Aparna Wagle Shukla
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View article: Segmental and Multifocal Isolated Dystonias: Similarities and Differences
Segmental and Multifocal Isolated Dystonias: Similarities and Differences Open
Background Whether the traditional distinction between segmental and multifocal dystonia is clinically or scientifically useful remains unclear. Objective To evaluate whether idiopathic isolated adult‐onset segmental and multifocal dystoni…
View article: Advancements in invasive and non-invasive neuromodulation for Parkinson’s disease: current findings and future directions
Advancements in invasive and non-invasive neuromodulation for Parkinson’s disease: current findings and future directions Open
View article: Patient, target, device, and program selection for DBS in Parkinson’s disease: advancing toward precision care
Patient, target, device, and program selection for DBS in Parkinson’s disease: advancing toward precision care Open
View article: Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing
Genetic Diversity and Expanded Phenotypes in Dystonia: Insights From Large‐Scale Exome Sequencing Open
Objective Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, und…
View article: Impact of Demographic Variables on Behavioural Biases and Stock Market Investment Decisions
Impact of Demographic Variables on Behavioural Biases and Stock Market Investment Decisions Open
The rationality hypothesis has been a very popular topic among the academics. Being a widely accepted hypothesis as part of the traditional finance theories, an investor is deemed a rational agent and makes rational decisions by exhausting…
View article: Effect of self-myofascial release on latent myofascial trigger points in physically active male individuals
Effect of self-myofascial release on latent myofascial trigger points in physically active male individuals Open
Self-massage techniques using foam rollers and massage sticks have gained popularity for enhancing athletic performance and recovery. This study evaluated the effectiveness of self-myofascial release (SMR) on latent myofascial trigger poin…
View article: Non-invasive brain stimulation to modulate neural activity in Parkinson’s disease
Non-invasive brain stimulation to modulate neural activity in Parkinson’s disease Open
View article: Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing
Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing Open
Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (∼25%) and the identification of several disease-linked genes, the etiology in…
View article: Clinical and physiological characteristics of tremor in a large cohort of focal and segmental dystonia
Clinical and physiological characteristics of tremor in a large cohort of focal and segmental dystonia Open
Objective Tremor is a frequent co-occurring feature in patients with dystonia, especially in focal and segmental dystonia. Clinical studies have shown that tremor is more commonly observed when dystonia spreads to contiguous body regions. …
View article: Sex Differences in Dystonia
Sex Differences in Dystonia Open
Background Prior studies have indicated that female individuals outnumber male individuals for certain types of dystonia. Few studies have addressed factors impacting these sex differences or their potential biological mechanisms. Objectiv…
View article: Validation of a New Patient-Reported Outcome Measure of the Functional Impact of Essential Tremor on Activities of Daily Living
Validation of a New Patient-Reported Outcome Measure of the Functional Impact of Essential Tremor on Activities of Daily Living Open
Background: The Essential Tremor Rating Assessment Scale (TETRAS) is a popular scale for essential tremor (ET), but its activities of daily living (ADL) and performance (P) subscales are based on a structured interview and physical exam. N…
View article: Tremor in cervical dystonia
Tremor in cervical dystonia Open
Background: Cervical dystonia (CD) is the most common form of focal dystonia encountered in the clinic. Approximately one-third of CD patients have co-existing tremor in the head and hands. Assessment of tremor as regular or irregular in c…
View article: The Vocal Flutter of Multiple System Atrophy: A <scp>Parkinsonian‐Type</scp> Phenomenon?
The Vocal Flutter of Multiple System Atrophy: A <span>Parkinsonian‐Type</span> Phenomenon? Open
Background Early features of multiple system atrophy (MSA) are similar to those in Parkinson's disease (PD), which can challenge differential diagnosis. Identifying clinical markers that help distinguish MSA from forms of parkinsonism is e…
View article: Case report: Lingual dystonia symptoms treated with botulinum toxin in patients with THAP1 mutation
Case report: Lingual dystonia symptoms treated with botulinum toxin in patients with THAP1 mutation Open
Background: THAP1 mutation dystonia is a known genetic cause of generalized dystonia. THAP1 mutation frequently presents with clinical features of bulbar dysfunction, including oromandibular and lingual dystonia. Patients complain of signi…
View article: Roussy-Lévy Syndrome: Pes Cavus, Tendon Areflexia, Amyotrophy, Gait Ataxia, and Upper Limb Tremor in a Patient with CMT Neuropathy
Roussy-Lévy Syndrome: Pes Cavus, Tendon Areflexia, Amyotrophy, Gait Ataxia, and Upper Limb Tremor in a Patient with CMT Neuropathy Open
This video abstract depicts a bilateral hand tremor characteristic of Roussy-Lévy syndrome seen in patients with Charcot-Marie-Tooth disease neuropathy. The significance of the abstract lies in the phenomenology and the physiology of the t…
View article: Rhythmic Jaw Movements in Amyotrophic Lateral Sclerosis: Is It Clonus or Tremor?
Rhythmic Jaw Movements in Amyotrophic Lateral Sclerosis: Is It Clonus or Tremor? Open
The presented video abstract shows a patient with amyotrophic lateral sclerosis with rhythmic jaw movements seen at rest. A power spectrum analysis of the rhythmic movements revealed a 10 Hz peak, a frequency higher than those seen in pati…
View article: Some Useful Plants in Treatment of Ganga Water Pollution and Human Healthcare in India
Some Useful Plants in Treatment of Ganga Water Pollution and Human Healthcare in India Open
Long distance of 2510 km long river basin, originating from Bhagirathi from Gangotri glacier in Uttarakhand, The Ganga is the most sacred river of India which is symbolic of purity and moksha and plays a crucial role in the growth of India…
View article: An Empirical Comparison of Commonly Used Universal Rating Scales for Dystonia
An Empirical Comparison of Commonly Used Universal Rating Scales for Dystonia Open
Background There are several widely used clinical rating scales for documenting the severity and distribution of various types of dystonia. Objectives The goal of this study was to evaluate the performance of the most commonly used scales …
View article: Non-motor symptoms in dystonia: from diagnosis to treatment
Non-motor symptoms in dystonia: from diagnosis to treatment Open
The Dystonia Medical Research Foundation organized an expert virtual workshop in March 2023 to review the evidence on non-motor symptoms across the spectrum of dystonia, discuss existing assessment methods, need for their harmonisation and…
View article: Longitudinal predictors of health-related quality of life in isolated dystonia
Longitudinal predictors of health-related quality of life in isolated dystonia Open
Objective To determine longitudinal predictors of health-related quality of life (HR-QoL) in an international multicenter cohort of patients with isolated dystonia. Methods Out of 603 dystonia patients prospectively enrolled in the Natural…
View article: Clinical Pearls in Anaesthesia and Critical Care: A Handbook for Technicians
Clinical Pearls in Anaesthesia and Critical Care: A Handbook for Technicians Open
The Uttar Pradesh State Medical Faculty has recently unveiled a new paramedical program called the "Diploma in Anaesthesia and Critical Care Technician." This is in response to the shortage of skilled anaesthesia technicians in government …
View article: Tremor Induced by Cyclosporine, Tacrolimus, Sirolimus, or Everolimus: A Review of the Literature
Tremor Induced by Cyclosporine, Tacrolimus, Sirolimus, or Everolimus: A Review of the Literature Open
Calcineurin inhibitors such as cyclosporine and tacrolimus are immunosuppressant drugs that are known to induce tremors. Non-calcineurin inhibitors such as sirolimus and everolimus have also reportedly been accompanied by tremors, albeit l…
View article: Gait and balance in cervical dystonia and dystonic head tremor
Gait and balance in cervical dystonia and dystonic head tremor Open
Background: Previous studies have found gait and balance abnormalities in patients with cervical dystonia. However, the characteristics of gait and balance in cervical dystonia with head tremors have not been ascertained. A midline constan…
View article: Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process
Pain control due to botulinum toxin therapy in cervical dystonia relates to the sensorimotor integration process Open
Background: Botulinum toxin (BoNT) injections have been found to improve pain symptoms of isolated cervical dystonia (CD). In addition to muscle relaxation at the peripheral level, few studies suggest that BoNT has effects on the central b…
View article: Anatomical categorization of isolated non-focal dystonia: novel and existing patterns using a data-driven approach
Anatomical categorization of isolated non-focal dystonia: novel and existing patterns using a data-driven approach Open
According to expert consensus, dystonia can be classified as focal, segmental, multifocal, and generalized, based on the affected body distribution. To provide an empirical and data-driven approach to categorizing these distributions, we u…
View article: Hematoma-induced Twiddler-like phenomenon as a presentation of DBS hardware failure: Case report
Hematoma-induced Twiddler-like phenomenon as a presentation of DBS hardware failure: Case report Open
Deep brain stimulators (DBS) may fail for a multitude of reasons. We present a 79-year-old Parkinson's disease patient who suffered a DBS failure following impulse generator (IPG) replacement surgery due to the IPG flipping within an expan…
View article: Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease
Globus pallidus internus deep brain stimulation evokes resonant neural activity in Parkinson’s disease Open
Globus pallidus internus deep brain stimulation is an established therapy for patients with medication-refractory Parkinson’s disease. Clinical outcomes are highly dependent on applying stimulation to precise locations in the brain. Howeve…
View article: Sex Differences in Dystonia
Sex Differences in Dystonia Open
View article: Phenomenology and Physiology of Tacrolimus Induced Tremor
Phenomenology and Physiology of Tacrolimus Induced Tremor Open
Limb cooling may be pursued as a therapeutic option for addressing tacrolimus-induced tremor, as the patients in our cohort benefitted from temporary tremor suppression.
View article: Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review
Clinical Features and Evolution of Blepharospasm: A Multicenter International Cohort and Systematic Literature Review Open
Objective: Blepharospasm is a type of dystonia where the diagnosis is often delayed because its varied clinical manifestations are not well recognized. The purpose of this study was to provide a comprehensive picture of its clinical featur…