Ashti M. Shah
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View article: Effect of Private Equity Ownership on Access to Outpatient Urologic Cancer Care in Medicare Recipients
Effect of Private Equity Ownership on Access to Outpatient Urologic Cancer Care in Medicare Recipients Open
Overall, there were no large-scale differences in access to outpatient urologic care between PE-owned clinics and non-PE-owned clinics. Access to care in PE-owned clinics is likely clinically similar to geographic-matched controls for Medi…
View article: Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation
Computational inference of chemokine-mediated roles for the vagus nerve in modulating intra- and inter-tissue inflammation Open
Introduction: The vagus nerve innervates multiple organs, but its role in regulating cross-tissue spread of inflammation is as yet unclear. We hypothesized that the vagus nerve may regulate cross-tissue inflammation via modulation of the p…
View article: Changes in self-confidence in professional, personal, and scientific skills by gender during physician-scientist training at the University of Pittsburgh
Changes in self-confidence in professional, personal, and scientific skills by gender during physician-scientist training at the University of Pittsburgh Open
Introduction: Persistence in physician-scientist careers has been suboptimal, particularly among women. There is a gender gap in self-confidence in medicine. We measured the impact of our physician-scientist training programs on trainee’s …
View article: Defining spatiotemporal gene modules in liver regeneration using Analytical Dynamic Visual Spatial Omics Representation (ADViSOR)
Defining spatiotemporal gene modules in liver regeneration using Analytical Dynamic Visual Spatial Omics Representation (ADViSOR) Open
Background: The liver is the only organ with the ability to regenerate following surgical or toxicant insults, and partial hepatectomy serves as an experimental model of liver regeneration (LR). Dynamic changes in gene expression occur fro…
View article: A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes
A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes Open
View article: What’s next for computational systems biology?
What’s next for computational systems biology? Open
Largely unknown just a few decades ago, computational systems biology is now a central methodology for biological and medical research. This amazing ascent raises the question of what the community should do next. The article outlines our …
View article: Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype
Temporally complex inflammatory networks in an animal model reveal signatures for interstitial cystitis and bladder pain syndrome phenotype Open
Introduction and Objective Interstitial cystitis and bladder pain syndrome (IC/BPS) presents with symptoms of debilitating bladder pain and is typically a diagnosis of exclusion. The cystoscopic detection of Hunner's lesions increases the …
View article: Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation
Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation Open
Introduction Vascularized composite allotransplantation (VCA), with nerve repair/coaptation (NR) and tacrolimus (TAC) immunosuppressive therapy, is used to repair devastating traumatic injuries but is often complicated by inflammation span…
View article: Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties
Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties Open
Dynamic Network Analysis (DyNA) and Dynamic Hypergraphs (DyHyp) were used to define protein-level inflammatory networks at the local (wound effluent) and systemic circulation (serum) levels from 140 active-duty, injured service members (59…
View article: Interleukin‐17 as a spatiotemporal bridge from acute to chronic inflammation: Novel insights from computational modeling
Interleukin‐17 as a spatiotemporal bridge from acute to chronic inflammation: Novel insights from computational modeling Open
A systematic review of several acute inflammatory diseases ranging from sepsis and trauma/hemorrhagic shock to the relevant pathology of the decade, COVID‐19, points to the cytokine interleukin (IL)‐17A as being centrally involved in the p…
View article: Large Variations in the Prices of Urologic Procedures at Academic Medical Centers 1 Year After Implementation of the Price Transparency Final Rule
Large Variations in the Prices of Urologic Procedures at Academic Medical Centers 1 Year After Implementation of the Price Transparency Final Rule Open
Importance Patients with urologic diseases often experience financial toxicity, defined as high levels of financial burden and concern, after receiving care. The Price Transparency Final Rule, which requires hospitals to disclose both the …
View article: Promoting female physician-scientists: Perspectives from a unique learning environment
Promoting female physician-scientists: Perspectives from a unique learning environment Open
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View article: A Common Single Nucleotide Polymorphism is Associated with Inflammation and Critical Illness Outcomes
A Common Single Nucleotide Polymorphism is Associated with Inflammation and Critical Illness Outcomes Open
View article: Temporally Complex Inflammatory Networks in an Animal Model Reveal Signatures for Interstitial Cystitis and Bladder Pain Syndrome Phenotype
Temporally Complex Inflammatory Networks in an Animal Model Reveal Signatures for Interstitial Cystitis and Bladder Pain Syndrome Phenotype Open
Introduction and Objective Interstitial cystitis and bladder pain syndrome (IC/BPS) presents with symptoms of debilitating bladder pain and is typically a diagnosis of exclusion. Patients with Hunner’s lesions and tissue inflammation on bl…
View article: Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling
Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling Open
Trauma/hemorrhagic shock followed by resuscitation (T/HS-R) results in multi-system inflammation and organ dysfunction, in part driven by binding of damage-associated molecular pattern molecules to Toll-like Receptor 4 (TLR4). We carried o…
View article: Neural asymmetry during memory encoding and its association with markers of preclinical Alzheimer’s Disease
Neural asymmetry during memory encoding and its association with markers of preclinical Alzheimer’s Disease Open
Background Alzheimer’s Disease (AD) is the most common form of dementia and is characterized by cognitive dysfunction that impacts daily functioning. Beta-amyloid (Aβ) is a cytotoxic protein that deposits in the brain many years prior to t…
View article: Fixed and flexible: Dynamic prefrontal activations and working memory capacity relationships vary with memory demand
Fixed and flexible: Dynamic prefrontal activations and working memory capacity relationships vary with memory demand Open
Prefrontal cortex (PFC) activation during encoding of memoranda (proactive responses) is associated with better working memory (WM) compared to reactive/retrieval-based activation. This suggests that dynamic PFC activation patterns may be …