Ashutosh Vashisht
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View article: Analytical Evaluation of Whole Genome Sequencing for Acute Myeloid Leukemia
Analytical Evaluation of Whole Genome Sequencing for Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is the most common leukemia in adults and current methods rely on cytogenic and molecular profiling for AML classification and risk stratification. Recent advances have demonstrated that next generation sequenc…
View article: Referee report. For: Knowledge, attitudes, and practices regarding male infertility: A cross-sectional study among infertile couples visiting fertility clinics in Indonesia’s urban areas [version 2; peer review: 1 approved, 1 approved with reservations]
Referee report. For: Knowledge, attitudes, and practices regarding male infertility: A cross-sectional study among infertile couples visiting fertility clinics in Indonesia’s urban areas [version 2; peer review: 1 approved, 1 approved with reservations] Open
View article: Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer
Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer Open
We developed a 3-gene signature with the potential for prognostic and predictive clinical assessment of CRC patients. This gene-based stratification offers a cost-effective approach to personalized cancer management. Further research using…
View article: From Genomic Exploration to Personalized Treatment: Next-Generation Sequencing in Oncology
From Genomic Exploration to Personalized Treatment: Next-Generation Sequencing in Oncology Open
Next-generation sequencing (NGS) has revolutionized personalized oncology care by providing exceptional insights into the complex genomic landscape. NGS offers comprehensive cancer profiling, which enables clinicians and researchers to bet…
View article: Enhancing Precision in HIV Treatment: Validation of a Robust Next-Generation Sequencing System for Drug Resistance Mutation Analysis
Enhancing Precision in HIV Treatment: Validation of a Robust Next-Generation Sequencing System for Drug Resistance Mutation Analysis Open
Background: Multidrug-resistant HIV strains challenge treatment efficacy and increase mortality rates. Next-generation sequencing (NGS) technology swiftly detects variants, facilitating personalized antiretroviral therapy. Aim: This study …
View article: Clinical Utility of Optical Genome Mapping for Improved Cytogenomic Analysis of Gliomas
Clinical Utility of Optical Genome Mapping for Improved Cytogenomic Analysis of Gliomas Open
A glioma is a solid brain tumor which originates in the brain or brain stem area. The diagnosis of gliomas based on standard-of-care (SOC) techniques includes karyotyping, fluorescence in situ hybridization (FISH), and chromosomal microarr…
View article: Gene Regulatory Network Analysis of Post-Mortem Lungs Unveils Novel Insights into COVID-19 Pathogenesis
Gene Regulatory Network Analysis of Post-Mortem Lungs Unveils Novel Insights into COVID-19 Pathogenesis Open
The novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as one of the most significant global health crises in recent history. The clinical characteristics of C…
View article: Genomics for Emerging Pathogen Identification and Monitoring: Prospects and Obstacles
Genomics for Emerging Pathogen Identification and Monitoring: Prospects and Obstacles Open
Emerging infectious diseases (EIDs) pose an increasingly significant global burden, driven by urbanization, population explosion, global travel, changes in human behavior, and inadequate public health systems. The recent SARS-CoV-2 pandemi…
View article: Understanding seminal plasma in male infertility: emerging markers and their implications
Understanding seminal plasma in male infertility: emerging markers and their implications Open
Infertility affects a significant proportion of the reproductive‐aged population, with male‐associated factors contributing to over half of the cases. However, current diagnostic tools have limitations, leading to an underestimation of the…
View article: Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers
Ethno‐demographic disparities in humoral responses to the COVID‐19 vaccine among healthcare workers Open
The COVID‐19 pandemic had a profound impact on global health, but rapid vaccine administration resulted in a significant decline in morbidity and mortality rates worldwide. In this study, we sought to explore the temporal changes in the hu…
View article: Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation
Optical Genome Mapping: Integrating Structural Variations for Precise Homologous Recombination Deficiency Score Calculation Open
Homologous recombination deficiency (HRD) is characterized by the inability of a cell to repair the double-stranded breaks using the homologous recombination repair (HRR) pathway. The deficiency of the HRR pathway results in defective DNA …
View article: Immune Factors Drive Expression of SARS-CoV-2 Receptor Genes Amid Sexual Disparity
Immune Factors Drive Expression of SARS-CoV-2 Receptor Genes Amid Sexual Disparity Open
The emergence of COVID-19 has led to significant morbidity and mortality, with around seven million deaths worldwide as of February 2023. There are several risk factors such as age and sex that are associated with the development of severe…
View article: Poster: CML-384 Immunological Response to SARS-CoV-2 After Infection and/or Vaccination Among Chronic Myeloid Leukemia Patients – A Prospective Study
Poster: CML-384 Immunological Response to SARS-CoV-2 After Infection and/or Vaccination Among Chronic Myeloid Leukemia Patients – A Prospective Study Open
View article: CML-384 Immunological Response to SARS-CoV-2 After Infection and/or Vaccination Among Chronic Myeloid Leukemia Patients – A Prospective Study
CML-384 Immunological Response to SARS-CoV-2 After Infection and/or Vaccination Among Chronic Myeloid Leukemia Patients – A Prospective Study Open
View article: A Comparative Analysis of the Altered Levels of Human Seminal Plasma Constituents as Contributing Factors in Different Types of Male Infertility
A Comparative Analysis of the Altered Levels of Human Seminal Plasma Constituents as Contributing Factors in Different Types of Male Infertility Open
(1) Background: The relationships between the biochemical and immunological components in seminal plasma and their physiological effects on male reproductive system have been underreported. In this study, we evaluated the potential of seve…
View article: Electrochemical treatment of high strength chrome bathwater: A comparative study for best-operating conditions
Electrochemical treatment of high strength chrome bathwater: A comparative study for best-operating conditions Open
In this study, high strength chromium (1500 ppm) wastewater was treated by electrochemical and chemical precipitation. Preliminary experiments using synthetic wastewater were carried out to optimize the process parameters viz. pH, current…
View article: Using miRNAs as diagnostic biomarkers for male infertility: opportunities and challenges
Using miRNAs as diagnostic biomarkers for male infertility: opportunities and challenges Open
The non-coding genome has been extensively studied for its role in human development and diseases. MicroRNAs (miRNAs) are small non-coding RNAs, which can regulate the expression of hundreds of genes at the post-transcriptional level. Ther…