectional Observational Study
Antimicrobial Resistance Molecular Mechanisms of Helicobacter pylori in Jordanian Children: A Cross-Sectional Observational Study Open
Background: H. pylori antimicrobial resistance causes increasing treatment failure rates among H. pylori gastritis in children. This study investigates the molecular mechanisms of H. pylori antimicrobial resistance among Jordanian children…
View article: Immunoglobulins response of COVID-19 patients, COVID-19 vaccine recipients, and random individuals
Immunoglobulins response of COVID-19 patients, COVID-19 vaccine recipients, and random individuals Open
Background The development of specific immunoglobulins to COVID-19 after natural infection or vaccination has been proposed. The efficacy and dynamics of this response are not clear yet. Aim This study aims to analyze the immunoglobulins r…
View article: Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells
Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells Open
Senescence represents a unique cellular stress response characterized by a stable growth arrest, macromolecular alterations, and wide spectrum changes in gene expression. Classically, senescence is the end-product of progressive telomeric …
View article: Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli
Cefixime and cefixime-clavulanate for screening and confirmation of extended-spectrum beta-lactamases in Escherichia coli Open
View article: Multidrug-Resistant Acinetobacter baumannii in Jordan
Multidrug-Resistant Acinetobacter baumannii in Jordan Open
Background: Acinetobacter baumannii is a common cause of multi-drug (MDR)-resistant infections worldwide. The epidemiological and molecular characteristics of MDR-A. baumannii in Jordan is not known. Methods: A. baumannii isolates were col…
View article: An Analytical Study of the Early COVID-19 Cases in Jordan
An Analytical Study of the Early COVID-19 Cases in Jordan Open
Background: The daily cases and fatalities in the COVID-19 pandemic are still on the rise. This study aimed to examine the epidemiological trends of the COVID-19 patients at an early stage in the pandemic. Methods: This study included all …
View article: COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students
COVID-19-Associated Mental Health Impact on Menstrual Function Aspects: Dysmenorrhea and Premenstrual Syndrome, and Genitourinary Tract Health: A Cross Sectional Study among Jordanian Medical Students Open
The physiology of reproduction is affected by psychological distress through neuroendocrine pathways. Historically, COVID-19 is one of the most stressful events with devastating consequences. This research aims to investigate the relations…
View article: Could “trained immunity” be induced by live attenuated vaccines protect against COVID-19? Review of available evidence
Could “trained immunity” be induced by live attenuated vaccines protect against COVID-19? Review of available evidence Open
Coronavirus disease 2019 (COVID-19) represents a severe global public health threat. Caused by SARS-Cov-2, COVID-19 is characterized by high transmission rate that correlates with high viral load. The full clinical spectrum of the illness,…
View article: Status of Biofilm-Forming Genes among Jordanian Nasal Carriers of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus
Status of Biofilm-Forming Genes among Jordanian Nasal Carriers of Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus Open
In both groups, MRSA isolates, in comparison to MSSA, were significantly more resistant to cefoxitin, oxacillin, imipenem, tetracycline, clindamycin, and trimethoprim-sulfamethoxazole. Unexpectedly, biofilm formation and gene prevalence be…
View article: Medical Students and COVID-19: Knowledge, Attitudes, and Precautionary Measures. A Descriptive Study From Jordan
Medical Students and COVID-19: Knowledge, Attitudes, and Precautionary Measures. A Descriptive Study From Jordan Open
The recent coronavirus disease (COVID-19) pandemic is associated with increasing morbidity and mortality and has impacted the lives of the global populations. Human behavior and knowledge assessment during the crisis are critical in the ov…
View article: Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients
Prevalence of Human Papillomavirus Associated with Head and Neck Squamous Cell Carcinoma in Jordanian Patients Open
Background: In addition to smoking and alcohol consumption, human papillomavirus (HPV) is a leading etiology for Head and Neck Squamous Cell Carcinoma (HNSCC). However, this causal association is still understudied in Middle Eastern popula…