Ashrafali Mohamed Ismail
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View article: Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis
Virus and cell specific HMGB1 secretion and subepithelial infiltrate formation in adenovirus keratitis Open
A highly contagious infection caused by human adenovirus species D (HAdV-D), epidemic keratoconjunctivitis (EKC) results in corneal subepithelial infiltration (SEI) by leukocytes, the hallmark of the infection. To date, the pathogenesis of…
View article: OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus
OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human Adenovirus Open
Genomes of viruses are constrained by the virions’ nanoscale, and viral nucleotide sequences without function are a luxury. Yet the double-stranded DNA genome of human adenovirus (HAdV) contains large regions without known purpose. Using T…
View article: Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis
Virus and Cell Specific HMGB1 Secretion and Subepithelial Infiltrate Formation in Adenovirus Keratitis Open
A highly contagious infection caused by human adenovirus species D (HAdV-D), epidemic keratoconjunctivitis (EKC) results in corneal subepithelial infiltration (SEI) by leukocytes, the hallmark of the infection. To date, the pathogenesis of…
View article: Prophylactic Prednisolone Promotes AAV5 Hepatocyte Transduction Through the Novel Mechanism of AAV5 Coreceptor Platelet-Derived Growth Factor Receptor Alpha Upregulation and Innate Immune Suppression
Prophylactic Prednisolone Promotes AAV5 Hepatocyte Transduction Through the Novel Mechanism of AAV5 Coreceptor Platelet-Derived Growth Factor Receptor Alpha Upregulation and Innate Immune Suppression Open
Adeno-associated virus (AAV) vectors are used to deliver therapeutic transgenes, but host immune responses may interfere with transduction and transgene expression. We evaluated prophylactic corticosteroid treatment on AAV5-mediated expres…
View article: RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa
RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa Open
As intracellular parasites, viruses exploit cellular proteins at every stage of infection. Adenovirus outbreaks are associated with severe acute respiratory illnesses and conjunctivitis, with no specific antiviral therapy available. An ade…
View article: Adenovirus and the Cornea: More Than Meets the Eye
Adenovirus and the Cornea: More Than Meets the Eye Open
Human adenoviruses cause disease at multiple mucosal sites, including the respiratory, gastrointestinal, and genitourinary tracts, and are common agents of conjunctivitis. One site of infection that has received sparse attention is the cor…
View article: Genomics‐based re‐examination of the taxonomy and phylogeny of <i>human</i> and <i>simian Mastadenoviruses</i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis
Genomics‐based re‐examination of the taxonomy and phylogeny of <i>human</i> and <i>simian Mastadenoviruses</i>: an evolving whole genomes approach, revealing putative zoonosis, anthroponosis, and amphizoonosis Open
With the advent of high‐resolution and cost‐effective genomics and bioinformatics tools and methods contributing to a large database of both human (HAdV) and simian (SAdV) adenoviruses, a genomics‐based re‐evaluation of their taxonomy is w…
View article: Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D
Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D Open
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self‐limited, specific viruses within human adenovirus species D …
View article: Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface Open
Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection. Long term …
View article: A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts
A Zoonotic Adenoviral Human Pathogen Emerged through Genomic Recombination among Human and Nonhuman Simian Hosts Open
An emergent adenoviral human pathogen, HAdV-B76, associated with a fatality in 1965, shows a remarkable degree of genome identity with two recently isolated simian adenoviruses that contain cross-species genome recombination events from th…
View article: Divergent Evolution of E1A CR3 in Human Adenovirus Species D
Divergent Evolution of E1A CR3 in Human Adenovirus Species D Open
Adenovirus E1A is the first viral protein expressed during infection. E1A controls critical aspects of downstream viral gene expression and cell cycle deregulation, and its function is thought to be highly conserved among adenoviruses. Var…
View article: Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome
Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome Open
[This corrects the article DOI: 10.3389/fmicb.2018.02178.].
View article: Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
Author Correction: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens Open
The original publication of this article [1] was missing the below author that made contributions to the research and the published article.
View article: Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly
Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly Open
In 1955, Human adenovirus type 14 (HAdV-B14p) was firstly identified in a military trainee diagnosed as acute respiratory disease (ARD) in the Netherlands. Fifty years later, a genomic variant, HAdV-B14p1, re-emerged in the U.S. and caused…
View article: Adenoviromics: Mining the Human Adenovirus Species D Genome
Adenoviromics: Mining the Human Adenovirus Species D Genome Open
Human adenovirus (HAdV) infections cause disease world-wide. Whole genome sequencing has now distinguished 90 distinct genotypes in 7 species (A-G). Over half of these 90 HAdVs fall within species D, with essentially all of the HAdV-D whol…
View article: Bacterial RecA Protein Promotes Adenoviral Recombination during <i>In Vitro</i> Infection
Bacterial RecA Protein Promotes Adenoviral Recombination during <i>In Vitro</i> Infection Open
Adenoviruses are common human mucosal pathogens of the gastrointestinal, respiratory, and genitourinary tracts and ocular surface. Here, we report finding Chi-like sequences in adenovirus recombination hot spots. Adenovirus coinfection in …
View article: Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens
Genomic analysis of a large set of currently—and historically—important human adenovirus pathogens Open
Human adenoviruses (HAdVs) are uniquely important "model organisms" as they have been used to elucidate fundamental biological processes, are recognized as complex pathogens, and are used as remedies for human health. As pathogens, HAdVs m…
View article: Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis
Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis Open
Human adenoviruses (HAdVs) contain seven species (HAdV-A to -G), each associated with specific disease conditions. Among these, HAdV-D includes those viruses associated with epidemic keratoconjunctivitis (EKC), a severe ocular surface infe…
View article: Characterization of hepatitis B virus surface antigen variability and impact on <scp>HB</scp>s antigen clearance under nucleos(t)ide analogue therapy
Characterization of hepatitis B virus surface antigen variability and impact on <span>HB</span>s antigen clearance under nucleos(t)ide analogue therapy Open
Summary For hepatitis B virus ( HBV )‐related chronic infection under treatment by nucleos(t)ide analogues ( NUC s), HB sAg clearance is the ultimate therapeutic goal but very infrequent. We investigated how HBV envelope protein variabilit…